The Expanding Role of Imaging in Systemic Vasculitis

2016 ◽  
Vol 42 (4) ◽  
pp. 733-751 ◽  
Author(s):  
Sergio Prieto-González ◽  
Georgina Espígol-Frigolé ◽  
Ana García-Martínez ◽  
Marco A. Alba ◽  
Itziar Tavera-Bahillo ◽  
...  
Keyword(s):  
Systemic Vasculitis

Role of therapeutic plasma exchanges in systemic vasculitis

2020 ◽  
Vol 59 (6) ◽  
pp. 102992
Author(s):  
Alexis Régent ◽  
Luc Mouthon ◽  
Loïc Guillevin ◽  
Benjamin Terrier
Keyword(s):  
Systemic Vasculitis

scholarly journals Behçet’s Disease and Tuberculosis: A Complex Relationship

2020 ◽  
Author(s):  
Sara Mendonça Freitas ◽  
Joana Silva Marques ◽  
Ana Grilo ◽  
Rodolfo Gomes ◽  
Fernando Martos Gonçalves
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Gastrointestinal Involvement ◽  
Behcet's Disease ◽  
History Of ◽  
Systemic Manifestations ◽  
Work Up

Behçet’s disease (BD) is a systemic vasculitis characterized by recurrent orogenital ulceration and several systemic manifestations (such as gastrointestinal involvement, vascular disease or arthritis). The pathogenesis is still unknown but the trigger role of certain pathogens such as Mycobacterium tuberculosis is well documented. Furthermore, patients with BD are more susceptible to tuberculosis due to immunity defects. Here, we describe the case of a 70-year-old woman with a history of recurrent oral aphthae and inflammatory arthritis presenting with extensive thrombosis of left upper limb major veins, a positive HLA B51 genotype and colon ulceration; hence, BD diagnosis was made after excluding other causes. Simultaneously, the patient had cutaneous abscesses not associated with immunosuppressive therapy with continuous development, and after recurrent negative tuberculosis work-up, M. tuberculosis was isolated in an abscess culture.

scholarly journals The Diagnostic and Clinical Utility of Autoantibodies in Systemic Vasculitis

Antibodies ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 31 ◽  
Author(s):  
Elena Csernok
Keyword(s):  
Systemic Vasculitis ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Urticarial Vasculitis ◽  
International Consensus ◽  
Anca Associated Vasculitis ◽  
Distinct Disease ◽  
A Current ◽  
Made In

Considerable progress has been made in understanding the role of autoantibodies in systemic vasculitides (SV), and consequently testing for anti-neutrophil cytoplasmic antibodies (ANCA), anti-glomerular basement membrane antibodies (anti-GBM), and anti-C1q antibodies is helpful and necessary in the diagnosis, prognosis, and monitoring of small-vessel vasculitis. ANCA-directed proteinase 3 (PR3-) or myeloperoxidase (MPO-) are sensitive and specific serologic markers for ANCA-associated vasculitides (AAV), anti-GBM antibodies are highly specific for the patients with anti-GBM antibody disease (formerly Goodpasture’s syndrome), and autoantibodies to C1q are characteristic of hypocomlementemic urticarial vasculitis syndrome (HUVS; anti-C1q vasculitis). The results of a current EUVAS study have led to changes in the established strategy for the ANCA testing in small-vessel vasculitis. The revised 2017 international consensus recommendations for ANCA detection support the primary use PR3- and MPO-ANCA immunoassays without the categorical need for additional indirect immunofluorescence (IIF). Interestingly, the presence of PR3- and MPO-ANCA have led to the differentiation of distinct disease phenotype of AAV: PR3-ANCA-associated vasculitis (PR3-AAV), MPO-ANCA-associated vasculitis (MPO-AAV), and ANCA-negative vasculitis. Further studies on the role of these autoantibodies are required to better categorize and manage appropriately the patients with small-vessel vasculitis and to develop more targeted therapy.

The Role of the Endothelium in Systemic Vasculitis

1993 ◽  
Vol 6 (2) ◽  
pp. 237-249 ◽  
Author(s):  
Caroline O.S. Savage ◽  
Stephen P. Cooke
Keyword(s):  
Systemic Vasculitis

The role of biologic therapies in the management of systemic vasculitis

2006 ◽  
Vol 5 (4) ◽  
pp. 273-278 ◽  
Author(s):  
A.T. Chan ◽  
O. Floßmann ◽  
C. Mukhtyar ◽  
D.R.W. Jayne ◽  
R.A. Luqmani
Keyword(s):  
Systemic Vasculitis ◽  
Biologic Therapies

scholarly journals Protective Role of Mast Cells in Primary Systemic Vasculitis: A Perspective

2017 ◽  
Vol 8 ◽  
Author(s):  
Jason M. Springer ◽  
Vineesh V. Raveendran ◽  
Selina A. Gierer ◽  
Mehrdad Maz ◽  
Kottarappat N. Dileepan
Keyword(s):  
Mast Cells ◽  
Systemic Vasculitis ◽  
Protective Role ◽  
Primary Systemic Vasculitis
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