PCR-based clonality analysis of B-cell lymphomas in paraffin-embedded tissues: Diagnostic value of immunoglobulin κ and λ light chain gene rearrangement investigation

2006 ◽  
Vol 202 (6) ◽  
pp. 425-431 ◽  
Author(s):  
Khaled Amara ◽  
Mounir Trimeche ◽  
Sonia Ziadi ◽  
Badreddine Sriha ◽  
Moncef Mokni ◽  
...  
Keyword(s):  
B Cell ◽  
Light Chain ◽  
Gene Rearrangement ◽  
Diagnostic Value ◽  
Chain Gene ◽  
B Cell Lymphomas ◽  
Light Chain Gene ◽  
Clonality Analysis ◽  
Chain Gene Rearrangement ◽  
Λ Light Chain

scholarly journals ImmunoglobulinλGene Rearrangement Can PrecedeκGene Rearrangement

1990 ◽  
Vol 1 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Jörg Berg ◽  
Mindy Mcdowell ◽  
Hans-Martin Jäck ◽  
Matthias Wabl
Keyword(s):  
B Cell ◽  
Heavy Chain ◽  
Light Chain ◽  
Gene Rearrangement ◽  
Germ Line ◽  
Stochastic Theory ◽  
Chain Gene ◽  
Light Chain Gene ◽  
Line Configuration ◽  
Chain Gene Rearrangement

Immunoglobulin genes are generated during differentiation of B lymphocytes by joining gene segments. A mouse pre-B cell contains a functional immunoglobulin heavy-chain gene, but no light-chain gene. Although there is only one heavy-chain locus, there are two lightchain loci:κandλ.It has been reported thatκloci in the germ-line configuration are never (in man) or very rarely (in the mouse) present in cells with functionally rearrangedλ-chain genes. Two explanations have been proposed to explain this: (a) the ordered rearrangement theory, which postulates that light-chain gene rearrangement in the pre-B cell is first attempted at theκlocus, and that only upon failure to produce a functionalκchain is there an attempt to rearrange theλlocus; and (b) the stochastic theory, which postulates that rearrangement at theλlocus proceeds at a rate that is intrinsically much slower than that at theκlocus. We show here thatλ-chain genes are generated whether or not theκlocus has lost its germ-line arrangement, a result that is compatible only with the stochastic theory.

scholarly journals Bruton’s Tyrosine Kinase and SLP-65 Regulate Pre-B Cell Differentiation and the Induction of Ig Light Chain Gene Rearrangement

2006 ◽  
Vol 176 (8) ◽  
pp. 4543-4552 ◽  
Author(s):  
Rogier Kersseboom ◽  
Van B. T. Ta ◽  
A. J. Esther Zijlstra ◽  
Sabine Middendorp ◽  
Hassan Jumaa ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Tyrosine Kinase ◽  
B Cell ◽  
Light Chain ◽  
Gene Rearrangement ◽  
Chain Gene ◽  
B Cell Differentiation ◽  
Bruton's Tyrosine Kinase ◽  
Light Chain Gene ◽  
Chain Gene Rearrangement

scholarly journals Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B‐cell neoplasms

2019 ◽  
Vol 185 (2) ◽  
pp. 261-265
Author(s):  
Anna L. Paterson ◽  
Hesham El‐Daly ◽  
Livia Raso‐Barnett ◽  
Ming‐Qing Du ◽  
Olivier Giger ◽  
...  
Keyword(s):  
B Cell ◽  
Light Chain ◽  
Gene Rearrangement ◽  
Chain Gene ◽  
Lambda Light Chain ◽  
Light Chain Gene ◽  
Chain Gene Rearrangement ◽  
Gene Rearrangement Analysis ◽  
Immunoglobulin Lambda

scholarly journals The added value of immunoglobulin Kappa light chain gene (IGK) rearrangement analysis in suspected B-cell lymphomas: three illustrative cases

2012 ◽  
Vol 5 (1-2) ◽  
pp. 45-56 ◽  
Author(s):  
Paula Gameiro ◽  
Marta Sebastião ◽  
Signe Spetalen ◽  
Maria Gomes da Silva ◽  
José Cabeçadas
Keyword(s):  
B Cell ◽  
Light Chain ◽  
Added Value ◽  
Chain Gene ◽  
Kappa Light Chain ◽  
B Cell Lymphomas ◽  
Light Chain Gene ◽  
Immunoglobulin Kappa

scholarly journals Immunoglobulin κ Light Chain Gene Rearrangement Is Impaired in Mice Deficient for DNA Polymerase Mu

Immunity ◽  
2003 ◽  
Vol 19 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Barbara Bertocci ◽  
Annie De Smet ◽  
Claudia Berek ◽  
Jean-Claude Weill ◽  
Claude-Agnès Reynaud
Keyword(s):  
Dna Polymerase ◽  
Light Chain ◽  
Gene Rearrangement ◽  
Chain Gene ◽  
Light Chain Gene ◽  
Chain Gene Rearrangement
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