Short-term regulation of the hepatic activities of cytochrome P450 and glutathione S-transferase by nose-only cigarette smoke exposure in mice

2019 ◽  
Vol 125 ◽  
pp. 182-189 ◽  
Author(s):  
Chang Seon Ryu ◽  
Young Jae Choi ◽  
Hyo Seon Nam ◽  
Jang Su Jeon ◽  
Taeyoon Jung ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Glutathione S Transferase ◽  
Short Term

Changes in Eustachian Tube Mucosa in Mice After Short‐Term Tobacco and E‐cigarette Smoke Exposure

2021 ◽  
Author(s):  
Brian D. Nicholas ◽  
Aleksandar Kiprovski ◽  
Diandra Perez ◽  
Rohin Mehta ◽  
Michael K. Murphy ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Eustachian Tube ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

Clarithromycin ameliorates pulmonary inflammation induced by short term cigarette smoke exposure in mice

2015 ◽  
Vol 35 ◽  
pp. 60-66 ◽  
Author(s):  
Masuo Nakamura ◽  
Hiroo Wada ◽  
Kojiro Honda ◽  
Keitaro Nakamoto ◽  
Toshiya Inui ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

Short-Term Cigarette Smoke Exposure Predisposes the Lung to Secondary Injury

Lung ◽  
2007 ◽  
Vol 185 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Tapan M. Bhavsar ◽  
Joseph M. Cerreta ◽  
Jerome O. Cantor
Keyword(s):  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Secondary Injury ◽  
Short Term

SHORT-TERM CIGARETTE SMOKE EXPOSURE POTENTIATES ENDOTOXIN-INDUCED PULMONARY INFLAMMATION

2007 ◽  
Vol 33 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Girish S. Kulkarni ◽  
Priya P. Nadkarni ◽  
Joseph M. Cerreta ◽  
Shuren Ma ◽  
Jerome O. Cantor
Keyword(s):  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

scholarly journals Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx

2021 ◽  
Author(s):  
Meena Easwaran ◽  
Joshua D. Martinez ◽  
Daniel J. Ramirez ◽  
Phillip A. Gall ◽  
Elizabeth Erickson-DiRenzo
Keyword(s):  
Cigarette Smoke ◽  
Regional Differences ◽  
Cellular Response ◽  
Smoke Exposure ◽  
Whole Body ◽  
Cigarette Smoke Exposure ◽  
Short Term

scholarly journals Activity of Cytochrome p450 as a Steroidogenesis and Oxidation Catalyst of Cholesterol in Experimental Animals Exposed to Cigarette Smoke

2021 ◽  
Vol 9 (A) ◽  
pp. 352-355
Author(s):  
Arni Amir ◽  
M. Saka Abeiasa ◽  
Oktavianis Oktavianis
Keyword(s):  
Cytochrome P450 ◽  
Cholesterol Level ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Oxidation Catalyst ◽  
Cigarette Smoke Exposure ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cytochrome P450 Enzyme ◽  
Cholesterol Levels ◽  
P450 Enzyme

BACKGROUND: Basically, body regulates various harmful substances, including nicotine and tar which were carried by cigarette smoke. Nicotine which accumulated in blood was transported to liver to be metabolized and excreted in kidneys. The metabolism of nicotine into a harmless substance to body is closely related to the role of cytochrome P450 enzyme. In liver, nicotine was catalyzed by cytochrome P450 to be intermediate nicotine-Δ-1 ‘(5’) - iminium ion. The elevation of cholesterol leads the P450 to discard overage cholesterol to keep cholesterol homeostasis and atheroprotection. AIM: The aim of the study was to determine the activity of cytochrome P450 to cigarette smoke exposure and to cholesterol level. MATERIALS AND METHODS: A total of 32 Rattus norvegicus male Wistar albino strain was exposed to cigarette smoke with a different number of cigarettes for 57 weeks (2, 3, and 4 cigarette/day group, with a group of control). In the 58th week, the blood of rats was collected for enzyme-linked immunosorbent assay analysis. RESULTS: Both cytochrome P450 activity and cholesterol level affected to cigarette smoke exposure (p > 0.05, 0.00 for cholesterol levels and 0.04 for p450 levels). CONCLUSIONS: Exposure of cigarette smoke significantly has an impact on increasing cholesterol levels and decreasing the activity of P450 enzyme. The elevating of cigarette number had a significant impact between the smoker and non-smoker groups.

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