scholarly journals Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder

2019 ◽  
Vol 64 ◽  
pp. 31-38 ◽  
Author(s):  
B. Blair Braden ◽  
Cory Riecken
Keyword(s):  
Autism Spectrum Disorder ◽  
Cortical Thickness ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Adults With Autism ◽  
Age Related

scholarly journals Atypical age-related changes in cortical thickness in autism spectrum disorder

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Adonay S. Nunes ◽  
Vasily A. Vakorin ◽  
Nataliia Kozhemiako ◽  
Nicholas Peatfield ◽  
Urs Ribary ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cortical Thickness ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Age Related ◽  
Age Related Changes

scholarly journals Atypical developmental features of cortical thickness trajectories in Autism Spectrum Disorder

2019 ◽  
Author(s):  
Adonay S Nunes ◽  
Vasily A Vakorin ◽  
Nataliia Kozhemiako ◽  
Nicholas Peatfield ◽  
Urs Ribary ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cortical Thickness ◽  
Developmental Trajectories ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Quadratic Model ◽  
Group Differences ◽  
Age Related ◽  
Developmental Features ◽  
Age Related Changes

AbstractNeuroimaging studies have reported numerous region-specific atypicalities in the brains of individuals with Autism Spectrum Disorder (ASD), including alterations in cortical thickness (CT). However, there are many inconsistent findings, and this is probably due to atypical CT developmental trajectories in ASD. To this end, we investigated group differences in terms of shapes of developmental trajectories of CT between ASD and typically developing (TD) populations.Using the Autism Brain Imaging Data Exchange (ABIDE) repository (releases I and II combined), we investigated atypical shapes of developmental trajectories in ASD using a linear, quadratic and cubic models at various scales of spatial coarseness, and their association with symptomatology using the Autism Diagnostic Observation Schedule (ADOS) scores. These parameters were also used to predict ASD and TD CT development.While no overall group differences in CT was observed across the entire age range, ASD and TD populations were different in terms of age-related changes. Developmental trajectories of CT in ASD were mostly characterized by decreased cortical thinning during early adolescence and increased thinning at later stages, involving mostly frontal and parietal areas. Such changes were associated with ADOS scores. The curvature of the trajectories estimated from the quadratic model was the most accurate and sensitive measure for detecting ASD. Our findings suggest that under the context of longitudinal changes in brain morphology, robust detection of ASD would require three time points to estimate the curvature of age-related changes.

scholarly journals Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jannath Begum-Ali ◽  
◽  
Anna Kolesnik-Taylor ◽  
Isabel Quiroz ◽  
Luke Mason ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Auditory Processing ◽  
Neurofibromatosis Type ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Type I ◽  
Sensory Reactivity ◽  
Auditory Responses ◽  
Repetition Suppression ◽  
Age Related

Abstract Background Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.

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