scholarly journals Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

2020 ◽  
Vol 27 (4) ◽  
pp. 590-604.e9 ◽  
Author(s):  
Priscilla Cheung ◽  
Jordi Xiol ◽  
Michael T. Dill ◽  
Wei-Chien Yuan ◽  
Riccardo Panero ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Metastatic Colorectal Cancer ◽  
Intestinal Stem Cell ◽  
Hippo Signaling ◽  
Cell State ◽  
Stem Cell State

805 SOX4 Drives Early Enteroendocrine Specification and Exit From the Intestinal Stem Cell State

2016 ◽  
Vol 150 (4) ◽  
pp. S170
Author(s):  
Adam D. Gracz ◽  
Daniel C. Trotier ◽  
Matthew J. Fordham ◽  
Scott Magness
Keyword(s):  
Stem Cell ◽  
Intestinal Stem Cell ◽  
Cell State ◽  
Stem Cell State

scholarly journals SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Ida V. Lundberg ◽  
Sofia Edin ◽  
Vincy Eklöf ◽  
Åke Öberg ◽  
Richard Palmqvist ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Down Regulation ◽  
Cell State ◽  
Sox2 Expression ◽  
Stem Cell State

Clonal Isolation of an Intermediate Pluripotent Stem Cell State

Stem Cells ◽  
2013 ◽  
Vol 31 (5) ◽  
pp. 918-927 ◽  
Author(s):  
Kuo-Hsuan Chang ◽  
Meng Li
Keyword(s):  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Cell State ◽  
Stem Cell State

HLF Expression Defines the Human Hematopoietic Stem Cell State.

Blood ◽  
2021 ◽  
Author(s):  
Bernhard Lehnertz ◽  
Jalila Chagraoui ◽  
Tara MacRae ◽  
Elisa Tomellini ◽  
Sophie Corneau ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Fetal Liver ◽  
Cell Activity ◽  
Mouse Strains ◽  
Marker Genes ◽  
Hematopoietic Stem ◽  
Cell State ◽  
Human Hscs ◽  
Stem Cell State

Hematopoietic stem cells (HSCs) sustain blood cell homeostasis throughout life and can regenerate all blood lineages following transplantation. Despite this clear functional definition, highly enriched isolation of human HSCs can currently only be achieved through combinatorial assessment of multiple surface antigens. While several transgenic HSC reporter mouse strains have been described, no analogous approach to prospectively isolate human HSCs has been reported. To identify genes with the most selective expression in human HSCs, we profiled population- and single-cell transcriptomes of un-expanded and ex vivo cultured cord blood-derived HSPCs as well as peripheral blood, adult bone marrow, and fetal liver. Based on these analyses, we propose the master transcription factor HLF (Hepatic Leukemia Factor) as one of the most specific HSC marker genes. To directly track its expression in human hematopoietic cells, we developed a genomic HLF reporter strategy, capable of selectively labeling the most immature blood cells based on a single engineered parameter. Most importantly, HLF-expressing cells comprise all of the stem cell activity in culture and in vivo during serial transplantation. Taken together, these results experimentally establish HLF as a defining gene of the human hematopoietic stem cell state and outline a new approach to continuously mark these cells with high fidelity.

scholarly journals Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division

2018 ◽  
Vol 32 (23-24) ◽  
pp. 1550-1561 ◽  
Author(s):  
Hideyuki Komori ◽  
Krista L. Golden ◽  
Taeko Kobayashi ◽  
Ryoichiro Kageyama ◽  
Cheng-Yu Lee
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Gene Control ◽  
Cell State ◽  
Stem Cell Division ◽  
Stem Cell State

scholarly journals Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer

2012 ◽  
Vol 13 (4) ◽  
pp. 4367-4387 ◽  
Author(s):  
Manuel Valladares-Ayerbes ◽  
Moisés Blanco-Calvo ◽  
Margarita Reboredo ◽  
María J. Lorenzo-Patiño ◽  
Pilar Iglesias-Díaz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Stem Cell Marker ◽  
Intestinal Stem Cell ◽  
Cell Marker

scholarly journals STEM-36. A TRANSLATIONAL REPRESSION PROGRAM IS ASSOCIATED WITH THE STEM CELL STATE IN GLIOBLASTOMA

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi233-vi233
Author(s):  
Christine Lee ◽  
Yunku Yeu ◽  
Ulf-peter Guenther ◽  
Tae Hyun Hwang ◽  
Eckhard Jankowsky ◽  
...  
Keyword(s):  
Stem Cell ◽  
Translational Repression ◽  
Cell State ◽  
Stem Cell State
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