Kinetic investigation and predictive model for the isothermal degradation time in two commercial acetylsalicylic acid-based pharmaceutical tablet formulations

2011 ◽  
Vol 526 (1-2) ◽  
pp. 151-156 ◽  
Author(s):  
Luigi Campanella ◽  
Valentina Micieli ◽  
Mauro Tomassetti ◽  
Stefano Vecchio
Keyword(s):  
Acetylsalicylic Acid ◽  
Predictive Model ◽  
Kinetic Investigation ◽  
Pharmaceutical Tablet ◽  
Tablet Formulations ◽  
Degradation Time

Bioavailability study of two 81-mg coated tablet formulations of acetylsalicylic acid in fed healthy subjects

2020 ◽  
Vol 58 (08) ◽  
pp. 457-464
Author(s):  
Raul Cleverson Dolores ◽  
Natalícia de Jesus Antunes ◽  
Alexandre Scremin Czezacki ◽  
Carolina Previato ◽  
Rafael Campos ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Healthy Subjects ◽  
Coated Tablet ◽  
Bioavailability Study ◽  
Tablet Formulations

scholarly journals Analysis on Bulk Pharmaceutical Formulation, Validation and Estimation Using Levetiracetam Methods

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 292-295
Author(s):  
Smitha M ◽  
Kal Satyavathi Devi ◽  
Virendra Kumar ◽  
Jaffar Hussain
Keyword(s):  
Pharmaceutical Formulation ◽  
Standard Result ◽  
Pharmaceutical Tablet ◽  
Rp Hplc ◽  
Hplc System ◽  
Relationship Coefficient ◽  
Tablet Formulations ◽  
Hplc Technique

A new sensitive, specific, direct, exact and correct RP-HPLC technique is established and authenticated to estimate Levetiracetam in Majority and Pharmaceutical Tablet Formulations. An isocratic, turned around period HPLC system might have been created should differentiate the pill starting with the corruption products, Phenomenex Gemini 5µ C18 (2) 100A (250 x 4.60mm, 5 µ) section. Hamilton syringe (705 NR, 50 µL) might have been utilized to injecting example Furthermore standard result. The versatile stage comprises about mixture of Methanol: Acetonitrile in the proportion (90:10 v/v) toward A stream rate about 1.0 ml /min. UV identification might have been performed toward 210 nm. The linearity might have been made for Levetiracetam in the extent from claiming 5- 30µg/ml for relationship coefficient about 0.9997. LOD Also LOQ were found will make 0.076µg/ml Furthermore 0.23µg/ml individually. Maintenance duration of the time of Levetiracetam were found with make 2.281min and 2.274min. % recuperation might have been discovered on be 99.78-100.45 What's more %RSD might have been found for over ±2. Those system needs been approved as stated by ICH rules to linearity, precision, accuracy, robustness, ruggedness, LOD furthermore LOQ. Those produced approved system might have been effectively connected to dependable quantification about Levetiracetam to mass and pharmaceutical measurement type.

Validated UV-Visible spectrometry using water as a solvent for determination of chloroquine in tablet samples

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Linear Dependence ◽  
Dosage Forms ◽  
Distilled Water ◽  
Pharmaceutical Tablet ◽  
Accuracy And Precision ◽  
Tablet Formulations ◽  
Uv Visible ◽  
Tablet Dosage ◽  
Excellent Accuracy

Methods reported including the official methods for determination ofchloroquine in tablet samples use carcinogenic organic solvents. In this study,UV-Vis spectrometry using water as a solvent was developed for determination ofchloroquine phosphate in pharmaceutical tablet dosage forms. The method wasvalidated according to the International Conference on Harmonization (ICH) andUSP guidelines. The absorbance of chloroquine phosphate in distilled water at max of 343 nm showed linear dependence on concentration in the range 10.88-30.56μg mL-1 with determination coefficient of 0.99972. Recovery results in the range98.79–101.20% and low coefficient of variation values for intra-day and interdayprecisions (0.37% and 0.76%, respectively) showed the accuracy andreproducibility of the method. The method was used for determination ofchloroquine phosphate in tablet formulations of different brands. Results in therange 100.63–103.52% of the labeled chloroquine phosphate in tabletformulations confirmed the applicability of the developed method for real sampleanalysis. Hence, the developed UV-Vis method using environmentally friendlywater as a solvent, with an excellent accuracy and precision showed that thedeveloped method can be a potential substituent for the official referencemethods.

Simultaneous GLC Analysis of Aspirin and Nonaspirin Salicylates in Pharmaceutical Tablet Formulations

1981 ◽  
Vol 70 (2) ◽  
pp. 167-169 ◽  
Author(s):  
Robert N. Galantex ◽  
John C. Egoville ◽  
Anthony J. Visalli ◽  
Dahyabhai M. Patel
Keyword(s):  
Pharmaceutical Tablet ◽  
Tablet Formulations
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