scholarly journals Endocrine-disrupting chemicals and male reproductive health

2013 ◽  
Vol 26 (5) ◽  
pp. 440-448 ◽  
Author(s):  
Jure Knez
Keyword(s):  
Reproductive Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting ◽  
Male Reproductive Health

scholarly journals Changes in male reproductive health and effects of endocrine disruptors in Scandinavian countries

2002 ◽  
Vol 18 (2) ◽  
pp. 413-420 ◽  
Author(s):  
Jorma Toppari ◽  
Anne-Maarit Haavisto ◽  
Markku Alanen
Keyword(s):  
Reproductive Health ◽  
Testicular Cancer ◽  
Endocrine Disrupting Chemicals ◽  
Secular Trends ◽  
Change Points ◽  
Birth Cohorts ◽  
Endocrine Disrupting ◽  
Rapid Pace ◽  
Environmental Causes ◽  
Male Reproductive Health

Male reproductive health has deteriorated in many ways during the last decades. The incidence of testicular cancer has rapidly increased in Europe and European-derived populations. Sperm concentrations have declined and sperm motility and morphology have worsened in many areas. Both adverse trends have been shown to be associated with year of birth. Older birth cohorts have better reproductive health than the younger generations. Incidences of cryptorchidism and hypospadias have also increased according to several studies. The reasons for secular trends are unknown, but the rapid pace of the change points to environmental causes. Endocrine disrupting chemicals have been hypothesized to influence male reproductive health.

scholarly journals Endocrine‐disrupting chemicals and male reproductive health

2020 ◽  
Vol 19 (3) ◽  
pp. 243-253 ◽  
Author(s):  
Aditi Sharma ◽  
Josephine Mollier ◽  
Richard W. K. Brocklesby ◽  
Charlotte Caves ◽  
Channa N. Jayasena ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting ◽  
Male Reproductive Health

scholarly journals Endocrine disrupting chemicals and impact on male reproductive health

2018 ◽  
Vol 7 (3) ◽  
pp. 490-503 ◽  
Author(s):  
Saba Rehman ◽  
Zeenat Usman ◽  
Sabeen Rehman ◽  
Moneera AlDraihem ◽  
Noor Rehman ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting ◽  
Male Reproductive Health

Effect of endocrine disrupting chemicals on male reproductive health

2019 ◽  
Author(s):  
Aditi Sharma ◽  
Josephine Mollier ◽  
Richard WK Brocklesby ◽  
Charlotte Caves ◽  
Channa N Jayasena ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting ◽  
Male Reproductive Health

scholarly journals Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men

2021 ◽  
Vol 12 ◽  
Author(s):  
Wiwat Rodprasert ◽  
Jorma Toppari ◽  
Helena E. Virtanen
Keyword(s):  
Reproductive Health ◽  
Testicular Cancer ◽  
Semen Quality ◽  
Endocrine Disrupting Chemicals ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Sensitive Period ◽  
Testicular Development ◽  
Reproductive Disorders ◽  
Endocrine Disrupting

Male reproductive health has declined as indicated by increasing rates of cryptorchidism, i.e., undescended testis, poor semen quality, low serum testosterone level, and testicular cancer. Exposure to endocrine disrupting chemicals (EDCs) has been proposed to have a role in this finding. In utero exposure to antiandrogenic EDCs, particularly at a sensitive period of fetal testicular development, the so-called ‘masculinization programming window (MPW)’, can disturb testicular development and function. Low androgen effect during the MPW can cause both short- and long-term reproductive disorders. A concurrent exposure to EDCs may also affect testicular function or damage testicular cells. Evidence from animal studies supports the role of endocrine disrupting chemicals in development of male reproductive disorders. However, evidence from epidemiological studies is relatively mixed. In this article, we review the current literature that evaluated relationship between prenatal EDC exposures and anogenital distance, cryptorchidism, and congenital penile abnormality called hypospadias. We review also studies on the association between early life and postnatal EDC exposure and semen quality, hypothalamic-pituitary-gonadal axis hormone levels and testicular cancer.

scholarly journals The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm

Reproduction ◽  
2016 ◽  
Vol 151 (1) ◽  
pp. R1-R13 ◽  
Author(s):  
R S Tavares ◽  
S Escada-Rebelo ◽  
M Correia ◽  
P C Mota ◽  
J Ramalho-Santos
Keyword(s):  
Sperm Quality ◽  
Synergistic Effects ◽  
Endocrine Disrupting Chemicals ◽  
Reproductive Organs ◽  
Mammalian Sperm ◽  
Animal Populations ◽  
Endocrine Disrupting ◽  
Intracellular Ca ◽  
Genomic Effects ◽  
Male Reproductive Health

Exposure to toxicants present in the environment, especially the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in male reproductive organs over the past decades. Both human and animal populations are continuously exposed to ubiquitous synthetic and natural-occurring EDCs through diet, dermal contact and/or inhalation, therefore potentially compromising male reproductive health. Although the effects of EDC are likely induced via multiple genomic-based pathways, their non-genomic effects may also be relevant. Furthermore, spermatozoa are transcriptionally inactive cells that can come in direct contact with EDCs in reproductive fluids and secretions and are therefore a good model to address non-genomic effects. This review thus focuses on the non-genomic effects of several important EDCs relevant to mammalian exposure. Notably, EDCs were found to interfere with pre-existing pathways inducing a panoply of deleterious effects to sperm function that included altered intracellular Ca2+oscillations, induction of oxidative stress, mitochondrial dysfunction, increased DNA damage and decreased sperm motility and viability, among others, potentially jeopardizing male fertility. Although many studies have used non-environmentally relevant concentrations of only one compound for mechanistic studies, it is important to remember that mammals are not exposed to one, but rather to a multitude of environmental EDCs, and synergistic effects may occur. Furthermore, some effects have been detected with single compounds at environmentally relevant concentrations.

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