scholarly journals Epigenetic Regulation of Neural Differentiation from Embryonic Stem Cells

10.5772/53650 ◽  
2013 ◽  
Author(s):  
Atsushi Shimomura ◽  
Eri Hashino
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Neural Differentiation ◽  
Embryonic Stem

scholarly journals Epigenetic Regulation of miR-302 by JMJD1C Inhibits Neural Differentiation of Human Embryonic Stem Cells

2013 ◽  
Vol 289 (4) ◽  
pp. 2384-2395 ◽  
Author(s):  
Jianle Wang ◽  
Jung W. Park ◽  
Hicham Drissi ◽  
Xiaofang Wang ◽  
Ren-He Xu
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Neural Differentiation ◽  
Embryonic Stem

Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells

2013 ◽  
Vol 91 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Maryam Shahhoseini ◽  
Zeinab Taghizadeh ◽  
Maryam Hatami ◽  
Hossein Baharvand
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Epigenetic Regulation ◽  
Neural Differentiation ◽  
Hox Genes ◽  
Embryonic Stem ◽  
Model Systems ◽  
Hox Clusters

Gene activation of HOX clusters is an early event in embryonic development. These genes are highly expressed and active in the vertebrate nervous system. Based on the presence of retinoic acid response elements (RAREs) in the regulatory region of many of the HOX genes, it is deduced that retinoic acid (RA) can influence epigenetic regulation and consequently the expression pattern of HOX during RA-induced differentiation of embryonic model systems. In this investigation, the expression level as well as the epigenetic regulation of several HOX genes of the 4 A–D clusters was analyzed in human embryonic stem cells, and also through their neural induction, in the presence and absence of RA. Expression analysis data significantly showed increased mRNA levels of all examined HOX genes in the presence of RA. Epigenetic analysis of the HOX gene regulatory regions also showed a significant decrease in methylation of histone H3K27 parallel to an absolute preferential incorporation of the demethylase UTX rather than JMJD3 in RA-induced neural differentiated cells. This finding clearly showed the functional role of UTX in epigenetic alteration of HOX clusters during RA-induced neural differentiation; the activity could not be detectable for the demethylase JMJD3 during this developmental process.

Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal

2019 ◽  
Vol 508 (3) ◽  
pp. 907-913 ◽  
Author(s):  
SoJung An ◽  
Ui-Hyun Park ◽  
Seungtae Moon ◽  
Myengmo Kang ◽  
Hyesook Youn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neural Differentiation ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Self Renewal

scholarly journals PCGF5 is required for neural differentiation of embryonic stem cells

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Mingze Yao ◽  
Xueke Zhou ◽  
Jiajian Zhou ◽  
Shixin Gong ◽  
Gongcheng Hu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neural Differentiation ◽  
Embryonic Stem

scholarly journals RGD-Functionalized Nanofibers Increase Early GFAP Expression during Neural Differentiation of Mouse Embryonic Stem Cells

2019 ◽  
Vol 20 (3) ◽  
pp. 1443-1454 ◽  
Author(s):  
Diana L. Philip ◽  
Elena A. Silantyeva ◽  
Matthew L. Becker ◽  
Rebecca K. Willits
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neural Differentiation ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Gfap Expression
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