Extracellular matrix and integrin signaling in lens development and cataract

2006 ◽  
Vol 17 (6) ◽  
pp. 759-776 ◽  
Author(s):  
Elizabeth D. Wederell ◽  
Robb U. de Iongh
Keyword(s):  
Extracellular Matrix ◽  
Integrin Signaling ◽  
Lens Development

scholarly journals A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes

2018 ◽  
Vol 6 (3) ◽  
pp. 20 ◽  
Author(s):  
Paige Drake ◽  
Tamara Franz-Odendaal
Keyword(s):  
Extracellular Matrix ◽  
Mammary Gland ◽  
Matrix Metalloproteinases ◽  
Potential Role ◽  
Critical Role ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Lens Development ◽  
Cell Behaviors ◽  
Placode Formation

The formation of non-neurogenic placodes is critical prior to the development of several epithelial derivatives (e.g., feathers, teeth, etc.) and their development frequently involves morphogenetic proteins (or morphogens). Matrix metalloproteinases (MMPs) are important enzymes involved in extracellular matrix remodeling, and recent research has shown that the extracellular matrix (ECM) can modulate morphogen diffusion and cell behaviors. This review summarizes the known roles of MMPs during the development of non-neurogenic structures that involve a placodal stage. Specifically, we discuss feather, hair, tooth, mammary gland and lens development. This review highlights the potential critical role MMPs may play during placode formation in these systems.

scholarly journals Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer

2017 ◽  
Vol 77 (12) ◽  
pp. 3280-3292 ◽  
Author(s):  
Ariella B. Hanker ◽  
Mónica Valeria Estrada ◽  
Giampaolo Bianchini ◽  
Preston D. Moore ◽  
Junfei Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Integrin Signaling ◽  
Her2 Breast Cancer

Human leiomyoma cell proliferation and extracellular matrix expression is inhibited by integrin signaling

2009 ◽  
Vol 92 (3) ◽  
pp. S2 ◽  
Author(s):  
M. Malik ◽  
D. Jardine ◽  
C. Owen ◽  
D. McCarthy-Keith ◽  
J. Segars ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Integrin Signaling ◽  
Matrix Expression

scholarly journals Crim1 regulates integrin signaling in murine lens development

2016 ◽  
Vol 129 (3) ◽  
pp. e1.2-e1.2
Author(s):  
Ying Zhang ◽  
Jieqing Fan ◽  
Joshua W. K. Ho ◽  
Tommy Hu ◽  
Stephen C. Kneeland ◽  
...  
Keyword(s):  
Integrin Signaling ◽  
Lens Development

scholarly journals Extracellular matrix-inducing Sox9 orchestrates basal progenitor proliferation and gliogenesis in developing neocortex

2019 ◽  
Author(s):  
Ayse Güven ◽  
Denise Stenzel ◽  
Katherine R. Long ◽  
Marta Florio ◽  
Holger Brandl ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Fate ◽  
Subventricular Zone ◽  
Integrin Signaling ◽  
Sox9 Expression ◽  
Embryonic Mouse ◽  
Functional Studies ◽  
Basal Progenitor ◽  
Developing Neocortex ◽  
Stimulation Of

AbstractNeocortex expansion is largely based on the proliferative capacity of basal progenitors (BPs), which is increased by extracellular matrix (ECM) components via integrin signaling. Here we show that Sox9 drives expression of ECM components and that laminin 211 increases BP proliferation in embryonic mouse neocortex. Examination of Sox9 expression reveals that Sox9 is expressed in BPs of developing ferret and human, but not mouse neocortex. Functional studies by conditional Sox9 expression in the mouse BP lineage demonstrate increased BP proliferation, reduced Tbr2 and induction of Olig2 expression, indicative of premature gliogenesis. Conditional Sox9 expression also results in cell non-autonomous stimulation of BP proliferation followed by increased production of upper-layer neurons. Collectively, our findings demonstrate that Sox9 exerts concerted effects on transcription, BP proliferation, neuron production, and neurogenic as well as gliogenic BP cell fate, suggesting that Sox9 acts a master regulator in the subventricular zone to promote neocortical expansion.

scholarly journals Focal adhesion kinase signaling is decreased in polyamine-depleted IEC-6 cells

2001 ◽  
Vol 281 (2) ◽  
pp. C475-C485 ◽  
Author(s):  
Ramesh M. Ray ◽  
Mary Jane Viar ◽  
Shirley A. McCormack ◽  
Leonard R. Johnson
Keyword(s):  
Extracellular Matrix ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Focal Adhesions ◽  
Stress Fiber ◽  
Fiber Formation ◽  
Integrin Signaling ◽  
Actin Stress Fiber ◽  
Stress Fiber Formation ◽  
And Migration

Polyamines are essential to the migration of epithelial cells in the intestinal mucosa. Cells depleted of polyamines do not attach as rapidly to the extracellular matrix and do not form the actin stress fibers essential for migration. Because both attachment and stress fiber formation depend on integrin signaling and the formation of focal adhesions, we examined these and related processes in polyamine-depleted IEC-6 cells. There was general decreased tyrosine phosphorylation of focal adhesion kinase (FAK), and, specifically, decreased phosphorylation of Tyr-925, the paxillin binding site. In control cells, FAK phosphorylation was rapid after attachment to the extracellular matrix, while attached cells depleted of polyamines had significantly delayed phosphorylation. FAK activity was also significantly inhibited in polyamine-depleted cells as was the phosphorylation of paxillin. Polyamine-depleted cells failed to spread normally after attachment, and immunocytochemistry showed little colocalization of FAK and actin compared with controls. Focal adhesion complex formation was greatly reduced in the absence of polyamines. These data suggest that defective integrin signaling may, at least in part, account for the decreased rates of attachment, actin stress fiber formation, spreading, and migration observed in polyamine-depleted cells.

scholarly journals Extracellular matrix and α5β1 integrin signaling control the maintenance of bone formation capacity by human adipose-derived stromal cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Nunzia Di Maggio ◽  
Elisa Martella ◽  
Agne Frismantiene ◽  
Therese J. Resink ◽  
Simone Schreiner ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Bone Formation ◽  
Stromal Cells ◽  
Integrin Signaling ◽  
Adipose Derived Stromal Cells ◽  
Α5β1 Integrin
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