Crystallization behaviors of biodegradable poly(l-lactic acid)/graphene oxide nanocomposites from the amorphous state

2011 ◽  
Vol 526 (1-2) ◽  
pp. 229-236 ◽  
Author(s):  
Huishan Wang ◽  
Zhaobin Qiu
2014 ◽  
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George Z. Papageorgiou ◽  
Zoe Terzopoulou ◽  
Dimitrios Bikiaris ◽  
Konstantinos S. Triantafyllidis ◽  
Evmorfia Diamanti ◽  
...  

LWT ◽  
2021 ◽  
pp. 112356
Author(s):  
Phatthranit Klinmalai ◽  
Atcharawan Srisa ◽  
Yeyen Laorenza ◽  
Wattinee Katekhong ◽  
Nathdanai Harnkarnsujarit

2018 ◽  
Vol 381 (1) ◽  
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Elaine C. Lopes Pereira ◽  
Bluma G. Soares ◽  
Rayan B. Jesus ◽  
Alex S. Sirqueira

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
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Dongsheng Gu ◽  
Gaoke Feng ◽  
Guanyang Kang ◽  
Xiaoxin Zheng ◽  
Yuying Bi ◽  
...  

Using poly-L-lactic acid for implantable biodegradable scaffold has potential biocompatibility issue due to its acidic degradation byproducts. We have previously reported that the addition of amorphous calcium phosphate improved poly-L-lactic acid coating biocompatibility. In the present study, poly-L-lactic acid and poly-L-lactic acid/amorphous calcium phosphate scaffolds were implanted in pig coronary arteries for 28 days. At the follow-up angiographic evaluation, no case of stent thrombosis was observed, and the arteries that were stented with the copolymer scaffold had significantly less inflammation and nuclear factor-κB expression and a greater degree of reendothelialization. The serum levels of vascular endothelial growth factor and nitric oxide, as well the expression of endothelial nitric oxide synthase and platelet-endothelial cell adhesion molecule-1, were also significantly higher. In conclusion, the addition of amorphous calcium phosphate to biodegradable poly-L-lactic acid scaffold minimizes the inflammatory response, promotes the growth of endothelial cells, and accelerates the reendothelialization of the stented coronary arteries.


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