scholarly journals Intradomain Interactions in an NMDA Receptor Fragment Mediate N-Glycan Processing and Conformational Sampling

Structure ◽  
2019 ◽  
Vol 27 (1) ◽  
pp. 55-65.e3 ◽  
Author(s):  
Ganesh P. Subedi ◽  
Anton V. Sinitskiy ◽  
Jacob T. Roberts ◽  
Kashyap R. Patel ◽  
Vijay S. Pande ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Conformational Sampling ◽  
Receptor Fragment

5-07-07 Autoantibodies to NMDA-receptor fragment in patients with ischemic stroke

1997 ◽  
Vol 150 ◽  
pp. S280
Author(s):  
Alexander A. Skoromets ◽  
Anna Yu. Ilyukhina ◽  
Svetlana A. Dambinova
Keyword(s):  
Ischemic Stroke ◽  
Nmda Receptor ◽  
Receptor Fragment

Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: the trimethylamine dehydrogenase-electron-transferring flavoprotein complex

2004 ◽  
Vol 71 ◽  
pp. 1-14
Author(s):  
David Leys ◽  
Jaswir Basran ◽  
François Talfournier ◽  
Kamaldeep K. Chohan ◽  
Andrew W. Munro ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Kinetic Studies ◽  
Molecular Assembly ◽  
Conformational Sampling ◽  
Trimethylamine Dehydrogenase ◽  
Key Residues ◽  
Electron Transferring Flavoprotein ◽  
Electron Transfer Complex

TMADH (trimethylamine dehydrogenase) is a complex iron-sulphur flavoprotein that forms a soluble electron-transfer complex with ETF (electron-transferring flavoprotein). The mechanism of electron transfer between TMADH and ETF has been studied using stopped-flow kinetic and mutagenesis methods, and more recently by X-ray crystallography. Potentiometric methods have also been used to identify key residues involved in the stabilization of the flavin radical semiquinone species in ETF. These studies have demonstrated a key role for 'conformational sampling' in the electron-transfer complex, facilitated by two-site contact of ETF with TMADH. Exploration of three-dimensional space in the complex allows the FAD of ETF to find conformations compatible with enhanced electronic coupling with the 4Fe-4S centre of TMADH. This mechanism of electron transfer provides for a more robust and accessible design principle for interprotein electron transfer compared with simpler models that invoke the collision of redox partners followed by electron transfer. The structure of the TMADH-ETF complex confirms the role of key residues in electron transfer and molecular assembly, originally suggested from detailed kinetic studies in wild-type and mutant complexes, and from molecular modelling.

Pharmacologic Regulation of the NMDA Receptor-lonophore Complex

1993 ◽  
Author(s):  
Kenneth M. Johnson ◽  
Lawrence D. Snell ◽  
Susan M. Jones ◽  
Aida I. Sacaan
Keyword(s):  
Nmda Receptor ◽  
Pharmacologic Regulation

Effect of NMDA receptor channel blockade on aggression in isolated male mice

1998 ◽  
Author(s):  
Irina Belozertseva ◽  
Anton Bespalov ◽  
Eugeny Gmiro ◽  
Wojciech Danysz ◽  
Edwin Zvartau
Keyword(s):  
Nmda Receptor ◽  
Male Mice ◽  
Channel Blockade ◽  
Nmda Receptor Channel ◽  
Receptor Channel
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