Analytical hierarchy processes (AHP) for the selection of solvents in early stages of pharmaceutical process development

2011 ◽  
Vol 89 (4) ◽  
pp. 261-267 ◽  
Author(s):  
S. Perez-Vega ◽  
Senior Peter ◽  
I. Salmeron-Ochoa ◽  
A. Nieva-de la Hidalga ◽  
P.N. Sharratt
Keyword(s):  
Process Development ◽  
Early Stages ◽  
Selection Of

A New Method of Blunt Cartilage Impact for a Model of Osteoarthritis

2008 ◽  
Author(s):  
Stephen Fening ◽  
Morgan Jones ◽  
Vasilios Moutzouros ◽  
Anthony Miniaci
Keyword(s):  
Process Development ◽  
New Method ◽  
Cartilage Injury ◽  
Degenerative Osteoarthritis ◽  
Novel Treatments ◽  
Early Stages ◽  
Reliable Model ◽  
Joint Trauma ◽  
Pharmacologic Agents ◽  
Impact Injury

Impact injury to cartilage, a common consequence of joint trauma, is commonly thought to lead to degenerative osteoarthritis. Many pharmacologic agents have been developed to prevent or forestall this process. Development of a reliable model for the early stages of cartilage injury and osteoarthritis would enable the testing of novel treatments that could delay or even reverse the progression of this debilitating disease.

Research Methodology for Microwave-Convective Processing of Grain

2020 ◽  
Vol 9 (2) ◽  
pp. 1-11 ◽  
Author(s):  
Aleksey N. Vasiliev ◽  
V.P. Goryachkina ◽  
Dmitry Budnikov
Keyword(s):  
Research Methodology ◽  
Process Development ◽  
Physical Analysis ◽  
Exchange Processes ◽  
Heat And Moisture ◽  
Adequate Research ◽  
Development Application ◽  
Complicated Task ◽  
Selection Of ◽  
Mathematical Simulation Methods

Studying the effect of microwave fields on the intensification of heat and moisture exchange processes in a granular layer is a rather complicated task, which cannot be effectively solved without an adequate research methodology. In presented materials, a system of principles and approaches for studying processes of microwave-convective grain treatment has been discussed. Based on the explicitly defined process target, functional-physical analysis has been performed that made it possible to specify the most essential factors of process. Morphological analysis of processes shall be performed in several stages. At each stage, targets of process have to be set by excluding combinations of factors that have no reason to be considered at this particular stage of process development. Application of mathematical simulation methods is advisable for selection of optimal options.

scholarly journals MEWUJUDKAN PUSTAKAWAN KEMENTERIAN KESEHATAN YANG KOMPETEN DAN PROFESIONAL MELALUI PEMILIHAN PUSTAKAWAN INOVATIF TERBAIK

2022 ◽  
Vol 2 (1) ◽  
pp. 8-15
Author(s):  
RESTY KIANTINI
Keyword(s):  
Best Practice ◽  
Process Development ◽  
Scientific Paper ◽  
Intellectual Life ◽  
Ministry Of Health ◽  
Service Award ◽  
The One ◽  
Selection Of

  The Ministry of Health Library is a builder library for libraries and librarians within the Ministry of Health spread throughout Indonesia. The success of the library is largely determined by the role of the librarian. Because the librarian is a profession that has a major contribution in realizing the noble ideals of the Indonesian nation in the intellectual life of the nation. Based on this, the Ministry of Health Library held a Selection of the Best Innovative Librarian. The method used in writing this scientific paper is best practice. Best Practice is an idea or new steps that make an outstanding, sustainable and innovative contribution in improving the process development and quality of education. Best Practice needs to be disseminated to others with various strategies in various places repeatedly so that it can be imitated and adopted by others. The selection of the Best Innovative Librarian was carried out in several stages. Starting from making the TOR for activities, entering activity items into the RKAKL, determining the theme of the activity, making guidelines, compiling a Committee Decree. The Best Innovative Librarian Assessment is done by looking at the completeness of documents, innovation papers and presentations. The one who gets the best score from the jury will be designated as the Best Innovative Librarian within the Ministry of Health. The Best Innovative Librarian 1 to 3 and expectations 1 to 3. The Best Innovative Librarian received awards and prizes at the Publication and Public Service Award Night of the Ministry of Health which was attended by the Minister of Health, Menpan-RB and the Head of the National Library. Librarians are the main key to the sustainability and success of a library. The selection of the Best Innovative Librarian was held as a form of appreciation and appreciation for librarians within the Ministry of Health. It is hoped that this activity can motivate librarians in the Ministry of Health to continue to work, innovate, perform and excel and have competitiveness with other professions. ABSTRAKPerpustakaan Kementerian Kesehatan merupakan perpustakaan pembina bagi perpustakaan dan pustakawan di lingkungan Kementerian Kesehatan yang tersebar di seluruh Indonesia. Keberhasilan perpustakaan sangat ditentukan oleh peran Pustakawan. Karena pustakawan merupakan profesi yang memiliki kontribusi besar dalam mewujudkan cita-cita luhur bangsa Indonesia dalam mencerdaskan kehidupan bangsa. Berdasarkan hal tersebut Perpustakaaan Kementerian Kesehatan menyelenggarakan Pemilihan Pustakawan Inovatif Terbaik. Metode yang digunakan dalam penulisan karya ilmiah ini adalah best practise. Best Practice adalah suatu ide atau langkah-langkah baru yang memberikan kontribusi luar biasa, berkesinambungan dan inovatif dalam memperbaiki pengembangan proses dan kualitas pendidikan. Best Practice perlu didiseminasikan kepada orang lain dengan berbagai strategi diberbagai tempat secara berulang-ulang sehingga dapat dicontoh dan diadopsi oleh orang lain. Pemilihan Pustakawan Inovatif Terbaik dilaksanakan melalui beberapa tahap. Diawali dari pembuatan TOR kegiatan, memasukkan butir kegiatan kedalam RKAKL, menentukan tema kegiatan, membuat pedoman, menyusun SK Kepanitiaan. Penilaian Pustakawan Inovatif Terbaik dilakukan dengan cara melihat kelengkapan dokumen, makalah inovasi dan presentasi. Yang mendapat nilai terbaik dari dewan juri akan ditetapkan sebagai Pustakawan Inovatif Terbaik di lingkungan Kementerian Kesehatan. Terpilih Pustakawan Inovatif Terbaik 1 sd 3 dan harapan 1 s/d 3. Pustakawan Inovatif Terbaik mendapatkan penghargaan dan hadiah di Malam Penghargaan Publikasi dan Pelayanan Publik Kementerian Kesehatan yang dihadiri oleh Menkes, Menpan-RB dan Kepala Perpusnas. Pustakawan menjadi kunci utama keberlangsungan dan keberhasilan sebuah perpustakaan. Pemilihan Pustakawan Inovatif Terbaik dilaksanakan sebagai suatu bentuk apresiasi dan penghargaan kepada pustakawan di lingkungan Kementerian Kesehatan. Diharapkan dengan adanya kegiatan ini dapat memotivasi pustakawan di lingkungan Kementerian Kesehatan untuk terus berkarya, berinovasi, berkinerja dan berprestasi serta memiliki daya saing dengan profesi lainnya.

scholarly journals Process Development and Scale-up Optimization of the SARS-CoV-2 Receptor Binding Domain-Based Vaccine Candidate, RBD219-N1C1

2020 ◽  
Author(s):  
Jungsoon Lee ◽  
Zhuyun Liu ◽  
Wen-Hsiang Chen ◽  
Junfei Wei ◽  
Rakhi Kundu ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Process Development ◽  
Low Cost ◽  
Scale Up ◽  
Neutralizing Antibody ◽  
Protein Antigen ◽  
Purification Process ◽  
Good Manufacturing Practices ◽  
Purification Methods ◽  
Selection Of

AbstractA SARS-CoV-2 RBD219-N1C1 (RBD219-N1C1) recombinant protein antigen formulated on Alhydrogel® has recently been shown to elicit a robust neutralizing antibody response against SARS-CoV-2 pseudovirus in mice. The antigen has been produced under current good manufacturing practices (cGMP) and is now in clinical testing. Here, we report on process development and scale-up optimization for upstream fermentation and downstream purification of the antigen. This includes production at the 1 and 5 L scale in the yeast, Pichia pastoris, and the comparison of three different chromatographic purification methods. This culminated in the selection of a process to produce RBD219-N1C1 with a yield of >400 mg per liter of fermentation with >92% purity and >39% target product recovery after purification. In addition, we show the results from analytical studies, including SEC-HPLC, DLS, and an ACE2 receptor binding assay that were performed to characterize the purified proteins to select the best purification process. Finally, we propose an optimized upstream fermentation and downstream purification process that generates quality RBD219-N1C1 protein antigen and is fully scalable at a low cost.

Through-Sapphire Via Filling Process Development for Backside Interconnect and Chip Stacking and Front-to-Back Daisy Chain Chip

2014 ◽  
Vol 2014 (DPC) ◽  
pp. 001422-001434
Author(s):  
Syed Sajid Ahmad ◽  
Fred Haring ◽  
Aaron Reinholz ◽  
Nathan Schneck
Keyword(s):  
Electron Microscope ◽  
Heat Affected Zone ◽  
Process Development ◽  
Electronic Systems ◽  
Drilling Process ◽  
Filling Process ◽  
Designed Experiments ◽  
Drilling Parameters ◽  
Laser Systems ◽  
Selection Of

With increasing need for electronic systems miniaturization to provide greater functionality in hand-held devices, through-sapphire via paves a way for the greater densification of silicon-on-sapphire devices and systems. Evaluations of two laser systems for via drilling in blank and device sapphire are outlined. Designed experiments were conducted to optimize the process and to minimize sapphire-via parasites (debris and heat-affected zone). Optical and electron microscope observations and measurements were conducted. Effects of varying via drilling techniques were evaluated for via shape and amount of parasitic effects. Laser via-drilling parameters were also evaluated for their effect on via quality. Results of the study show that acceptable through-sapphire via can be achieved and the parasites minimized with the selection of proper equipment and optimization of the drilling process.

Prosodic accommodation in language contact: Spanish intonation in Majorca

2013 ◽  
Vol 2013 (221) ◽  
Author(s):  
Magdalena Romera ◽  
Gorka Elordieta
Keyword(s):  
Language Contact ◽  
Native Speaker ◽  
Spanish Speakers ◽  
Prosodic Features ◽  
Native Spanish Speakers ◽  
Early Stages ◽  
Contact Situation ◽  
Set Up ◽  
Selection Of

AbstractIn this article we study a language contact situation in Majorca, Spain, in which adult monolingual speakers of Spanish who arrived recently in Majorca acquire aspects of Majorcan Catalan prosody. Although the possibility that the adoption of features can take place directly from Catalan is not rejected, we provide evidence that it can be an indirect process, through a process of accommodation (Trudgill 1986; Giles and Coupland 1991) to the L2 variety of Spanish spoken by L1 Majorcan Catalan speakers. An experiment was set up in which we recorded four native Spanish speakers who arrived recently in Majorca holding a semi-directed conversation in Spanish with a native speaker of Majorcan Catalan. The results showed consistent adoption of prosodic features of L2 Majorcan Spanish in interrogative sentences (not in declaratives). The results support the idea that the adoption of prosodic features of Majorcan Catalan by monolingual Spanish speakers can take place in early stages of contact. Our article also shows that subjective factors such as determination towards integration play a fundamental role in determining the degree of accommodation. Finally, salience of prosodic features is claimed to play a role in the selection of transferred features.

Priming overgeneralizations in two- and four-year-old children

2006 ◽  
Vol 33 (3) ◽  
pp. 461-486 ◽  
Author(s):  
LISA GERSHKOFF-STOWE ◽  
BRENDA CONNELL ◽  
LINDA SMITH
Keyword(s):  
Language Processing ◽  
Word Learning ◽  
Test Object ◽  
Correct Selection ◽  
Common Mechanism ◽  
Target Category ◽  
Theoretical Account ◽  
Early Stages ◽  
Novel Objects ◽  
Selection Of

Overgeneralization occurs when a child uses the wrong word to name an object and is often observed in the early stages of word learning. We develop a method to elicit overgeneralizations in the laboratory by priming children to say the names of objects perceptually similar to known and unknown target objects. Experiment 1 examined 18 two-year-old children's labelling of familiar and unfamiliar objects, using a name that was previously produced. Experiment 2 compared the labelling of 30 two-year-olds and 39 four-year-olds when presented with completely novel objects. The findings suggest that the retrieved word is a blend of previous activation from the prior retrieval and activation engendered by the similarity of the test object to instances of the target category. We put forward a theoretical account of overgeneralization based on current models of adult language processing. The account suggests a common mechanism of activation and retrieval, which may explain not only momentary lapses in the correct selection of words, but other types of naming errors traditionally thought to reflect differences in children's underlying category representations or, perhaps, gaps in their knowledge of words.

The Investment Arbitration Practitioner: Chiara Giorgetti (ed.), Litigating International Investment Disputes: A Practitioner’s Guide.

2016 ◽  
pp. 295-318
Author(s):  
Robert G. Volterra ◽  
Giorgio Francesco Mandelli ◽  
Maria Fogdestam Agius
Keyword(s):  
Dispute Settlement ◽  
International Investment ◽  
Reference Guide ◽  
Early Stages ◽  
Investment Arbitration ◽  
Procedural Decisions ◽  
Selection Of

Among practical guides to international investment arbitration, Litigating International Investment Disputes stands out due to both its practitioner-friendly selection of topics and in its approach to discussing the myriad milestones of investment dispute proceedings. The contributing authors underline the strategic importance of making procedural decisions in the early stages of the dispute settlement process and offer concrete suggestions on how to use the special nature of investment arbitration to a client’s advantage. Despite omitting a number of helpful topics, and overburdening some chapters with excessive descriptive detail, Litigating International Investment Disputes should serve as a useful companion tool and reference guide, particularly for the less-seasoned investment arbitration practitioner.

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