Regulating the anticancer drug release rate by controlling the composition of waterborne polyurethane

2018 ◽  
Vol 131 ◽  
pp. 134-141 ◽  
Author(s):  
Ali Bahadur ◽  
Muhammad Shoaib ◽  
Shahid Iqbal ◽  
Aamer Saeed ◽  
Muhamad Saif ur Rahman ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Release Rate ◽  
Waterborne Polyurethane ◽  
Drug Release Rate

The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles

2015 ◽  
Vol 51 (64) ◽  
pp. 12835-12838 ◽  
Author(s):  
Yoshikazu Ikuta ◽  
Yoshitaka Koseki ◽  
Tsunenobu Onodera ◽  
Hidetoshi Oikawa ◽  
Hitoshi Kasai
Keyword(s):  
Molecular Structure ◽  
Controlled Release ◽  
Drug Release ◽  
Anticancer Drug ◽  
Release Rate ◽  
Chemical Structure ◽  
Anticancer Agent ◽  
Drug Release Rate ◽  
Drug Nanoparticles

The controlled release of an anticancer agent from drug nanoparticles could be successfully achieved by optimizing the chemical structure of dimeric compounds as prodrug.

Microorganism-based monodisperse microcapsules: encapsulation of the fungicide tebuconazole and its controlled release properties

RSC Advances ◽  
2015 ◽  
Vol 5 (32) ◽  
pp. 25164-25170 ◽  
Author(s):  
Bo Zhang ◽  
Teng Zhang ◽  
Quanxi Wang ◽  
Tianrui Ren
Keyword(s):  
Controlled Release ◽  
Powdery Mildew ◽  
Drug Release ◽  
Release Rate ◽  
Drug Release Rate ◽  
Burst Effect ◽  
Initial Burst ◽  
Release System ◽  
Controlled Release System ◽  
Monodisperse Microcapsules

A controlled release system was prepared, it based on UF modified PCC cells in which TEB are loaded into cells. It can control the drug release rate, depress the initial “burst effect”, and was efficacious in controlling wheat powdery mildew.

Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: Influence of PEG coating on the particle size, drug release rate and phagocytic uptake

Biomaterials ◽  
2001 ◽  
Vol 22 (21) ◽  
pp. 2857-2865 ◽  
Author(s):  
Giacomo Fontana ◽  
Mariano Licciardi ◽  
Silvana Mansueto ◽  
Domenico Schillaci ◽  
Gaetano Giammona
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Release Rate ◽  
Drug Release Rate ◽  
Peg Coating ◽  
Phagocytic Uptake

scholarly journals Dynamic crosslinked and injectable biohydrogels as extracellular matrix mimics for the delivery of antibiotics and 3D cell culture

RSC Advances ◽  
2020 ◽  
Vol 10 (33) ◽  
pp. 19587-19599 ◽  
Author(s):  
Zhiping Fan ◽  
Ping Cheng ◽  
Min Liu ◽  
Sangeeta Prakash ◽  
Jun Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Culture ◽  
Extracellular Matrix ◽  
Drug Release ◽  
Release Rate ◽  
3D Cell Culture ◽  
Drug Release Rate ◽  
Sustained Drug Delivery ◽  
Cell Scaffold ◽  
Potential Applications

Polysaccharides-polypeptide derived biohydrogels were formed using hydrazone chemistry as crosslinking strategy, which have controllable drug release rate and many other potential applications, especially in sustained drug delivery and cell scaffold.

scholarly journals FORMULATION AND EVALUATION OF LIDOCAINE HYDROCHLORIDE CHEWABLE TABLET

2018 ◽  
Vol 11 (11) ◽  
pp. 190
Author(s):  
Harshada Anil Kasar ◽  
Asish Dev ◽  
Subhakanta Dhal
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Release Rate ◽  
Statistical Models ◽  
Drug Dissolution ◽  
Lidocaine Hydrochloride ◽  
Dissolution Profile ◽  
Stability Studies ◽  
Drug Release Rate ◽  
Chewable Tablets

Objective: The objective of this study was to formulate and optimize a chewable formulation of lidocaine hydrochloride using a 32 factorial design for optimized the superdisintegrant concentration.Methods: Various concentrations of sodium starch glycolate (SSG) (13.33 mg, 26.66 mg, and 40 mg) of superdisintegrant and starch (50 mg, 83 mg, and 116.66 mg) were added in the formulation; nine formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. The models were tested for significance. Procedure to manufacture chewable tablets by direct compression was established.Results: The results show that the presence of a superdisintegrant is desirable for chewable formulation. The best-optimized batch F7 found the batch having starch of amount 116.66 mg and SSG 13.33 mg. All the prepared batches of tablets were within the range. Optimized batch F7 showed drug content 102.46±0.0543, wetting time 18±1.7320, friability 0.65±0.0216, and drug release rate 99.97±0.0124% at the end of 30 min.Conclusion: It can be concluded that 32 full factorial design and statistical models can be successfully used to optimize the formulations, and it was concluded that the trial batch F7 is the optimized formulation which compiles official specifications of chewable tablets. The optimized batch was evaluated for thickness, weight variation, hardness, friability, drug dissolution, and stability study for 3 months. The similarity factor was calculated for comparison of dissolution profile before and after stability studies. After 30 min the drug release rate for batch F7 was 98.97% (Table 6). Hence, the results of stability studies reveal that the developed formulation has good stability.

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