Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia

2019 ◽  
Vol 234 (8) ◽  
pp. 13534-13543 ◽  
Author(s):  
Pei Liu ◽  
Hong‐Mei Zhang ◽  
Ke Hu ◽  
Xiu‐Fang Zhou ◽  
Si Tang
Keyword(s):  
Oxidative Stress ◽  
Paraventricular Nucleus ◽  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Sensory Plasticity

scholarly journals NADPH Oxidase Is Required for the Sensory Plasticity of the Carotid Body by Chronic Intermittent Hypoxia

2009 ◽  
Vol 29 (15) ◽  
pp. 4903-4910 ◽  
Author(s):  
Y.- J. Peng ◽  
J. Nanduri ◽  
G. Yuan ◽  
N. Wang ◽  
E. Deneris ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Sensory Plasticity

scholarly journals Nitration of MnSOD in the Carotid Body and Adrenal Gland Induced by Chronic Intermittent Hypoxia

2018 ◽  
Vol 66 (10) ◽  
pp. 753-765
Author(s):  
Esteban A. Moya ◽  
Paulina Arias ◽  
Rodrigo Iturriaga
Keyword(s):  
Oxidative Stress ◽  
Adrenal Gland ◽  
Enzymatic Activity ◽  
Adrenal Medulla ◽  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Sprague Dawley ◽  
Obstructive Sleep ◽  
Key Enzyme

Chronic intermittent hypoxia (CIH), main feature of obstructive sleep apnea, produces nitro-oxidative stress, which contributes to potentiate carotid body (CB) chemosensory discharges and sympathetic-adrenal-axis activity, leading to hypertension. The MnSOD enzymatic activity, a key enzyme on oxidative stress control, is reduced by superoxide-induced nitration. However, the effects of CIH-induced nitration on MnSOD enzymatic activity in the CB and adrenal gland are not known. We studied the effects of CIH on MnSOD protein and immunoreactive (MnSOD-ir) levels in the CB, adrenal gland and superior cervical ganglion (SCG), and on 3-nitrotyrosine (3-NT-ir), CuZnSOD (CuZnSOD-ir), MnSOD nitration, and its enzymatic activity in the CB and adrenal gland from male Sprague-Dawley rats exposed to CIH for 7 days. CIH increased 3-NT-ir in CB and adrenal gland, whereas MnSOD-ir increased in the CB and in adrenal cortex, but not in the whole adrenal medulla or SCG. CIH nitrated MnSOD in the CB and adrenal medulla, but its activity decreased in the adrenal gland. CuZnSOD-ir remained unchanged in both tissues. All changes observed were prevented by ascorbic acid treatment. Present results show that CIH for 7 days produced MnSOD nitration, but failed to reduce its activity in the CB, because of the increased protein level.

Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment

2011 ◽  
Vol 301 (5) ◽  
pp. L702-L711 ◽  
Author(s):  
Rodrigo Del Rio ◽  
Cristian Muñoz ◽  
Paulina Arias ◽  
Felipe A. Court ◽  
Esteban A. Moya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Vessel Diameter ◽  
Chronic Intermittent Hypoxia ◽  
Sprague Dawley ◽  
Antioxidant Treatment ◽  
Sprague Dawley Rats ◽  
Vascular Area

Chronic intermittent hypoxia (CIH), a characteristic of sleep obstructive apnea, enhances carotid body (CB) chemosensory responses to hypoxia, but its consequences on CB vascular area and VEGF expression are unknown. Accordingly, we studied the effect of CIH on CB volume, glomus cell numbers, blood vessel diameter and number, and VEGF immunoreactivity (VEGF-ir) in male Sprague-Dawley rats exposed to 5% O2, 12 times/h for 8 h or sham condition for 21 days. We found that CIH did not modify the CB volume or the number of glomus cells but increased VEGF-ir and enlarged the vascular area by increasing the size of the blood vessels, whereas the number of the vessels was unchanged. Because oxidative stress plays an essential role in the CIH-induced carotid chemosensory potentiation, we tested whether antioxidant treatment with ascorbic acid may impede the vascular enlargement and the VEGF upregulation. Ascorbic acid, which prevents the CB chemosensory potentiation, failed to impede the vascular enlargement and the increased VEGF-ir. Thus present results suggest that the CB vascular enlargement induced by CIH is a direct effect of intermittent hypoxia and not secondary to the oxidative stress. Accordingly, the subsequent capillary changes may be secondary to the mechanisms involved in the neural chemosensory plasticity induced by intermittent hypoxia.

scholarly journals Chronic intermittent hypoxia induces hypoxic sensitivity in adult rat adrenal medulla via oxidative stress

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Ganesh K Kumar ◽  
Vandana Rai ◽  
Suresh Sharma ◽  
DeviPrasadh Ramakrishnan ◽  
Ying‐Jie Peng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adrenal Medulla ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Adult Rat

Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress

2018 ◽  
Vol 143 ◽  
pp. 225-233 ◽  
Author(s):  
Wenya Li ◽  
Shengchang Yang ◽  
Fu-Yang Yu ◽  
Yashuo Zhao ◽  
Zhi-Min Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intermittent Hypoxia ◽  
Neurocognitive Impairment ◽  
Chronic Intermittent Hypoxia
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