scholarly journals Changes in carotid body and nTS neuronal excitability following neonatal sustained and chronic intermittent hypoxia exposure

2015 ◽  
Vol 205 ◽  
pp. 28-36 ◽  
Author(s):  
C.A. Mayer ◽  
C.G. Wilson ◽  
P.M. MacFarlane
Keyword(s):  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Neuronal Excitability ◽  
Chronic Intermittent Hypoxia ◽  
Hypoxia Exposure

scholarly journals NADPH Oxidase Is Required for the Sensory Plasticity of the Carotid Body by Chronic Intermittent Hypoxia

2009 ◽  
Vol 29 (15) ◽  
pp. 4903-4910 ◽  
Author(s):  
Y.- J. Peng ◽  
J. Nanduri ◽  
G. Yuan ◽  
N. Wang ◽  
E. Deneris ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Sensory Plasticity

scholarly journals Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia

2016 ◽  
Vol 120 (8) ◽  
pp. 982-990 ◽  
Author(s):  
Peiying Pai ◽  
Ching Jung Lai ◽  
Ching-Yuang Lin ◽  
Yi-Fan Liou ◽  
Chih-Yang Huang ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Superoxide Anion ◽  
Intermittent Hypoxia ◽  
Caspase 3 ◽  
Fas Ligand ◽  
Left Ventricular ◽  
Chronic Intermittent Hypoxia ◽  
Apoptotic Pathway ◽  
Hypoxia Exposure ◽  
Survival Pathway

Only very limited information regarding the protective effects of the superoxide anion scavenger on chronic intermittent hypoxia-induced cardiac apoptosis is available. The purpose of this study is to evaluate the effects of the superoxide anion scavenger on cardiac apoptotic and prosurvival pathways in rats with sleep apnea. Forty-two Sprague-Dawley rats were divided into three groups, rats with normoxic exposure (Control, 21% O2, 1 mo), rats with chronic intermittent hypoxia exposure (Hypoxia, 3-7% O2 vs. 21% O2 per 40 s cycle, 8 h per day, 1 mo), and rats with pretreatment of the superoxide anion scavenger and chronic intermittent hypoxia exposure (Hypoxia-O2−-Scavenger, MnTMPyP pentachloride, 1 mg/kg ip per day; 3–7% O2 vs. 21% O2 per 40 s cycle, 8 h per day, 1 mo) at 5–6 mo of age. After 1 mo, the protein levels and apoptotic cells of excised hearts from three groups were measured by Western blotting and terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assay. The superoxide anion scavenger decreased hypoxia-induced myocardial architecture abnormalities, left ventricular hypertrophy, and TUNEL-positive apoptosis. The superoxide anion scavenger decreased hypoxia-induced Fas ligand, Fas death receptors, Fas-associated death domain (FADD), activated caspase-8, and activated caspase-3 (Fas-dependent apoptotic pathway) as well as Bad, activated caspase-9 and activated caspase-3 (mitochondria-dependent apoptotic pathway), endonuclease G (EndoG), apoptosis-inducing factor (AIF), and TUNEL-positive apoptosis. The superoxide anion scavenger increased IGF-1, IGF-1R, p-PI3k, p-Akt, p-Bad, Bcl-2, and Bcl-xL (survival pathway). Our findings imply that the superoxide anion scavenger might prevent cardiac Fas-mediated and mitochondrial-mediated apoptosis and enhance the IGF-1-related survival pathway in chronic intermittent hypoxia. The superoxide anion scavenger may prevent chronic sleep apnea-enhanced cardiac apoptotic pathways and enhances cardiac survival pathways.

Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity

2004 ◽  
Vol 96 (3) ◽  
pp. 1236-1242 ◽  
Author(s):  
Ying-Jie Peng ◽  
Nanduri R. Prabhakar
Keyword(s):  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Ex Vivo ◽  
Previous Treatment ◽  
Male Rats ◽  
Sensory Response ◽  
Chronic Intermittent Hypoxia ◽  
Radical Scavenger ◽  
Sprague Dawley ◽  
Carotid Bodies

Reflexes arising from the carotid bodies may play an important role in cardiorespiratory changes evoked by chronic intermittent hypoxia (CIH). In the present study, we examined whether CIH affects the hypoxic sensing ability of the carotid bodies and, if so, by what mechanisms. Experiments were performed on adult male rats (Sprague-Dawley, 250–300 g) exposed to two paradigms of CIH for 10 days: 1) multiple exposures to short durations of intermittent hypoxia per day (SDIH; 15sof5%O2 + 5 min of 21% O2, 9 episodes/h, 8 h/day) and 2) single exposure to longer durations of intermittent hypoxia per day [LDIH; 4 h of hypobaric hypoxia (0.4 atm/day) + 20 h of normoxia]. Carotid body sensory response to graded isocapnic hypoxia was examined in both groups of animals under anesthetized conditions. Hypoxic sensory response was significantly enhanced in SDIH but not in LDIH animals. Similar enhancement in hypoxic sensory response was also elicited in ex vivo carotid bodies from SDIH animals, suggesting that the effects were not secondary to cardiovascular changes. SDIH, however, had no significant effect on the hypercapnic sensory response. The effects of SDIH on the hypoxic sensory response completely reversed after SDIH animals were placed in a normoxic environment for an additional 10 days. Previous treatment with systemic administration of [Formula: see text] radical scavenger prevented SDIH-induced augmentation of the hypoxic sensory response. These results demonstrate that SDIH but not LDIH results in selective augmentation of the hypoxic response of the carotid body and [Formula: see text] radicals play an important role in SDIH-induced sensitization of the carotid body.

scholarly journals Maladaptive Pulmonary Vascular Responses to Chronic Sustained and Chronic Intermittent Hypoxia in Rat

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 54
Author(s):  
Jesus Prieto-Lloret ◽  
Elena Olea ◽  
Ana Gordillo-Cano ◽  
Inmaculada Docio ◽  
Ana Obeso ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Carotid Body ◽  
Pulmonary Circulation ◽  
Intermittent Hypoxia ◽  
Pulmonary Arteries ◽  
Systemic Circulation ◽  
Systemic Hypertension ◽  
Chronic Intermittent Hypoxia ◽  
Respiratory Disorder ◽  
Obstructive Sleep

Chronic sustained hypoxia (CSH), as found in individuals living at a high altitude or in patients suffering respiratory disorders, initiates physiological adaptations such as carotid body stimulation to maintain oxygen levels, but has deleterious effects such as pulmonary hypertension (PH). Obstructive sleep apnea (OSA), a respiratory disorder of increasing prevalence, is characterized by a situation of chronic intermittent hypoxia (CIH). OSA is associated with the development of systemic hypertension and cardiovascular pathologies, due to carotid body and sympathetic overactivation. There is growing evidence that CIH can also compromise the pulmonary circulation, causing pulmonary hypertension in OSA patients and animal models. The aim of this work was to compare hemodynamics, vascular contractility, and L-arginine-NO metabolism in two models of PH in rats, associated with CSH and CIH exposure. We demonstrate that whereas CSH and CIH cause several common effects such as an increased hematocrit, weight loss, and an increase in pulmonary artery pressure (PAP), compared to CIH, CSH seems to have more of an effect on the pulmonary circulation, whereas the effects of CIH are apparently more targeted on the systemic circulation. The results suggest that the endothelial dysfunction evident in pulmonary arteries with both hypoxia protocols are not due to an increase in methylated arginines in these arteries, although an increase in plasma SDMA could contribute to the apparent loss of basal NO-dependent vasodilation and, therefore, the increase in PAP that results from CIH.

scholarly journals NEUROGLOBIN, A NEW OXYGEN BINDING PROTEIN IS PRESENT IN THE CAROTID BODY AND INCREASES AFTER CHRONIC INTERMITTENT HYPOXIA.

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Di Giulio Camillo ◽  
Cacchio Marisa ◽  
Amicarelli Fernanda ◽  
Di Ilio Carmine ◽  
Iturriaga Rodrigo
Keyword(s):  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Binding Protein ◽  
Chronic Intermittent Hypoxia ◽  
Oxygen Binding
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