PEG-b -Pt BA-b -PHEMA well-defined amphiphilic triblock copolymer: Synthesis, self-assembly, and application in drug delivery

2012 ◽  
Vol 50 (21) ◽  
pp. 4579-4588 ◽  
Author(s):  
Li Yuan ◽  
Wulian Chen ◽  
Jing Li ◽  
Jianhua Hu ◽  
Jianjun Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Triblock Copolymer ◽  
Amphiphilic Triblock Copolymer

scholarly journals A unique amphiphilic triblock copolymer, nontoxic to human blood and potential supramolecular drug delivery system for dexamethasone

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Irrum Mushtaq ◽  
Zareen Akhter ◽  
Muhammad Farooq ◽  
Farukh Jabeen ◽  
Ashfaq Ur Rehman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Human Blood ◽  
Self Assembly ◽  
Blood Cells ◽  
Triblock Copolymer ◽  
Computational Analysis ◽  
Amphiphilic Triblock Copolymer ◽  
Human Blood Cells

AbstractThe drug delivery system (DDS) often causes toxicity, triggering undesired cellular injuries. Thus, developing supramolecules used as DDS with tunable self-assembly and nontoxic behavior is highly desired. To address this, we aimed to develop a tunable amphiphilic ABA-type triblock copolymer that is nontoxic to human blood cells but also capable of self-assembling, binding and releasing the clinically used drug dexamethasone. We synthesized an ABA-type amphiphilic triblock copolymer (P2L) by incorporating tetra(aniline) TANI as a hydrophobic and redox active segment along with monomethoxy end-capped polyethylene glycol (mPEG2k; Mw = 2000 g mol−1) as biocompatible, flexible and hydrophilic part. Cell cytotoxicity was measured in whole human blood in vitro and lung cancer cells. Polymer-drug interactions were investigated by UV–Vis spectroscopy and computational analysis. Our synthesized copolymer P2L exhibited tuned self-assembly behavior with and without external stimuli and showed no toxicity in human blood samples. Computational analysis showed that P2L can encapsulate the clinically used drug dexamethasone and that drug uptake or release can also be triggered under oxidation or low pH conditions. In conclusion, copolymer P2L is nontoxic to human blood cells with the potential to carry and release anticancer/anti-inflammatory drug dexamethasone. These findings may open up further investigations into implantable drug delivery systems/devices with precise drug administration and controlled release at specific locations.

PTPFCBBMA-b-PEG-b-PTPFCBBMA amphiphilic triblock copolymer: Synthesis and self-assembly behavior

Polymer ◽  
2009 ◽  
Vol 50 (11) ◽  
pp. 2341-2348 ◽  
Author(s):  
Liang Tong ◽  
Zhong Shen ◽  
Dong Yang ◽  
Sheng Chen ◽  
Yongjun Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Triblock Copolymer ◽  
Amphiphilic Triblock Copolymer ◽  
Assembly Behavior

Effect of Tyrosine-Derived Triblock Copolymer Compositions on Nanosphere Self-Assembly and Drug Delivery

2007 ◽  
Vol 8 (3) ◽  
pp. 998-1003 ◽  
Author(s):  
Larisa Sheihet ◽  
Karolina Piotrowska ◽  
Robert A. Dubin ◽  
Joachim Kohn ◽  
David Devore
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Triblock Copolymer
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