scholarly journals Cancer prevention and therapy through the modulation of the tumor microenvironment

2015 ◽  
Vol 35 ◽  
pp. S199-S223 ◽  
Author(s):  
Stephanie C. Casey ◽  
Amedeo Amedei ◽  
Katia Aquilano ◽  
Asfar S. Azmi ◽  
Fabian Benencia ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Prevention ◽  
Prevention And Therapy

scholarly journals Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

2020 ◽  
Vol 21 (2) ◽  
pp. 684 ◽  
Author(s):  
Yan Bian ◽  
Juntong Wei ◽  
Changsheng Zhao ◽  
Guorong Li
Keyword(s):  
Side Effects ◽  
Tumor Microenvironment ◽  
Cancer Prevention ◽  
Human Health ◽  
Clinical Studies ◽  
Natural Polyphenols ◽  
Therapy Strategy ◽  
Anti Cancer ◽  
Preclinical And Clinical Studies ◽  
Prevention And Therapy

Cancer is one of the most serious diseases endangering human health. In view of the side effects caused by chemotherapy and radiotherapy, it is necessary to develop low-toxic anti-cancer compounds. Polyphenols are natural compounds with anti-cancer properties and their application is a considerable choice. Pro-senescence therapy is a recently proposed anti-cancer strategy and has been shown to effectively inhibit cancer. It is of great significance to clarify the mechanisms of polyphenols on tumor suppression by inducing senescence. In this review, we delineated the characteristics of senescent cells, and summarized the mechanisms of polyphenols targeting tumor microenvironment and inducing cancer cell senescence for cancer prevention and therapy. Although many studies have shown that polyphenols effectively inhibit cancer by targeting senescence, it warrants further investigation in preclinical and clinical studies.

scholarly journals Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy

2020 ◽  
Author(s):  
Haseeb Zubair ◽  
Mohammad Aslam Khan ◽  
Shashi Anand ◽  
Sanjeev Kumar Srivastava ◽  
Seema Singh ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Prevention ◽  
Natural Agents ◽  
Prevention And Therapy

scholarly journals Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?

2021 ◽  
Vol 22 (15) ◽  
pp. 8223
Author(s):  
Violetta Krajka-Kuźniak ◽  
Wanda Baer-Dubowska
Keyword(s):  
Cancer Prevention ◽  
Signaling Pathways ◽  
Current Knowledge ◽  
Cancer Chemoprevention ◽  
Antioxidant Response ◽  
Natural Food ◽  
Related Factor ◽  
Nuclear Factor ◽  
Edible Plant ◽  
Prevention And Therapy

Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B) signaling pathways play a central role in suppressing or inducing inflammation and angiogenesis processes. Therefore, they are involved in many steps of carcinogenesis through cooperation with multiple signaling molecules and pathways. Targeting both transcription factors simultaneously may be considered an equally important strategy for cancer chemoprevention and therapy. Several hundreds of phytochemicals, mainly edible plant and vegetable components, were shown to activate Nrf2 and mediate antioxidant response. A similar number of phytochemicals was revealed to affect NF-κB. While activation of Nrf2 and inhibition of NF-κB may protect normal cells against cancer initiation and promotion, enhanced expression and activation in cancer cells may lead to resistance to conventional chemo- or radiotherapy. Most phytochemicals, through different mechanisms, activate Nrf2, but others, such as luteolin, can act as inhibitors of both Nrf2 and NF-κB. Despite many experimental data confirming the above mechanisms currently, limited evidence exists demonstrating such activity in humans. Combinations of phytochemicals resembling that in a natural food matrix but allowing higher concentrations may improve their modulating effect on Nrf2 and NF-κB and ultimately cancer prevention and therapy. This review presents the current knowledge on the effect of selected phytochemicals and their combinations on Nrf2 and NF-κB activities in the above context.

scholarly journals Lung Cancer Prevention and Therapy Using the JinFuKang Herbal Mixture

2015 ◽  
Vol 1 (5) ◽  
pp. 346-353 ◽  
Author(s):  
Lijing Jiao ◽  
Yian Wang ◽  
Ling Xu ◽  
Ming You
Keyword(s):  
Lung Cancer ◽  
Cancer Prevention ◽  
Herbal Mixture ◽  
Lung Cancer Prevention ◽  
Prevention And Therapy

scholarly journals Honokiol: A Novel Natural Agent for Cancer Prevention and Therapy

2012 ◽  
Vol 12 (10) ◽  
pp. 1244-1252 ◽  
Author(s):  
S. Arora ◽  
S. Singh ◽  
G.A. Piazza ◽  
C.M. Contreras ◽  
J. Panyam ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Natural Agent ◽  
Prevention And Therapy

Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations

2021 ◽  
pp. 105837
Author(s):  
Arijit Mondal ◽  
Sabyasachi Banerjee ◽  
Sankhadip Bose ◽  
Sujayita Mazumder ◽  
Rebecca A. Haber ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Prevention And Therapy

Breast cancer and sphingolipid signalling

2005 ◽  
Vol 72 (S1) ◽  
pp. 5-13 ◽  
Author(s):  
Paola Signorelli ◽  
Riccardo Ghidoni
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Biological Membranes ◽  
Breast Cancer Prevention ◽  
Intracellular Signalling ◽  
Regulated Functions ◽  
Tumour Initiation ◽  
Prevention And Therapy

Cancer develops from overlapping events that tend to deregulate the metabolism and unbalance the homeostasis of cells. Sphingolipids, major components of biological membranes, are also mediators of intracellular signalling. Their metabolism can be influenced by diverse stimuli and the accumulation or deficiency of intermediates may trigger proliferation and/or impair the ability of damaged cells to undergo apoptosis. Many sphingolipid-regulated functions are implicated in tumour initiation, promotion, progression and responsiveness to chemotherapy. In this review, evidence of the alteration of sphingolipids metabolism and signalling will be discussed in breast cancer prevention and therapy.

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