The effects of hydroalcoholic extract of spinach on prevention and treatment of some metabolic and histologic features in a rat model of nonalcoholic fatty liver disease

2020 ◽  
Vol 100 (4) ◽  
pp. 1787-1796 ◽  
Author(s):  
Ali Amirinejad ◽  
Azita Hekmatdoost ◽  
Abdolali Ebrahimi ◽  
Fatemeh Ranjbaran ◽  
Farzad Shidfar
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Hydroalcoholic Extract ◽  
Nonalcoholic Fatty Liver ◽  
Prevention And Treatment

Potential Natural Compounds for the Prevention and Treatment of Nonalcoholic Fatty Liver Disease: A Review on Molecular Mechanisms

2021 ◽  
Vol 15 ◽  
Author(s):  
Cheng Ma ◽  
Cheng Wang ◽  
Yafang Zhang ◽  
Honglin Zhou ◽  
Yunxia Li
Keyword(s):  
Liver Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Molecular Mechanisms ◽  
Natural Compounds ◽  
Nonalcoholic Fatty Liver ◽  
Prevention And Treatment

Background: Nonalcoholic fatty liver disease (NAFLD) is a kind of metabolic stress-induced liver injury closely related to insulin resistance and genetic susceptibility, and there is no specific drug for its clinical treatment currently. In recent years, a large amount of literature has reported that many natural compounds extracted from traditional Chinese medicine (TCM) can improve NAFLD through various mechanisms. According to the latest reports, some emerging natural compounds have shown great potential to improve NAFLD but are seldom used clinically due to the lacking special research. Purpose: This paper aims to summarize the molecular mechanisms of the potential natural compounds on improving NAFLD, thus providing a direction and basis for further research on the pathogenesis of NAFLD and the development of effective drugs for the prevention and treatment of NAFLD. Methods: By searching various online databases, such as Web of Science, SciFinder, PubMed, and CNKI, NAFLD and these natural compounds were used as the keywords for detailed literature retrieval. Results: The pathogenesis of NAFLD and the molecular mechanisms of the potential natural compounds on improving NAFLD have been reviewed. Conclusion: Many natural compounds from traditional Chinese medicine have a good prospect in the treatment of NAFLD, which can serve as a direction for the development of anti-NAFLD drugs in the future.

scholarly journals Fish Oil Feeding Modulates the Expression of Hepatic MicroRNAs in a Western-Style Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Hualin Wang ◽  
Yang Shao ◽  
Fahu Yuan ◽  
Han Feng ◽  
Na Li ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fish Oil ◽  
Nonalcoholic Fatty Liver Disease ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Differentially Expressed ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Expression ◽  
Fish Oil Supplementation

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide. Recent studies have indicated that fish oil supplementation has benefits against NAFLD. Our previous transcriptomic study has validated the effect of fish oil supplementation on altering hepatic gene expression in a NAFLD rat model. In the current study, we examined the effects of fish oil on the expression of hepatic microRNAs. Male Sprague–Dawley rats were fed with a lab chow (CON), high-fat high-cholesterol diet (WD), or WD supplemented with fish oil (FOH), respectively. Small RNAs were extracted from livers for RNA-sequencing. A total of 79 miRNAs were identified as differentially expressed miRNAs (DEMs) between FOH and WD groups, exemplified by rno-miR-29c-3p, rno-miR-30d-5p, rno-miR-33-5p, rno-miR-34a, and rno-miR-328a-3p. Functional annotation of DEMs predicted target genes suggested that the altered hepatic miRNAs contributed to fish oil modification of hepatic lipid metabolism and signaling transduction. Integrative analysis of DEMs and differentially expressed genes suggested that the expression difference of Pcsk9, Insig2, Per3, and Socs1/3 between FOH and WD groups may be due to miRNA modification. Our study reveals that fish oil supplementation alters hepatic expression of miRNAs, which may contribute to fish oil amelioration of NAFLD in rats.

Soy β-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease

2015 ◽  
Vol 9 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Satoshi Wanezaki ◽  
Nobuhiko Tachibana ◽  
Mayuko Nagata ◽  
Shintaro Saito ◽  
Koji Nagao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Metabolic Abnormalities ◽  
Nonalcoholic Fatty Liver

Hepatoprotective Effect of Tricholoma giganteum (Agaricomycetes) in a Nonalcoholic Fatty Liver Disease Rat Model

2016 ◽  
Vol 18 (8) ◽  
pp. 661-669
Author(s):  
Ramar Govindaraj ◽  
Michael Gabriel Paulraj ◽  
Erenius Toppo ◽  
Perumal Pandikumar ◽  
Savarimuthu Ignacimuthu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Hepatoprotective Effect ◽  
Nonalcoholic Fatty Liver

Effects of Sleeve Gastrectomy on Nonalcoholic Fatty Liver Disease in an Obese Rat Model

2017 ◽  
Vol 28 (6) ◽  
pp. 1532-1539 ◽  
Author(s):  
Kiminori Watanabe ◽  
Masayuki Ohta ◽  
Hiroomi Takayama ◽  
Kazuhiro Tada ◽  
Yuki Shitomi ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver
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