scholarly journals Calcium Phosphates and Angiogenesis: Implications and Advances for Bone Regeneration

2016 ◽  
Vol 34 (12) ◽  
pp. 983-992 ◽  
Author(s):  
Angad Malhotra ◽  
Pamela Habibovic
Keyword(s):  
Bone Regeneration ◽  
Calcium Phosphates

Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration

2019 ◽  
Vol 17 (1) ◽  
pp. 342-353 ◽  
Author(s):  
Cristina‐Daniela Ghițulică ◽  
Andreia Cucuruz ◽  
Georgeta Voicu ◽  
Andrei T. Cucuruz ◽  
Sorina Dinescu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Calcium Phosphates ◽  
Magnesium Ions

Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration

2020 ◽  
Vol 179 ◽  
pp. 109253
Author(s):  
Vivian Inês dos Santos ◽  
Claudia Merlini ◽  
Águedo Aragones ◽  
Karina Cesca ◽  
Márcio Celso Fredel
Keyword(s):  
Bone Regeneration ◽  
Glycolic Acid ◽  
Calcium Phosphates ◽  
Guided Bone Regeneration ◽  
Electrospun Membranes

scholarly journals Enhancement of Bone Regeneration on Calcium-Phosphate-Coated Magnesium Mesh: Using the Rat Calvarial Model

2021 ◽  
Vol 9 ◽  
Author(s):  
Shuang Wu ◽  
Yong-Seok Jang ◽  
Min-Ho Lee
Keyword(s):  
Bone Regeneration ◽  
Surface Properties ◽  
Critical Size ◽  
Calcium Phosphates ◽  
Cell Seeding ◽  
Critical Size Defect ◽  
Direct Cell ◽  
Cell Affinity ◽  
Biodegradable Magnesium

Metallic biodegradable magnesium (Mg) is a promising material in the biomedical field owing to its excellent biocompatibility, bioabsorbability, and biomechanical characteristics. Calcium phosphates (CaPs) were coated on the surface of pure Mg through a simple alkali-hydrothermal treatment. The surface properties of CaP coatings formed on Mg were identified through wettability, direct cell seeding, and release tests since the surface properties of biomaterials can affect the reaction of the host tissue. The effect of CaP-coated Mg mesh on guided bone regeneration in rat calvaria with the critical-size defect was also evaluated in vivo using several comprehensive analyses in comparison with untreated Mg mesh. Following the application of protective CaP coating, the surface energy of Mg improved with higher hydrophilicity and cell affinity. At the same time, the CaP coating endowed Mg with higher Ca affinity and lower degradation. The Mg mesh with CaP coating had higher osteointegration and bone affinity than pristine Mg mesh.

scholarly journals Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 95 ◽  
Author(s):  
Kaoru Aoki ◽  
Naoto Saito
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Drug Delivery Systems ◽  
Calcium Phosphates ◽  
Delivery Systems ◽  
Polymer Scaffolds ◽  
Synthetic Scaffold ◽  
And Performance ◽  
Potential Use

Regenerative medicine has been widely researched for the treatment of bone defects. In the field of bone regenerative medicine, signaling molecules and the use of scaffolds are of particular importance as drug delivery systems (DDS) or carriers for cell differentiation, and various materials have been explored for their potential use. Although calcium phosphates such as hydroxyapatite and tricalcium phosphate are clinically used as synthetic scaffold material for bone regeneration, biodegradable materials have attracted much attention in recent years for their clinical application as scaffolds due their ability to facilitate rapid localized absorption and replacement with autologous bone. In this review, we introduce the types, features, and performance characteristics of biodegradable polymer scaffolds in their role as DDS for bone regeneration therapy.

Bone Regenerative Property of Octacalcium Phosphate in Mouse Critical Sized Calvarial Defects

2007 ◽  
Vol 361-363 ◽  
pp. 1253-1256
Author(s):  
Yoshitomo Honda ◽  
Shinji Kamakura ◽  
Takashi Kumagai ◽  
Osamu Suzuki
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Calcium Phosphates ◽  
Octacalcium Phosphate ◽  
Regeneration Ability ◽  
Synthesis Methods ◽  
Tartrate Resistant Acid Phosphatase ◽  
Calvarial Bone ◽  
Calvarial Defects ◽  
Wet Synthesis

Bone regeneration by calcium phosphates has been known to be intricately dependent on material properties or implanted milieu of host animals, such as site and species. Critical sized calvarial defects of mouse were recently used as the model for investigating bone regeneration ability and the mechanisms. The purpose of the present study is to investigate whether the critical sized mouse calvarial defects can be utilized to examine bone regeneration with synthetic octacalcium phosphate (OCP). OCP , prepared by wet synthesis methods, was sieved 0.3 ~ 0.5 mm in diameter and used for the animal experiment. At 14 days after surgery, histological examination showed that implantation of OCP grafted defects significantly enhanced bone formation compared with the control defect. OCP tended to convert to hydroxyapatite with time. The tartrate-resistant acid phosphatase (TRAP) positive osteoclastic cells were observed around the OCP particles. The results suggest that the mouse critical sized calvarial bone defects are useful model to investigate the bone formation by the OCP implantation.

The shape-effect of calcium phosphate nanoparticle based films on their osteogenic properties

2021 ◽  
Author(s):  
Pichaporn Sutthavas ◽  
Pamela Habibovic ◽  
Sabine van Rijt
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Mineral ◽  
Calcium Phosphates ◽  
Shape Effect ◽  
Chemical Similarity ◽  
Natural Bone Mineral ◽  
Natural Bone ◽  
Calcium Phosphate Nanoparticle

Calcium phosphates (CaPs) in the form of hydroxyapatite (HA) have been extensively studied in the context of bone regeneration due to their chemical similarity to natural bone mineral. While HA...

An in vitro evaluation of the Ca/P ratio for the cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration

2008 ◽  
Vol 4 (5) ◽  
pp. 1472-1479 ◽  
Author(s):  
Huinan Liu ◽  
Hilal Yazici ◽  
Celaletdin Ergun ◽  
Thomas J. Webster ◽  
Hakan Bermek
Keyword(s):  
Bone Regeneration ◽  
Calcium Phosphates ◽  
In Vitro Evaluation

Magnetic Nanoparticles Inclusion into Scaffolds Based on Calcium Phosphates and Biopolymers for Bone Regeneration

2017 ◽  
Vol 745 ◽  
pp. 16-25 ◽  
Author(s):  
Florina Daniela Ivan ◽  
Vera Balan ◽  
Maria Butnaru ◽  
Ionel Marcel Popa ◽  
Liliana Verestiuc
Keyword(s):  
Magnetic Nanoparticles ◽  
Bone Regeneration ◽  
Human Body ◽  
Calcium Phosphates ◽  
Biological Fluids ◽  
Natural Bone ◽  
Biodegradable Scaffolds ◽  
Co Precipitation

Considering its functions (support, protection, assisting in movement and storage of minerals), the bone is an essential organ for the human body and the bone trauma/damages have a great impact on the human body functionality. For that reason a variety of biomaterials are studied for potential applications in bone regeneration or substitution. Bone substitution materials, with similar chemical composition to that of natural bone, and specifically those obtained by processes which mimic the natural bone formation in vivo, has been shown to be among the best. In this study, using a process of co-precipitation of calcium phosphate precursors on a mixture of biopolymers (chitosan, collagen, hialuronic acid) and magnetic nanoparticles (magnetite functionalized with chitosan), biodegradable biomimetic scaffolds have been obtained. In order to study their chemical structure, the biodegradable scaffolds have been characterized by Fourier Transform Infrared Spectroscopy (FTIR). The morphology of the biodegradable scaffolds, studied using scanning electron microscopy (SEM) indicated a macroporous morphology, which influenced the retention of simulated biological fluids. A direct relationship between the scaffolds’ degradation rate and the concentration of the polymeric phase has been observed. The in vitro cytocompatibility tests indicate that the prepared scaffolds are biocompatible and assure and adequate mediums for osteoblasts.

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