Adaptive FWER control procedure for grouped hypotheses

2014 ◽  
Vol 95 ◽  
pp. 63-70 ◽  
Author(s):  
Haibing Zhao
Keyword(s):  
Control Procedure ◽  
Grouped Hypotheses

scholarly journals 2dFDR: a new approach to confounder adjustment substantially increases detection power in omics association studies

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sangyoon Yi ◽  
Xianyang Zhang ◽  
Lu Yang ◽  
Jinyan Huang ◽  
Yuanhang Liu ◽  
...  
Keyword(s):  
Multiple Testing ◽  
Statistical Power ◽  
Association Studies ◽  
Control Procedure ◽  
Multiple Testing Correction ◽  
New Approach ◽  
False Discovery ◽  
Traditional Procedure ◽  
Extensive Evaluation ◽  
Confounder Adjustment

AbstractOne challenge facing omics association studies is the loss of statistical power when adjusting for confounders and multiple testing. The traditional statistical procedure involves fitting a confounder-adjusted regression model for each omics feature, followed by multiple testing correction. Here we show that the traditional procedure is not optimal and present a new approach, 2dFDR, a two-dimensional false discovery rate control procedure, for powerful confounder adjustment in multiple testing. Through extensive evaluation, we demonstrate that 2dFDR is more powerful than the traditional procedure, and in the presence of strong confounding and weak signals, the power improvement could be more than 100%.

scholarly journals Diagnostics and Prognostics of Energy Conversion Processes via Knowledge-Based Systems

Proceedings ◽  
2020 ◽  
Vol 58 (1) ◽  
pp. 1
Author(s):  
Roberto Melli ◽  
Enrico Sciubba
Keyword(s):  
Expert System ◽  
Knowledge Base ◽  
Real Time ◽  
System Analysis ◽  
Intelligent System ◽  
Time Derivative ◽  
Time History ◽  
Control Procedure ◽  
Time Data ◽  
Ongoing Research

This paper presents a critical and analytical description of an ongoing research program aimed at the implementation of an expert system capable of monitoring, through an Intelligent Health Control procedure, the instantaneous performance of a cogeneration plant. The expert system is implemented in the CLIPS environment and is denominated PROMISA as the acronym for Prognostic Module for Intelligent System Analysis. It generates, in real time and in a form directly useful to the plant manager, information on the existence and severity of faults, forecasts on the future time history of both detected and likely faults, and suggestions on how to control the problem. The expert procedure, working where and if necessary with the support of a process simulator, derives from the available real-time data a list of selected performance indicators for each plant component. For a set of faults, pre-defined with the help of the plant operator (Domain Expert), proper rules are defined in order to establish whether the component is working correctly; in several instances, since one single failure (symptom) can originate from more than one fault (cause), complex sets of rules expressing the combination of multiple indices have been introduced in the knowledge base as well. Creeping faults are detected by analyzing the trend of the variation of an indicator over a pre-assigned interval of time. Whenever the value of this ‘‘discrete time derivative’’ becomes ‘‘high’’ with respect to a specified limit value, a ‘‘latent creeping fault’’ condition is prognosticated. The expert system architecture is based on an object-oriented paradigm. The knowledge base (facts and rules) is clustered—the chunks of knowledge pertain to individual components. A graphic user interface (GUI) allows the user to interrogate PROMISA about its rules, procedures, classes and objects, and about its inference path. The paper also presents the results of some simulation tests.

scholarly journals Selectively Interfering With Intrusive but Not Voluntary Memories of a Trauma Film: Accounting for the Role of Associative Memory

2021 ◽  
pp. 216770262199831
Author(s):  
Alex Lau-Zhu ◽  
Richard N. Henson ◽  
Emily A. Holmes
Keyword(s):  
Emotional Disorders ◽  
Traumatic Event ◽  
Emotional Memory ◽  
Control Procedure ◽  
Witness Testimony ◽  
Intrusive Memories ◽  
Therapeutic Benefits ◽  
Selective Interference ◽  
Intrusive Memory

Intrusive memories of a traumatic event can be reduced by a subsequent interference procedure, seemingly sparing voluntary memory for that event. This selective-interference effect has potential therapeutic benefits (e.g., for emotional disorders) and legal importance (e.g., for witness testimony). However, the measurements of intrusive memory and voluntary memory typically differ in the role of associations between a cue and the emotional memory “hotspots.” To test this, we asked participants to watch a traumatic film followed by either an interference procedure (reminder plus Tetris) or control procedure (reminder only). Measurement of intrusions (using a laboratory task) and voluntary memory (recognition for film stills) were crossed with the presence or absence of associative cues. The reminder-plus-Tetris group exhibited fewer intrusions despite comparable recognition memory, replicating the results of prior studies. Note that this selective interference did not appear to depend on associative cues. This involuntary versus voluntary memory dissociation for emotional material further supports separate-trace memory theories and has applied advantages.

scholarly journals A Combined Forecast-Inventory Control Procedure for Spare Parts

2000 ◽  
Vol 51 (10) ◽  
pp. 1184 ◽  
Author(s):  
L. W. G. Strijbosch ◽  
R. M. J. Heuts ◽  
E. H. M. van der Schoot
Keyword(s):  
Inventory Control ◽  
Spare Parts ◽  
Control Procedure

Olfactory Aversion Conditioning and Overeating: A Review and Some Data

1983 ◽  
Vol 57 (2) ◽  
pp. 667-678 ◽  
Author(s):  
Anthony D. Cole ◽  
Nigel W. Bond
Keyword(s):  
Treatment Period ◽  
Therapy Group ◽  
Treatment Phase ◽  
Placebo Control ◽  
Control Procedure ◽  
Treatment Conditions ◽  
Weekly Session ◽  
Aversion Conditioning ◽  
Contact Control ◽  
The Difference

The present study evaluated the efficacy of olfactory aversion conditioning in the management of overeating problems. 42 overweight female subjects were assigned to one of three treatment conditions: olfactory aversion therapy, attention placebo control, and no-contact control. One experimenter administered the 8-wk. treatment phase. The aversion therapy procedure entailed the pairing of selected target foods (CSs) with noxious odors (UCSs). There were 25 pairings of the CS and UCSs during each weekly session. Four noxious odors were employed, one each week, to prevent habituation to the UCS. The attention-placebo control procedure was identical except that “air” was substituted for the putative UCS of the aversion therapy condition. At the end of the treatment period the aversion therapy group had lost 4.7 lb.; the attention placebo controls had lost 3.6 lb. and the no-contact controls 0.5 lb. The difference between the aversion therapy group and the no-contact controls was significant and that between the attention placebo group and the no-contact controls approached significance. At a follow-up 8 wk. after the end of the treatment period the weights of all groups had risen to pretreatment levels and there were no differences between them. These results indicate that olfactory aversion therapy is not an efficient technique in promoting weight-loss.

Comparison of Prompting Techniques to Teach Children With Autism to Ask Questions in the Context of a Conversation

2015 ◽  
Vol 32 (2) ◽  
pp. 93-101 ◽  
Author(s):  
Matthew G. Swerdan ◽  
Rocío Rosales
Keyword(s):  
Stimulus Control ◽  
Children With Autism ◽  
Future Research ◽  
Control Procedure ◽  
Transfer Of Stimulus Control ◽  
Alternating Treatments Design ◽  
Textual Prompts ◽  
Students With Autism ◽  
Adapted Alternating Treatments Design

An adapted alternating treatments design was used to compare the efficacy of echoic and textual prompts to teach three students with autism (ages 8–15) to ask questions related to two pre-selected topics of conversation. Participants were first required to answer questions related to the topics to determine whether accurate responses were within their repertoire. This was followed by a transfer of stimulus control procedure to teach participants to ask relevant questions to the experimenter on the same topics. Probes with a novel conversation topic were conducted in the natural environment with a peer, and follow-up probes were conducted after training. Results indicate questions taught using an echoic prompt were acquired in fewer trials to criterion than questions taught using a textual prompt for two of the three participants. Limitations and implications for future research will be discussed.

scholarly journals A Coefficient Diagram Method Controller with Backstepping Methodology for Robotic Manipulators

2015 ◽  
Vol 66 (5) ◽  
pp. 270-276 ◽  
Author(s):  
Fouad Haouari ◽  
Bali Nourdine ◽  
Mohamed Segir Boucherit ◽  
Mohamed Tadjine
Keyword(s):  
Robotic Manipulators ◽  
Control Law ◽  
Control Procedure ◽  
Parametric Uncertainties ◽  
The Novel ◽  
External Disturbances ◽  
Diagram Method ◽  
Coefficient Diagram Method ◽  
Backstepping Controller ◽  
Puma Robot

AbstractA new robust control procedure for robot manipulators is proposed in this paper. Coefficients diagram method controllers CDM and Backstepping methodology are combined to create the novel control law. Two steps of backstepping on the resulting system are used to design a nonlinear CDM-Backstepping controller. Simulations on a PUMA robot including external disturbances, parametric uncertainties and noises are performed to show the effectiveness and feasibility of the proposed method.

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