scholarly journals Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A 1H MRS Study at 7Tesla

2016 ◽  
Vol 172 (1-3) ◽  
pp. 101-105 ◽  
Author(s):  
Allison S. Brandt ◽  
Paul G. Unschuld ◽  
Subechhya Pradhan ◽  
Issel Anne L. Lim ◽  
Gregory Churchill ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
1H Mrs ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-Related Changes in the Functional Network Underlying Specific and General Autobiographical Memory Retrieval: A Pivotal Role for the Anterior Cingulate Cortex

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82385 ◽  
Author(s):  
Pénélope Martinelli ◽  
Marco Sperduti ◽  
Anne-Dominique Devauchelle ◽  
Sandrine Kalenzaga ◽  
Thierry Gallarda ◽  
...  
Keyword(s):  
Autobiographical Memory ◽  
Anterior Cingulate Cortex ◽  
Memory Retrieval ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Pivotal Role ◽  
Functional Network ◽  
Age Related ◽  
Age Related Changes

Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal 1H-MRS study

2021 ◽  
Vol 49 ◽  
pp. 93-100
Author(s):  
M.G. Soeiro-de-Souza ◽  
E. Scotti-Muzzi ◽  
F. Fernandes ◽  
R.T. De Sousa ◽  
C.C. Leite ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Bipolar Depression ◽  
Cingulate Cortex ◽  
Metabolic Changes ◽  
Anterior Cingulate ◽  
1H Mrs

[P1-432]: ANTERIOR CINGULATE CORTEX EXHIBITS AGE-RELATED METABOLIC CHANGES: CORRELATION WITH BEHAVIORAL PERFORMANCE IN ATTENTION TASK

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P446-P447
Author(s):  
Pui Wai Chiu ◽  
Hui Zhang ◽  
Wai Ho Savio Wong ◽  
Tianyan Liu ◽  
Gloria Hoi Yan Wong ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Metabolic Changes ◽  
Anterior Cingulate ◽  
Behavioral Performance ◽  
Attention Task ◽  
Age Related

scholarly journals Aging-Related Hypometabolism in the Anterior Cingulate Cortex of Cognitively Intact, Amyloid-Negative Seniors at Rest Mediates the Relationship between Age and Executive Function but Not Memory

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
José V Pardo ◽  
Shantal M Nyabwari ◽  
Joel T Lee ◽  
Keyword(s):  
Executive Function ◽  
Anterior Cingulate Cortex ◽  
Cognitive Aging ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Metabolic Dysfunction ◽  
Age Related ◽  
Regional Specificity ◽  
Cognitively Intact ◽  
The Relationship

Abstract The anterior cingulate cortex (ACC) shows the most aging-related brain metabolic dysfunction that correlates with decreasing executive processing in otherwise healthy, cognitively intact volunteers. Here, data from ADNI are used to elucidate potential pathophysiological mechanisms involved in cognitive aging, that is, age-related decline in cognitive performance in the absence of known neurodegenerative disease. Amyloid-negative volunteers showed statistically significant mediation of ACC metabolism in the relationship between age and verbal fluency. A nonlinguistic task of executive function, Trails B, showed also negative correlation between performance and age, albeit weaker, but was not significant in the mediation analysis. Recall of story items, minimizing attentional demands compared with learning of word lists, did not correlate with age. ADNI subjects selected for low vascular risks also showed correlation between age and declining ACC metabolism. In the whole-brain amyloid-negative subset, ACC amyloid was not correlated with age. As expected, the metabolism in an arbitrary region such as motor cortex that was not expected to decline with cognitive aging showed no correlation with age or ACC metabolism suggesting regional specificity. These findings motivate the search for the pathophysiology of aging-related ACC dysfunction to prevent, diagnose, and treat the decline in executive function associated with cognitive aging.

scholarly journals Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse

2021 ◽  
Author(s):  
Kelly Perlman ◽  
Raphael Chouinard-Watkins ◽  
Arnaud Tanti ◽  
Giulia Cisbani ◽  
Massimiliano Orri ◽  
...  
Keyword(s):  
Child Abuse ◽  
White Matter ◽  
Anterior Cingulate Cortex ◽  
Methyl Esters ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Sequencing Data ◽  
Early Life Adversity ◽  
Age Related ◽  
History Of

Child abuse (CA) strongly increases the lifetime risk of suffering from major depression and predicts an unfavorable course for the illness. Severe CA has been associated with a specific dysregulation of oligodendrocyte function and thinner myelin sheaths in the human anterior cingulate cortex (ACC) white matter. Given that myelin is extremely lipid-rich, it is plausible that these findings may be accompanied by a disruption of the lipid profile that composes the myelin sheath. This is important to explore since the composition of fatty acids (FA) in myelin phospholipids can influence its stability, permeability, and compactness. Therefore, the objective of this study was to quantify and compare FA concentrations in postmortem ACC white matter in the choline glycerophospholipid pool (ChoGpl), a key myelin phospholipid pool, between adult depressed suicides with a history of CA (DS-CA) matched depressed suicides without CA (DS) and healthy non-psychiatric controls (CTRL). Total lipids were extracted according to the Folch method and separated into respective classes using thin-layer chromatography. FA methyl esters from the ChoGpl fraction were quantified using gas chromatography. Our analysis revealed a strong age-related decrease in most FAs, and specific effects of CA in FAs from the arachidonic acid synthesis pathway, which was further validated with RNA-sequencing data. Furthermore, the concentration of most FAs was found to decrease with age. By extending the previous molecular level findings linking CA with altered myelination in the ACC, these results provide further insights regarding white matter alterations associated with early-life adversity.

scholarly journals Altered Developmental Trajectories in Intrinsic Function between Default, Salience, and Executive Networks in High-Functioning Autism

2018 ◽  
Author(s):  
Liu Yang ◽  
Xiao Chen ◽  
Xue Li ◽  
Yang-Qian Shen ◽  
Hui Wang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Developmental Trajectories ◽  
Cingulate Cortex ◽  
Autism Spectrum ◽  
Developmental Trajectory ◽  
Anterior Cingulate ◽  
Ventral Medial Prefrontal Cortex ◽  
Age Related ◽  
Brain Functional Connectivity ◽  
Age Related Changes

AbstractAlthough many studies have focused on abnormal patterns of brain functional connectivity in Autism spectrum disorder (ASD), one important factor, the developmental effect of brain networks was largely overlooked. To clarify the abnormal developmental trajectory of brain functional connectivity in ASD, we focused on the age-related changes in three “core” neurocognitive networks: default mode network (DMN), salience network (SN) and central executive network (CEN, also divided into left and right CEN, i.e., lCEN and rCEN). The development of intrinsic functional connectivity (iFC) within and between these networks were analyzed in 107 Chinese participants, including children, adolescents, and adults (54 patients with ASD and 53 typically developed (TD) participants; ages 6-30 years). We found that diagnosis-related distinctions in age-related changes suggest three maturation patterns in networks’ or nodes’ iFC: delayed (iFC between SN and rCEN), ectopic (iFC between SN and DMN, and iFC between posterior cingulate cortex (PCC) and right anterior insula/dorsal anterior cingulate cortex (dACC)), and failure maturation (iFC between dACC and ventral medial prefrontal cortex). Compared with age-matched TD participants, ASD patients in children and adolescents exhibited hypo-connectivity, while that in adults showed hyper-connectivity. In addition, an independent verification based on Autism Brain Imaging Data Exchange (ABIDE) datasets confirmed our findings of developmental trajectories in ASD group, which also showed unchanged functional connectivity with age between DMN and SN and increasing iFC between rCEN and SN. The conspicuous differences in the development of three “core” networks in ASD were demonstrated, which may lead a nuanced understanding towards the abnormal brain network maturation trajectory of autism.

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