scholarly journals New insights into the mechanisms of organ-specific breast cancer metastasis

2012 ◽  
Vol 22 (3) ◽  
pp. 226-233 ◽  
Author(s):  
Girieca Lorusso ◽  
Curzio Rüegg
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Organ Specific

scholarly journals Reactivation of BMP signaling by suboptimal concentrations of MEK inhibitor and FK506 reduces organ-specific breast cancer metastasis

2020 ◽  
Vol 493 ◽  
pp. 41-54
Author(s):  
Jiang Ren ◽  
Yanhong Wang ◽  
Thomas Ware ◽  
Josephine Iaria ◽  
Peter ten Dijke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Mek Inhibitor ◽  
Breast Cancer Metastasis ◽  
Bmp Signaling ◽  
Organ Specific

A Methodological Approach to Unravel Organ-Specific Breast Cancer Metastasis

2012 ◽  
Vol 17 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Sébastien Nola ◽  
Soraya Sin ◽  
Florian Bonin ◽  
Rosette Lidereau ◽  
Keltouma Driouch
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Methodological Approach ◽  
Breast Cancer Metastasis ◽  
Organ Specific

scholarly journals 296P Recapitulation of organ-specific breast cancer metastasis using an engineered multi-tissue platform

2021 ◽  
Vol 32 ◽  
pp. S493-S494
Author(s):  
A. Chramiec ◽  
E. Öztürk ◽  
M. Wang ◽  
K. Ronaldson-Bouchard ◽  
D.N. Tavakol ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Organ Specific

scholarly journals Tumor-derived exosomal components: the multifaceted roles and mechanisms in breast cancer metastasis

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Yufang Tan ◽  
Xiao Luo ◽  
Wenchang Lv ◽  
Weijie Hu ◽  
Chongru Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Tumor Vascularization ◽  
Multistage Process ◽  
Organ Specific ◽  
Distant Organ ◽  
Underlying Mechanisms ◽  
Invasion Behavior ◽  
Related Mortality

AbstractBreast cancer (BC) is the most frequently invasive malignancy and the leading cause of tumor-related mortality among women worldwide. Cancer metastasis is a complex, multistage process, which eventually causes tumor cells to colonize and grow at the metastatic site. Distant organ metastases are the major obstacles to the management of advanced BC patients. Notably, exosomes are defined as specialized membrane-enclosed extracellular vesicles with specific biomarkers, which are found in a wide variety of body fluids. Recent studies have demonstrated that exosomes are essential mediators in shaping the tumor microenvironment and BC metastasis. The transferred tumor-derived exosomes modify the capability of invasive behavior and organ-specific metastasis in recipient cells. BC exosomal components, mainly including noncoding RNAs (ncRNAs), proteins, lipids, are the most investigated components in BC metastasis. In this review, we have emphasized the multifaceted roles and mechanisms of tumor-derived exosomes in BC metastasis based on these important components. The underlying mechanisms mainly include the invasion behavior change, tumor vascularization, the disruption of the vascular barrier, and the colonization of the targeted organ. Understanding the significance of tumor-derived exosomal components in BC metastasis is critical for yielding novel routes of BC intervention.

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