scholarly journals Reconstitution of Mouse Spermatogonial Stem Cell Niches in Culture

2012 ◽  
Vol 11 (4) ◽  
pp. 567-578 ◽  
Author(s):  
Mito Kanatsu-Shinohara ◽  
Kimiko Inoue ◽  
Seiji Takashima ◽  
Masanori Takehashi ◽  
Narumi Ogonuki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Niches

scholarly journals Sertoli Cells Dictate Spermatogonial Stem Cell Niches in the Mouse Testis

2010 ◽  
Vol 84 (4) ◽  
pp. 639-645 ◽  
Author(s):  
M. J. Oatley ◽  
K. E. Racicot ◽  
J. M. Oatley
Keyword(s):  
Stem Cell ◽  
Sertoli Cells ◽  
Spermatogonial Stem Cell ◽  
Mouse Testis ◽  
Stem Cell Niches

scholarly journals A magic kick for regeneration: role of mesenchymal stromal cell secretome in spermatogonial stem cell niche recovery

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Georgy Sagaradze ◽  
Nataliya Basalova ◽  
Vladimir Kirpatovsky ◽  
Dmitry Ohobotov ◽  
Peter Nimiritsky ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Abdominal Cavity ◽  
Spermatogonial Stem Cell ◽  
Target Cells ◽  
Regenerative Processes ◽  
Cell Niche ◽  
Stem Cell Niches ◽  
Supportive Cells

Abstract Background Injury of stem cell niches may disturb tissue homeostasis and regeneration coordinated by specific niche components. Yet, the mechanisms of stem cell niche restoration remain poorly understood. Herein, we examined the role of mesenchymal stromal cells (MSCs) as pivotal regulators of stem cell niche recovery focusing on the effects of their secretome. Methods The spermatogonial stem cell (SSC) niche was selected as a model. SSC niches were injured by inducing abdominal cryptorchidism in rats. Briefly, testes of anesthetized rats were elevated into the abdominal cavity through the inguinal canal for 14 days. After descent of testes, MSC or MSC secretome treatment was applied to the animals by local subtunical injections. Results Local administration of MSC or MSC secretome was sufficient to recover spermatogenesis and production of functional germ cells. The effects of MSC and their secreted components were comparable, leading to restoration of Sertoli cell pools and recovery of Leydig cell secretory functions. Conclusion Our data suggest that MSCs mimic the functions of lost supportive cells within the stem cell niche, transiently providing paracrine stimuli for target cells and triggering tissue regenerative processes after damage.

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

scholarly journals Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice

2021 ◽  
Author(s):  
Yoshiaki Nakamura ◽  
David J. Jörg ◽  
Yayoi Kon ◽  
Benjamin D. Simons ◽  
Shosei Yoshida
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Spermatogonial Stem Cell

scholarly journals Evidence for lung epithelial stem cell niches

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Matt L. Donne ◽  
Andrew J. Lechner ◽  
Jason R. Rock
Keyword(s):  
Stem Cell ◽  
Epithelial Stem Cell ◽  
Lung Epithelial ◽  
Stem Cell Niches

Adhesion within the stem cell niches

2009 ◽  
Vol 21 (5) ◽  
pp. 623-629 ◽  
Author(s):  
Karine Raymond ◽  
Marie-Ange Deugnier ◽  
Marisa M Faraldo ◽  
Marina A Glukhova
Keyword(s):  
Stem Cell ◽  
Stem Cell Niches

scholarly journals Can pubertal boys with Klinefelter syndrome benefit from spermatogonial stem cell banking?

2011 ◽  
Vol 27 (2) ◽  
pp. 323-330 ◽  
Author(s):  
D. Van Saen ◽  
I. Gies ◽  
J. De Schepper ◽  
H. Tournaye ◽  
E. Goossens
Keyword(s):  
Stem Cell ◽  
Klinefelter Syndrome ◽  
Spermatogonial Stem Cell ◽  
Cell Banking ◽  
Pubertal Boys ◽  
Stem Cell Banking
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