Renal progenitors in non-diabetic and diabetic nephropathies

2013 ◽  
Vol 24 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Paola Romagnani ◽  
Giuseppe Remuzzi
Keyword(s):  
Diabetic Nephropathies ◽  
Renal Progenitors

INDUCTION OF NEPHRONS FROM RENAL PROGENITORS BY MULTIPLE SIGNALS

ASAIO Journal ◽  
2003 ◽  
Vol 49 (2) ◽  
pp. 198
Author(s):  
J Barasch ◽  
J Yang ◽  
K Mori
Keyword(s):  
Multiple Signals ◽  
Renal Progenitors

Evidence for Renal Progenitors in the Human Kidney

2016 ◽  
pp. 395-406
Author(s):  
Laura Lasagni ◽  
Elena Lazzeri ◽  
Anna Peired ◽  
Paola Romagnani
Keyword(s):  
Human Kidney ◽  
Renal Progenitors

scholarly journals Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Barbara Imberti ◽  
Susanna Tomasoni ◽  
Osele Ciampi ◽  
Anna Pezzotta ◽  
Manuela Derosas ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Mouse Model ◽  
Kidney Injury ◽  
Human Ipscs ◽  
Renal Progenitors

scholarly journals Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction

2017 ◽  
Vol 29 (2) ◽  
pp. 532-544 ◽  
Author(s):  
Sepideh Sheybani-Deloui ◽  
Lijun Chi ◽  
Marian V. Staite ◽  
Jason E. Cain ◽  
Brian J. Nieman ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Progenitor Cells ◽  
Hedgehog Signaling ◽  
Ureteropelvic Junction Obstruction ◽  
Lineage Tracing ◽  
Ureteropelvic Junction ◽  
Genetic Lineage ◽  
Intermediate Mesoderm ◽  
Renal Progenitors ◽  
Deficient Mice

Intrinsic ureteropelvic junction obstruction is the most common cause of congenital hydronephrosis, yet the underlying pathogenesis is undefined. Hedgehog proteins control morphogenesis by promoting GLI-dependent transcriptional activation and inhibiting the formation of the GLI3 transcriptional repressor. Hedgehog regulates differentiation and proliferation of ureteric smooth muscle progenitor cells during murine kidney-ureter development. Histopathologic findings of smooth muscle cell hypertrophy and stroma-like cells, consistently observed in obstructing tissue at the time of surgical correction, suggest that Hedgehog signaling is abnormally regulated during the genesis of congenital intrinsic ureteropelvic junction obstruction. Here, we demonstrate that constitutively active Hedgehog signaling in murine intermediate mesoderm–derived renal progenitors results in hydronephrosis and failure to develop a patent pelvic-ureteric junction. Tissue obstructing the ureteropelvic junction was marked as early as E13.5 by an ectopic population of cells expressing Ptch2, a Hedgehog signaling target. Constitutive expression of GLI3 repressor in Ptch1-deficient mice rescued ectopic Ptch2 expression and obstructive hydronephrosis. Whole transcriptome analysis of isolated Ptch2+ cells revealed coexpression of genes characteristic of stromal progenitor cells. Genetic lineage tracing indicated that stromal cells blocking the ureteropelvic junction were derived from intermediate mesoderm–derived renal progenitors and were distinct from the smooth muscle or epithelial lineages. Analysis of obstructive ureteric tissue resected from children with congenital intrinsic ureteropelvic junction obstruction revealed a molecular signature similar to that observed in Ptch1-deficient mice. Together, these results demonstrate a Hedgehog-dependent mechanism underlying mammalian intrinsic ureteropelvic junction obstruction.

scholarly journals 14-P007 Differentiation of human embryonic stem cells towards renal progenitors

2009 ◽  
Vol 126 ◽  
pp. S241 ◽  
Author(s):  
Karamjit Singh Dolt ◽  
David Edgar ◽  
Simon Kenny ◽  
Patricia Murray
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Renal Progenitors

scholarly journals Author response: Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development

2016 ◽  
Author(s):  
Shahram Jevin Poureetezadi ◽  
Christina N Cheng ◽  
Joseph M Chambers ◽  
Bridgette E Drummond ◽  
Rebecca A Wingert
Keyword(s):  
Kidney Development ◽  
Author Response ◽  
Nephron Segment ◽  
Renal Progenitors

scholarly journals Co‐cultures of renal progenitors and endothelial cells on kidney decellularized matrices replicate the renal tubular environment in vitro

2020 ◽  
Vol 230 (1) ◽  
Author(s):  
Rita Sobreiro‐Almeida ◽  
Maria Elena Melica ◽  
Laura Lasagni ◽  
Paola Romagnani ◽  
Nuno M. Neves
Keyword(s):  
Endothelial Cells ◽  
Renal Tubular ◽  
Renal Progenitors
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