scholarly journals Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy

2019 ◽  
Vol 28 (3) ◽  
pp. 489-504
Author(s):  
Sunny J. Patel ◽  
Takayoshi Yamauchi ◽  
Fumito Ito
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Cancer Immunotherapy ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Induced Pluripotent

Induced pluripotent stem cell‐derived myeloid cells expressing OX40 ligand amplify antigen‐specific T cells in advanced melanoma

2020 ◽  
Vol 33 (5) ◽  
pp. 744-755
Author(s):  
Toshihiro Kimura ◽  
Satoshi Fukushima ◽  
Etsuko Okada ◽  
Haruka Kuriyama ◽  
Hisashi Kanemaru ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Myeloid Cells ◽  
Induced Pluripotent Stem Cell ◽  
Advanced Melanoma ◽  
Ox40 Ligand ◽  
Induced Pluripotent

scholarly journals Induced Pluripotent Stem Cell as a New Source for Cancer Immunotherapy

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Farzaneh Rami ◽  
Halimeh Mollainezhad ◽  
Mansoor Salehi
Keyword(s):  
Stem Cell ◽  
Immune System ◽  
Cancer Immunotherapy ◽  
Immune Cells ◽  
Pluripotent Stem Cell ◽  
Ex Vivo ◽  
Embryonic Stem ◽  
Induced Pluripotent Stem Cell ◽  
Protective Function ◽  
Induced Pluripotent

The immune system consists of cells, proteins, and other molecules that beside each other have a protective function for the host against foreign pathogens. One of the most essential features of the immune system is distinguishability between self- and non-self-cells. This function has an important role in limiting development and progression of cancer cells. In this case, the immune system can detect tumor cell as a foreign pathogen; so, it can be effective in elimination of tumors in their early phases of development. This ability of the immune system resulted in the development of a novel therapeutic field for cancer treatment using host immune components which is called cancer immunotherapy. The main purpose of cancer immunotherapy is stimulation of a strong immune response against the tumor cells that can result from expressing either the immune activator cytokines in the tumor area or gene-modified immune cells. Because of the problems of culturing and manipulating immune cells ex vivo, in recent years, embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) have been used as new sources for generation of modified immune stimulatory cells. In this paper, we reviewed some of the progressions in iPSC technology for cancer immunotherapy.

scholarly journals Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes

Diabetologia ◽  
2019 ◽  
Vol 62 (12) ◽  
pp. 2245-2251 ◽  
Author(s):  
Kriti Joshi ◽  
Colleen Elso ◽  
Ali Motazedian ◽  
Tanya Labonne ◽  
Jacqueline V. Schiesser ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Stem Cell ◽  
T Cell ◽  
T Cell Receptors ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Cell Receptors ◽  
Induced Pluripotent

Abstract Aims/hypothesis Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the characterisation of islet-infiltrating CD4+ T cells from a deceased organ donor who had type 1 diabetes. Methods Induced pluripotent stem cell (iPSC) lines derived from the above donor were differentiated into CD14+ macrophages and tested for their capacity to present antigen to T cell receptors (TCRs) derived from islet-infiltrating CD4+ T cells from the same donor. Results The iPSC macrophages displayed typical macrophage morphology, surface markers (CD14, CD86, CD16 and CD11b) and were phagocytic. In response to IFNγ treatment, iPSC macrophages upregulated expression of HLA class II, a characteristic that correlated with their capacity to present epitopes derived from proinsulin C-peptide to a T cell line expressing TCRs derived from islet-infiltrating CD4+ T cells of the original donor. T cell activation was specifically blocked by anti-HLA-DQ antibodies but not by antibodies directed against HLA-DR. Conclusions/interpretation This study provides a proof of principle for the use of iPSC-derived immune cells for modelling key cellular interactions in human type 1 diabetes.

Use of 3D culture systems to generate human induced pluripotent stem cell-derived [beta]-cells in vitro

2018 ◽  
Author(s):  
Fantuzzi Federica ◽  
Toivonen Sanna ◽  
Schiavo Andrea Alex ◽  
Pachera Nathalie ◽  
Rajaei Bahareh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Beta Cells ◽  
Pluripotent Stem Cell ◽  
3D Culture ◽  
Induced Pluripotent Stem Cell ◽  
Culture Systems ◽  
Induced Pluripotent
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