P345 Prevalence of sleep disordered breathing in subjects with metabolic syndrome

2006 ◽  
Vol 7 ◽  
pp. S63-S64
Author(s):  
Maree Barnes ◽  
George Jerums ◽  
David Hare ◽  
Allison Collins ◽  
Sianna Panagiotopoulos ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Sleep Disordered Breathing ◽  
Disordered Breathing

scholarly journals Association between Metabolic Syndrome and Sleep-disordered Breathing in Adolescents

2007 ◽  
Vol 176 (4) ◽  
pp. 401-408 ◽  
Author(s):  
Susan Redline ◽  
Amy Storfer-Isser ◽  
Carol L. Rosen ◽  
Nathan L. Johnson ◽  
H. Lester Kirchner ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Sleep Disordered Breathing ◽  
Disordered Breathing

Sleep-disordered breathing, type 2 diabetes and the metabolic syndrome

2014 ◽  
Vol 11 (4) ◽  
pp. 257-275 ◽  
Author(s):  
Ian W Seetho ◽  
John PH Wilding
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Sleep Disordered Breathing ◽  
Sleep Apnoea ◽  
The Metabolic Syndrome ◽  
Sleep Homeostasis ◽  
Obstructive Sleep ◽  
Underlying Mechanisms ◽  
Disordered Breathing

Sleep-disordered breathing (SDB) encompasses a spectrum of conditions that can lead to altered sleep homeostasis. In particular, obstructive sleep apnoea (OSA) is the most common form of SDB and is associated with adverse cardiometabolic manifestations including hypertension, metabolic syndrome and type 2 diabetes, ultimately increasing the risk of cardiovascular disease. The pathophysiological basis of these associations may relate to repeated intermittent hypoxia and fragmented sleep episodes that characterize OSA which drive further mechanisms with adverse metabolic and cardiovascular consequences. The associations of OSA with type 2 diabetes and the metabolic syndrome have been described in studies ranging from epidemiological and observational studies to controlled trials investigating the effects of OSA therapy with continuous positive airway pressure (CPAP). In recent years, there have been rising prevalence rates of diabetes and obesity worldwide. Given the established links between SDB (in particular OSA) with both conditions, understanding the potential influence of OSA on the components of the metabolic syndrome and diabetes and the underlying mechanisms by which such interactions may contribute to metabolic dysregulation are important in order to effectively and holistically manage patients with SDB, type 2 diabetes or the metabolic syndrome. In this article, we review the literature describing the associations, the possible underlying pathophysiological mechanisms linking these conditions and the effects of interventions including CPAP treatment and weight loss.

scholarly journals Combined Effects of Sleep Disordered Breathing and Metabolic Syndrome on Endothelial Function: The Wisconsin Sleep Cohort Study

SLEEP ◽  
2014 ◽  
Vol 37 (10) ◽  
pp. 1707-1713 ◽  
Author(s):  
Claudia E. Korcarz ◽  
James H. Stein ◽  
Paul E. Peppard ◽  
Terry B. Young ◽  
Jodi H. Barnet ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Endothelial Function ◽  
Sleep Disordered Breathing ◽  
Combined Effects ◽  
Disordered Breathing

Sleep-Disordered Breathing and the Metabolic Syndrome in Overweight and Obese Children and Adolescents

2007 ◽  
Vol 150 (6) ◽  
pp. 608-612 ◽  
Author(s):  
S.L. Verhulst ◽  
N. Schrauwen ◽  
D. Haentjens ◽  
R.P. Rooman ◽  
L. Van Gaal ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Sleep Disordered Breathing ◽  
Obese Children ◽  
The Metabolic Syndrome ◽  
Disordered Breathing

scholarly journals Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity

2020 ◽  
Vol 105 (4) ◽  
pp. e1827-e1834 ◽  
Author(s):  
Stacey Simon ◽  
Haseeb Rahat ◽  
Anne-Marie Carreau ◽  
Yesenia Garcia-Reyes ◽  
Ann Halbower ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Sleep Disordered Breathing ◽  
Polycystic Ovary ◽  
Liver Fat ◽  
Apnea Hypopnea Index ◽  
Poor Sleep ◽  
Sleep Health ◽  
Or Efficiency ◽  
Sleep Behaviors ◽  
Disordered Breathing

Abstract Context Polycystic ovary syndrome (PCOS) is a common endocrine disorder and is associated with metabolic syndrome (MS). Development of MS in PCOS is likely multifactorial and may relate to poor sleep. Objective The objective of this research is to investigate differences in objective markers of sleep in adolescents with obesity and PCOS with and without MS. We also aimed to examine the relationships between markers of sleep with MS markers. Design A cross-sectional study was conducted. Participants Participants included adolescents with PCOS and obesity with MS (N = 30) or without MS (N = 36). Outcome Measures Hormone and metabolic measurements, abdominal magnetic resonance imaging for hepatic fat fraction, actigraphy to estimate sleep, and overnight polysomnography (PSG). Results Adolescents with obesity and PCOS who also had MS had significantly worse sleep-disordered breathing including higher apnea-hypopnea index (AHI, P = .02) and arousal index (P = .01) compared to those without MS. Actigraphy showed no differences in habitual patterns of sleep behaviors including duration, timing, or efficiency between groups. However, a greater number of poor sleep health behaviors was associated with greater number of MS components (P = .04). Higher AHI correlated with higher triglycerides (TG) (r = 0.49, P = .02), and poorer sleep efficiency correlated with higher percentage of liver fat (r = –0.40, P = .01), waist circumference (r = –0.46, P < .01) and higher TG (r = –0.34, P = .04). Conclusions Among girls with PCOS and obesity, sleep-disordered breathing was more prevalent in those with MS, and poor sleep behaviors were associated with metabolic dysfunction and more MS symptoms. Sleep health should be included in the assessment of adolescents with PCOS and obesity.

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