scholarly journals Brain Area-Specific Effect of TGF-β Signaling on Wnt-Dependent Neural Stem Cell Expansion

2008 ◽  
Vol 2 (5) ◽  
pp. 472-483 ◽  
Author(s):  
Sven Falk ◽  
Heiko Wurdak ◽  
Lars M. Ittner ◽  
Fabian Ille ◽  
Grzegorz Sumara ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Brain Area ◽  
Specific Effect ◽  
Stem Cell Expansion

scholarly journals Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

2013 ◽  
Vol 12 (1) ◽  
pp. 88-100 ◽  
Author(s):  
M. Ángeles Marqués-Torrejón ◽  
Eva Porlan ◽  
Ana Banito ◽  
Esther Gómez-Ibarlucea ◽  
Andrés J. Lopez-Contreras ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Adult Neural Stem Cell ◽  
Stem Cell Expansion ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Sox2 Gene

scholarly journals MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex

Cell Reports ◽  
2013 ◽  
Vol 3 (5) ◽  
pp. 1398-1406 ◽  
Author(s):  
Shan Bian ◽  
Janet Hong ◽  
Qingsong Li ◽  
Laura Schebelle ◽  
Andrew Pollock ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Stem Cell Expansion ◽  
Intermediate Progenitors ◽  
Microrna Cluster

scholarly journals Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion

2014 ◽  
Vol 289 (8) ◽  
pp. 4626-4633 ◽  
Author(s):  
Amber N. Ziegler ◽  
Shravanthi Chidambaram ◽  
Briony E. Forbes ◽  
Teresa L. Wood ◽  
Steven W. Levison
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Insulin Receptor ◽  
Binding Affinity ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Insulin Like Growth Factor ◽  
Stem Cell Expansion ◽  
Factor Ii

scholarly journals Transcriptional regulation of neural stem cell expansion in adult hippocampus

2021 ◽  
Author(s):  
Nannan Guo ◽  
Kelsey McDermott ◽  
Yu-Tzu Shih ◽  
Haley Zanga ◽  
Debolina Ghosh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Self Renewal ◽  
Stem Cell Expansion ◽  
Radial Glial ◽  
Adult Hippocampus ◽  
Favorable Conditions

Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors in RGLs integrate physiological signals to dictate self-renewal division mode. Whereas asymmetric RGL divisions drive neurogenesis during favorable conditions, symmetric divisions prevent premature neurogenesis while amplifying RGLs to anticipate future neurogenic demands. The identities of transcription factors regulating RGL symmetric self-renewal, unlike those that regulate RGL asymmetric self-renewal, are not known. Here, we show that the transcription factor Kruppel-like factor 9 (Klf9) is elevated in quiescent RGLs and inducible, deletion of Klf9 promotes RGL activation state. Clonal analysis and longitudinal intravital 2-photon imaging directly demonstrate that Klf9 functions as a brake on RGL symmetric self-renewal. In vivo translational profiling of RGLs lacking Klf9 generated a blueprint of RGL symmetric self-renewal for stem cell community. Together, these observations identify Klf9 as a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

scholarly journals The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Chan-Il Choi ◽  
Hyesook Yoon ◽  
Kristen L. Drucker ◽  
Monica R. Langley ◽  
Laurel Kleppe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Subventricular Zone ◽  
Cell Expansion ◽  
Thrombin Receptor ◽  
Stem Cell Expansion

scholarly journals Transcriptional regulation of neural stem cell expansion in adult hippocampus

eLife ◽  
2022 ◽  
Vol 11 ◽  
Author(s):  
Nannan Guo ◽  
Kelsey D McDermott ◽  
Yu-Tzu Shih ◽  
Haley Zanga ◽  
Debolina Ghosh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Acid Oxidation ◽  
Self Renewal ◽  
Stem Cell Expansion ◽  
Adult Hippocampus ◽  
Favorable Conditions

Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors in RGLs integrate physiological signals to dictate self-renewal division mode. Whereas asymmetric RGL divisions drive neurogenesis during favorable conditions, symmetric divisions prevent premature neurogenesis while amplifying RGLs to anticipate future neurogenic demands. The identities of transcription factors regulating RGL symmetric self-renewal, unlike those that regulate RGL asymmetric self-renewal, are not known. Here, we show in mice that the transcription factor Kruppel-like factor 9 (Klf9) is elevated in quiescent RGLs and inducible, deletion of Klf9 promotes RGL activation state. Clonal analysis and longitudinal intravital 2-photon imaging directly demonstrate that Klf9 functions as a brake on RGL symmetric self-renewal. In vivo translational profiling of RGLs lacking Klf9 generated a molecular blueprint for RGL symmetric self-renewal that was characterized by upregulation of genetic programs underlying Notch and mitogen signaling, cell-cycle, fatty acid oxidation and lipogenesis. Together, these observations identify Klf9 as a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

scholarly journals The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation

2010 ◽  
Vol 24 (7) ◽  
pp. 683-695 ◽  
Author(s):  
H. K. Liu ◽  
Y. Wang ◽  
T. Belz ◽  
D. Bock ◽  
A. Takacs ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Tumor ◽  
Neural Stem Cell ◽  
Nuclear Receptor ◽  
Cell Expansion ◽  
Tumor Initiation ◽  
Stem Cell Expansion
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