HER2 status in sinonasal intestinal-type adenocarcinoma

2019 ◽  
Vol 215 (6) ◽  
pp. 152432 ◽  
Author(s):  
Valeria Maffeis ◽  
Rocco Cappellesso ◽  
Alessia Zanon ◽  
Diego Cazzador ◽  
Enzo Emanuelli ◽  
...  
Keyword(s):  
Intestinal Type ◽  
Her2 Status ◽  
Intestinal Type Adenocarcinoma

HER2 status in gastroesophageal cancer: An Irish multicenter experience.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 28-28
Author(s):  
Aine O'Reilly ◽  
Catherine Quinlan ◽  
Ciara Marie Kelly ◽  
Ciara Ryan ◽  
Margaret O'Keeffe ◽  
...  
Keyword(s):  
Early Stage ◽  
Intestinal Type ◽  
Her2 Status ◽  
Gastroesophageal Cancer ◽  
Diffuse Type ◽  
Her2 Positive ◽  
Clinicopathologic Characteristics ◽  
Localized Disease ◽  
Intestinal Type Adenocarcinoma ◽  
Type 3

28 Background: Gastroesophageal cancer is a major cause of cancer-related mortality. The ToGA study, established the benefit of trastuzumab in combination with chemotherapy in HER2 positive metastatic gastroesophageal tumors. We report a multi-centre Irish experience of examining HER2 status by IHC and FISH amongst gastroesophageal adenocarcinomas. Methods: HER2 testing was performed on biopsy or resection specimens of patients with early stage and metastatic gastroesophageal tumors between 2010 and 2012. We defined HER2 positive(+) as IHC3+ or FISH(+) {HER2:17ch ≥2}. All specimens which were IHC2+ or IHC3+, where treatment with trastuzumab was under consideration, went on to have FISH testing. Results: Between 2010 and 2012 HER2 status was established in all patients presenting with biopsy proven gastroesophageal cancers, this amounted to 88 patients (53 gastric, 35 esophageal). Within the population examined 64% of patients had metastatic disease. The majority (51%) had intestinal type adenocarcinomas, the remainder having diffuse type (16%), mixed type (3%) or undetermined (18%). Nineteen patients (21%) were defined as being HER2+ (14 male, 5 female). Four were FISH (+) IHC3+, five were FISH (+) IHC2+ and in ten patients HER2 status was defined by IHC3+ alone as FISH testing was indeterminate (1 patient) or not tested (9 patients). In the subset of HER2+ patients (19 patients), the majority had gastric cancer (63%). Intestinal type adenocarcinoma occurred in 12 patients (63%), the remainder being diffuse type (2 patients), mixed (1 patient) or undetermined (4 patients). Seven patients (36%) had localized disease. In the metastatic cases the distribution of metastases was as follows: 9(47%) liver, 3(15%) lung, 3(15%) peritoneal, 1(5%) adrenal, 1(5%) brain and 1(5%) ovarian. Five patients are receiving trastuzumab for HER2+ disease in combination with cisplatin and fluorouracil based chemotherapy. Conclusions: In a cohort of Irish patients we found similar levels of HER2+ gastroesophageal cancers (21%) as that demonstrated in the ToGA trial (22%). Clinicopathologic characteristics were broadly similar also. Outcome of our experience with HER2 directed therapy will be reported.

Comparison of HER2 status between surgically resected specimens and matched biopsy specimens of gastric intestinal-type adenocarcinoma

2014 ◽  
Vol 465 (2) ◽  
pp. 145-154 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Noriko Yamamoto ◽  
Hirokazu Taniguchi ◽  
Ichiro Oda ◽  
Hitoshi Katai ◽  
...  
Keyword(s):  
Intestinal Type ◽  
Her2 Status ◽  
Biopsy Specimens ◽  
Intestinal Type Adenocarcinoma

scholarly journals Nasopharyngeal non-intestinal-type adenocarcinoma: a case report and updated review of the literature

2017 ◽  
Vol 24 (1) ◽  
pp. 55 ◽  
Author(s):  
C. Jain ◽  
L. Caulley ◽  
K.I. Macdonald ◽  
B. Purgina ◽  
C.K. Lai ◽  
...  
Keyword(s):  
Radiation Treatment ◽  
Rare Condition ◽  
Intestinal Type ◽  
World Health ◽  
Primary Radiation ◽  
High Grade ◽  
Rare Tumours ◽  
Intestinal Type Adenocarcinoma ◽  
Health Organization ◽  
Nasopharyngeal Masses

Background Non-intestinal-type adenocarcinoma is a malignancy traditionally found in the sinonasal cavity. To our knowledge, this case is the first reported of this rare condition originating in the nasopharynx.Case Presentation A 67-year-old woman with nasopharyngeal non-intestinal-type adenocarcinoma, with an accompanying parapharyngeal mass received primary radiation treatment for both lesions. Her tumour subsequently persisted, with a concomitant conversion in pathology from a low- to a high-grade malignancy.Results Non-intestinal-type and intestinal-type adenocarcinomas of the nasopharynx are extremely rare tumours and do not appear in the World Health Organization classification system. We review the pathophysiologic features of these malignancies and propose modifications to the current classification system.Conclusions Non-intestinal-type adenocarcinoma should be included in the differential diagnosis of nasopharyngeal masses. In our experience, this tumour in this location showed a partial response to primary radiation but later converted from a low- to a high-grade adenocarcinoma.

scholarly journals RHOA mutations and CLDN18-ARHGAP fusions in intestinal-type adenocarcinoma with anastomosing glands of the stomach

2018 ◽  
Vol 32 (4) ◽  
pp. 568-575 ◽  
Author(s):  
Taiki Hashimoto ◽  
Reiko Ogawa ◽  
Tzu-Yin Tang ◽  
Hiroshi Yoshida ◽  
Hirokazu Taniguchi ◽  
...  
Keyword(s):  
Intestinal Type ◽  
Intestinal Type Adenocarcinoma

scholarly journals Sinonasal Non–Intestinal-Type Adenocarcinoma: A Retrospective Review of 22 Patients

2018 ◽  
Vol 120 ◽  
pp. e962-e969 ◽  
Author(s):  
Maurizio Bignami ◽  
Davide Lepera ◽  
Luca Volpi ◽  
Alessia Lambertoni ◽  
Alberto Arosio ◽  
...  
Keyword(s):  
Retrospective Review ◽  
Intestinal Type ◽  
Intestinal Type Adenocarcinoma

Intestinal-type adenocarcinoma of the larynx: Report of a rare aggressive phenotype and discussion of histogenesis

Head & Neck ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. E44-E47 ◽  
Author(s):  
Diana Bell ◽  
Floyd Christopher Holsinger ◽  
Nelson Ordonez ◽  
Adel K. El-Naggar
Keyword(s):  
Intestinal Type ◽  
Aggressive Phenotype ◽  
Intestinal Type Adenocarcinoma

Intestinal-Type Adenocarcinoma of the Sinonasal Tract: A Clinicopathologic Study of 18 Cases

1993 ◽  
Vol 79 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Carmelo Urso ◽  
Maria Benedetta Ninu ◽  
Alessandro Franchi ◽  
Milena Paglierani ◽  
Roberto Bondi
Keyword(s):  
Intestinal Type ◽  
Presenting Symptoms ◽  
Clinicopathologic Study ◽  
Clinicopathologic Findings ◽  
Poorly Differentiated ◽  
Intestinal Type Adenocarcinoma ◽  
Aggressive Tumors ◽  
Well Differentiated ◽  
Colonic Adenocarcinomas

Background Intestinal-type adenocarcinoma (ITAC) of the nose and paranasal sinuses is a relatively rare tumor. It commonly affects subjects exposed to wood or leather dust. Methods The authors present the clinicopathologic findings of 18 cases of sinonasal ITACs and review the proposed histologic classifications. Results All patients, except one, were males; mean age was 60 years (range, 41-79); in 9 cases an occupational exposure to wood or leather dust was found. Common presenting symptoms were epistaxis, nasal obstruction and rhinorrhea. Histologically, tumors were divided into four groups: well-differentiated (G1) ITACs = 3 cases; moderately differentiated (G2) ITACs = 8 cases; poorly differentiated (G3) ITACs = 2 cases; mucinous (M) ITACs = 5 cases. Immunocytochemically, 16/17 cases were positive for carcinoembryonal antigen, 1/17 for somatostatin, and 0/16 cases for gastrin. Conclusions Sinonasal ITACs are aggressive tumors, often diagnosed in a relatively advanced stage. Owing the close similarity of the microscopic aspects, a histologic classification of ITACs analogous to that of colonic adenocarcinomas is proposed.

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