scholarly journals Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

2011 ◽  
Vol 9 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Ori Bar-Nur ◽  
Holger A. Russ ◽  
Shimon Efrat ◽  
Nissim Benvenisty
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Beta Cells ◽  
Pancreatic Islet ◽  
Pluripotent Stem Cells ◽  
Epigenetic Memory ◽  
Islet Beta Cells ◽  
Human Pancreatic Islet ◽  
Pancreatic Islet Beta Cells ◽  
Induced Pluripotent

scholarly journals Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas

2015 ◽  
Vol 20 (5) ◽  
pp. 367-381 ◽  
Author(s):  
Daiki Nukaya ◽  
Kohtaro Minami ◽  
Ritsuko Hoshikawa ◽  
Norihide Yokoi ◽  
Susumu Seino
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Epigenetic Memory ◽  
Mouse Pancreas ◽  
Induced Pluripotent

scholarly journals “Epigenetic Memory” Phenomenon in Induced Pluripotent Stem Cells

Acta Naturae ◽  
2013 ◽  
Vol 5 (4) ◽  
pp. 15-21 ◽  
Author(s):  
E. A. Vaskova ◽  
A. E. Stekleneva ◽  
S. P. Medvedev ◽  
S. M. Zakian
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Embryonic Stem ◽  
Somatic Tissue ◽  
Epigenetic Memory ◽  
High Throughput Analysis ◽  
Tissue Of Origin ◽  
Induced Pluripotent ◽  
Covalent Histone Modifications

To date biomedicine and pharmacology have required generating new and more consummate models. One of the most perspective trends in this field is using induced pluripotent stem cells (iPSCs). iPSC application requires careful high-throughput analysis at the molecular, epigenetic, and functional levels. The methods used have revealed that the expression pattern of genes and microRNA, DNA methylation, as well as the set and pattern of covalent histone modifications in iPSCs, are very similar to those in embryonic stem cells. Nevertheless, iPSCs have been shown to possess some specific features that can be acquired during the reprogramming process or are remnants of epigenomes and transcriptomes of the donor tissue. These residual signatures of epigenomes and transcriptomes of the somatic tissue of origin were termed epigenetic memory. In this review, we discuss the epigenetic memory phenomenon in the context of the reprogramming process, its influence on iPSC properties, and the possibilities of its application in cell technologies.

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