scholarly journals Unraveling Epigenetic Regulation in Embryonic Stem Cells

2008 ◽  
Vol 2 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Marina Bibikova ◽  
Louise C. Laurent ◽  
Bing Ren ◽  
Jeanne F. Loring ◽  
Jian-Bing Fan
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Embryonic Stem

scholarly journals Epigenetic Regulation of miR-302 by JMJD1C Inhibits Neural Differentiation of Human Embryonic Stem Cells

2013 ◽  
Vol 289 (4) ◽  
pp. 2384-2395 ◽  
Author(s):  
Jianle Wang ◽  
Jung W. Park ◽  
Hicham Drissi ◽  
Xiaofang Wang ◽  
Ren-He Xu
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Neural Differentiation ◽  
Embryonic Stem

scholarly journals Differentiation of Mouse Embryonic Stem Cells toward Functional Pancreatic β-Cell Surrogates through Epigenetic Regulation of Pdx1 by Nitric Oxide

2016 ◽  
Vol 25 (10) ◽  
pp. 1879-1892 ◽  
Author(s):  
Carmen Salguero-Aranda ◽  
Rafael Tapia-Limonchi ◽  
Gladys Margot Cahuana ◽  
Ana Belen Hitos ◽  
Irene Diaz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Pancreatic Β Cell ◽  
Β Cell

scholarly journals Genome-wide identification and characterisation of HOT regions in the human genome

2016 ◽  
Author(s):  
Hao Li ◽  
Feng Liu ◽  
Chao Ren ◽  
Xiaochen Bo ◽  
Wenjie Shu
Keyword(s):  
Stem Cells ◽  
Transcription Factors ◽  
Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Human Cell ◽  
Embryonic Stem ◽  
Cell Types ◽  
Genome Wide ◽  
Development And Differentiation ◽  
Epigenetic Analysis

AbstractHOT (high-occupancy target) regions, which are bound by a surprisingly large number of transcription factors, are considered to be among the most intriguing findings of recent years. An improved understanding of the roles that HOT regions play in biology would be afforded by knowing the constellation of factors that constitute these domains and by identifying HOT regions across the spectrum of human cell types. We characterised and validated HOT regions in embryonic stem cells (ESCs) and produced a catalogue of HOT regions in a broad range of human cell types. We found that HOT regions are associated with genes that control and define the developmental processes of the respective cell and tissue types. We also showed evidence of the developmental persistence of HOT regions at primitive enhancers and demonstrate unique signatures of HOT regions that distinguish them from typical enhancers and super-enhancers. Finally, we performed an epigenetic analysis to reveal the dynamic epigenetic regulation of HOT regions upon H1 differentiation. Taken together, our results provide a resource for the functional exploration of HOT regions and extend our understanding of the key roles of HOT regions in development and differentiation.

scholarly journals Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells

2021 ◽  
Vol 22 (16) ◽  
pp. 8599
Author(s):  
Yong-Jin Kim ◽  
Amin Tamadon ◽  
Yoon-Young Kim ◽  
Byeong-Cheol Kang ◽  
Seung-Yup Ku
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Epigenetic Regulation ◽  
Pluripotent Stem Cells ◽  
Embryonic Stem ◽  
Terminal Differentiation ◽  
Fetal Life ◽  
Cardiac Lineage ◽  
Induced Pluripotent

With the intent to achieve the best modalities for myocardial cell therapy, different cell types are being evaluated as potent sources for differentiation into cardiomyocytes. Embryonic stem cells and induced pluripotent stem cells have great potential for future progress in the treatment of myocardial diseases. We reviewed aspects of epigenetic mechanisms that play a role in the differentiation of these cells into cardiomyocytes. Cardiomyocytes proliferate during fetal life, and after birth, they undergo permanent terminal differentiation. Upregulation of cardiac-specific genes in adults induces hypertrophy due to terminal differentiation. The repression or expression of these genes is controlled by chromatin structural and epigenetic changes. However, few studies have reviewed and analyzed the epigenetic aspects of the differentiation of embryonic stem cells and induced pluripotent stem cells into cardiac lineage cells. In this review, we focus on the current knowledge of epigenetic regulation of cardiomyocyte proliferation and differentiation from embryonic and induced pluripotent stem cells through histone modification and microRNAs, the maintenance of pluripotency, and its alteration during cardiac lineage differentiation.

scholarly journals Human Embryonic Stem Cells as a Model for Studying Epigenetic Regulation During Early Development

Cell Cycle ◽  
2005 ◽  
Vol 4 (10) ◽  
pp. 1323-1326 ◽  
Author(s):  
Peter J. Rugg-Gunn ◽  
Anne C. Ferguson-Smith ◽  
Roger A. Pedersen
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Early Development ◽  
Human Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Embryonic Stem
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