scholarly journals The methyl donor S -adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease

Redox Biology ◽  
2016 ◽  
Vol 9 ◽  
pp. 188-197 ◽  
Author(s):  
Adrienne L. King ◽  
Sudheer K. Mantena ◽  
Kelly K. Andringa ◽  
Telisha Millender-Swain ◽  
Kimberly J. Dunham-Snary ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Methyl Donor

scholarly journals Rosiglitazone and bezafibrate modulate gene expression in a rat model of non-alcoholic fatty liver disease - A historical prospective

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Hemda Schmilovitz-Weiss ◽  
Edith Hochhauser ◽  
Michal Cohen ◽  
Yelena Chepurko ◽  
Smadar Yitzhaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Disease ◽  
Fatty Liver ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Fish Oil Feeding Modulates the Expression of Hepatic MicroRNAs in a Western-Style Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Hualin Wang ◽  
Yang Shao ◽  
Fahu Yuan ◽  
Han Feng ◽  
Na Li ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fish Oil ◽  
Nonalcoholic Fatty Liver Disease ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Differentially Expressed ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Expression ◽  
Fish Oil Supplementation

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide. Recent studies have indicated that fish oil supplementation has benefits against NAFLD. Our previous transcriptomic study has validated the effect of fish oil supplementation on altering hepatic gene expression in a NAFLD rat model. In the current study, we examined the effects of fish oil on the expression of hepatic microRNAs. Male Sprague–Dawley rats were fed with a lab chow (CON), high-fat high-cholesterol diet (WD), or WD supplemented with fish oil (FOH), respectively. Small RNAs were extracted from livers for RNA-sequencing. A total of 79 miRNAs were identified as differentially expressed miRNAs (DEMs) between FOH and WD groups, exemplified by rno-miR-29c-3p, rno-miR-30d-5p, rno-miR-33-5p, rno-miR-34a, and rno-miR-328a-3p. Functional annotation of DEMs predicted target genes suggested that the altered hepatic miRNAs contributed to fish oil modification of hepatic lipid metabolism and signaling transduction. Integrative analysis of DEMs and differentially expressed genes suggested that the expression difference of Pcsk9, Insig2, Per3, and Socs1/3 between FOH and WD groups may be due to miRNA modification. Our study reveals that fish oil supplementation alters hepatic expression of miRNAs, which may contribute to fish oil amelioration of NAFLD in rats.

PP129-MON CITRULLINE MODULATES LIPID METABOLISM IN A RAT MODEL OF FRUCTOSE-INDUCED NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

2013 ◽  
Vol 32 ◽  
pp. S170
Author(s):  
P. Jegatheesan ◽  
S. Beutheu ◽  
G. Ventura ◽  
A.-J. Waligora-Dupriet ◽  
N. Kapel ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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