Clarithromycin ameliorates pulmonary inflammation induced by short term cigarette smoke exposure in mice

2015 ◽  
Vol 35 ◽  
pp. 60-66 ◽  
Author(s):  
Masuo Nakamura ◽  
Hiroo Wada ◽  
Kojiro Honda ◽  
Keitaro Nakamoto ◽  
Toshiya Inui ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

SHORT-TERM CIGARETTE SMOKE EXPOSURE POTENTIATES ENDOTOXIN-INDUCED PULMONARY INFLAMMATION

2007 ◽  
Vol 33 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Girish S. Kulkarni ◽  
Priya P. Nadkarni ◽  
Joseph M. Cerreta ◽  
Shuren Ma ◽  
Jerome O. Cantor
Keyword(s):  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

scholarly journals Acute pulmonary inflammation is inhibited in CXCR3 knockout mice after short-term cigarette smoke exposure

2008 ◽  
Vol 29 (12) ◽  
pp. 1432-1439 ◽  
Author(s):  
Li Nie ◽  
Ruo-lan Xiang ◽  
Yong Liu ◽  
Wei-xun Zhou ◽  
Lei Jiang ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Knockout Mice ◽  
Pulmonary Inflammation ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

Changes in Eustachian Tube Mucosa in Mice After Short‐Term Tobacco and E‐cigarette Smoke Exposure

2021 ◽  
Author(s):  
Brian D. Nicholas ◽  
Aleksandar Kiprovski ◽  
Diandra Perez ◽  
Rohin Mehta ◽  
Michael K. Murphy ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Eustachian Tube ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

scholarly journals Pneumocystis murina Infection and Cigarette Smoke Exposure Interact To Cause Increased Organism Burden, Development of Airspace Enlargement, and Pulmonary Inflammation in Mice

2008 ◽  
Vol 76 (8) ◽  
pp. 3481-3490 ◽  
Author(s):  
Paul J. Christensen ◽  
Angela M. Preston ◽  
Tony Ling ◽  
Ming Du ◽  
W. Bradley Fields ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Airflow Obstruction ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Chronic Obstructive ◽  
Respiratory Pathogens ◽  
Obstructive Pulmonary Disease ◽  
Immunocompetent Mice

ABSTRACT Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow obstruction and lung destruction with airspace enlargement. In addition to cigarette smoking, respiratory pathogens play a role in pathogenesis, but specific organisms are not always identified. Recent reports demonstrate associations between the detection of Pneumocystis jirovecii DNA in lung specimens or respiratory secretions and the presence of emphysema in COPD patients. Additionally, human immunodeficiency virus-infected individuals who smoke cigarettes develop early emphysema, but a role for P. jirovecii in pathogenesis remains speculative. We developed a new experimental model using immunocompetent mice to test the interaction of cigarette smoke exposure and environmentally acquired Pneumocystis murina infection in vivo. We hypothesized that cigarette smoke and P. murina would interact to cause increases in total lung capacity, airspace enlargement, and pulmonary inflammation. We found that exposure to cigarette smoke significantly increases the lung organism burden of P. murina. Pulmonary infection with P. murina, combined with cigarette smoke exposure, results in changes in pulmonary function and airspace enlargement characteristic of pulmonary emphysema. P. murina and cigarette smoke exposure interact to cause increased lung inflammatory cell accumulation. These findings establish a novel animal model system to explore the role of Pneumocystis species in the pathogenesis of COPD.

Short-Term Cigarette Smoke Exposure Predisposes the Lung to Secondary Injury

Lung ◽  
2007 ◽  
Vol 185 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Tapan M. Bhavsar ◽  
Joseph M. Cerreta ◽  
Jerome O. Cantor
Keyword(s):  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Secondary Injury ◽  
Short Term

scholarly journals Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure

2017 ◽  
Vol 10 (6) ◽  
pp. 1400-1411 ◽  
Author(s):  
F M Verhamme ◽  
L J M Seys ◽  
E G De Smet ◽  
S Provoost ◽  
W Janssens ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure
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