Synthesis, self-assembly and pH sensitivity of PDEAEMA–PEG–PDEAEMA triblock copolymer micelles for drug delivery

2016 ◽  
Vol 107 ◽  
pp. 1-10 ◽  
Author(s):  
Guiyou Wang ◽  
Lingmei Zhang
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Triblock Copolymer ◽  
Ph Sensitivity ◽  
Copolymer Micelles

Effect of Tyrosine-Derived Triblock Copolymer Compositions on Nanosphere Self-Assembly and Drug Delivery

2007 ◽  
Vol 8 (3) ◽  
pp. 998-1003 ◽  
Author(s):  
Larisa Sheihet ◽  
Karolina Piotrowska ◽  
Robert A. Dubin ◽  
Joachim Kohn ◽  
David Devore
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Triblock Copolymer

scholarly journals AIE-Based Fluorescent Triblock Copolymer Micelles for Simultaneous Drug Delivery and Intracellular Imaging

2021 ◽  
Author(s):  
Bhagyashree Kulkarni ◽  
Somayah Qutub ◽  
Viko Ladelta ◽  
Niveen M. Khashab ◽  
Nikos Hadjichristidis
Keyword(s):  
Drug Delivery ◽  
Triblock Copolymer ◽  
Intracellular Imaging ◽  
Copolymer Micelles

Biamphiphilic triblock copolymer micelles as a multifunctional platform for anticancer drug delivery

2010 ◽  
Vol 96A (2) ◽  
pp. 330-340 ◽  
Author(s):  
Wen Zhu ◽  
YanLi Li ◽  
LiXin Liu ◽  
WenLong Zhang ◽  
YongMing Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Triblock Copolymer ◽  
Anticancer Drug Delivery ◽  
Copolymer Micelles ◽  
Multifunctional Platform

Self-Assembly of Colloidal Quantum Dots on the Scaffold of Triblock Copolymer Micelles

2010 ◽  
Vol 2 (11) ◽  
pp. 3160-3169 ◽  
Author(s):  
Mingfeng Wang ◽  
Meng Zhang ◽  
James Li ◽  
Sandeep Kumar ◽  
Gilbert C. Walker ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Self Assembly ◽  
Triblock Copolymer ◽  
Colloidal Quantum Dots ◽  
Copolymer Micelles

Direct Imaging of Non-Classical Triblock Copolymer Blend and Gel Morphologies in the Dilute Regime

1996 ◽  
Vol 54 ◽  
pp. 188-189
Author(s):  
Jonathan H. Laurer ◽  
Richard J. Spontak ◽  
Steven D. Smith ◽  
Rudy Bukovnik
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Triblock Copolymer ◽  
Morphological Changes ◽  
Low Molecular Weight ◽  
Conformationally Constrained ◽  
Morphological Studies ◽  
Homopolymer Blends ◽  
Copolymer Blend ◽  
Copolymer Micelles

Incorporation of a low-molecular-weight, midblock-selective homopolymer into the microstructure of a microphase-ordered triblock copolymer results in preferential midblock swelling or a morphological transition, depending on the blend concentration and the size of the homopolymer chain relative to that of the host block. Since the blend properties are strongly dependent on the existing microstructure, morphological changes induced by variation in blend composition have attracted considerable interest. Recent efforts have sought to discern the phase stability of both copolymer-rich (concentrated) blends, in which parent homopolymer molecules are contained within their preferred microphase, and homo-polymer-rich (dilute) blends, in which the copolymer molecules micellize to reduce repulsive interactions in a parent homopolymer matrix. Since dilute blends typically consist of spherical copolymer micelles, most morphological studies have focused on concentrated copolymer/homopolymer blends in order to (i) tailor the blend microstructure, and properties, at the molecular level and (ii) examine macromolecular mixing in conformationally constrained nanoscale environments. In this work, we return to the dilute copolymer/homopolymer blend regime and examine the self-assembly of triblock copolymer molecules in the presence of low-molecular-weight parent and nonparent homopolymers and, in some cases, an oil.

scholarly journals A unique amphiphilic triblock copolymer, nontoxic to human blood and potential supramolecular drug delivery system for dexamethasone

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Irrum Mushtaq ◽  
Zareen Akhter ◽  
Muhammad Farooq ◽  
Farukh Jabeen ◽  
Ashfaq Ur Rehman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Human Blood ◽  
Self Assembly ◽  
Blood Cells ◽  
Triblock Copolymer ◽  
Computational Analysis ◽  
Amphiphilic Triblock Copolymer ◽  
Human Blood Cells

AbstractThe drug delivery system (DDS) often causes toxicity, triggering undesired cellular injuries. Thus, developing supramolecules used as DDS with tunable self-assembly and nontoxic behavior is highly desired. To address this, we aimed to develop a tunable amphiphilic ABA-type triblock copolymer that is nontoxic to human blood cells but also capable of self-assembling, binding and releasing the clinically used drug dexamethasone. We synthesized an ABA-type amphiphilic triblock copolymer (P2L) by incorporating tetra(aniline) TANI as a hydrophobic and redox active segment along with monomethoxy end-capped polyethylene glycol (mPEG2k; Mw = 2000 g mol−1) as biocompatible, flexible and hydrophilic part. Cell cytotoxicity was measured in whole human blood in vitro and lung cancer cells. Polymer-drug interactions were investigated by UV–Vis spectroscopy and computational analysis. Our synthesized copolymer P2L exhibited tuned self-assembly behavior with and without external stimuli and showed no toxicity in human blood samples. Computational analysis showed that P2L can encapsulate the clinically used drug dexamethasone and that drug uptake or release can also be triggered under oxidation or low pH conditions. In conclusion, copolymer P2L is nontoxic to human blood cells with the potential to carry and release anticancer/anti-inflammatory drug dexamethasone. These findings may open up further investigations into implantable drug delivery systems/devices with precise drug administration and controlled release at specific locations.

Sign in / Sign up

Export Citation Format

Share Document