scholarly journals Surface micro and nanostructuring of three-dimensional components of micro medical devices

Procedia CIRP ◽  
2020 ◽  
Vol 95 ◽  
pp. 915-920
Author(s):  
Francesco Biondani ◽  
Lorenzo Benassi ◽  
Giuliano Bissacco ◽  
Leonardo Orazi ◽  
Peter T. Tang
Keyword(s):  
Medical Devices ◽  
Three Dimensional

scholarly journals Transfiguring Healthcare: Three-Dimensional Printing in Pharmaceutical Sciences; Trends during COVID-19: A Review

2021 ◽  
pp. 207-218
Author(s):  
K. G. Siree ◽  
T. M. Amulya ◽  
T. M. Pramod Kumar ◽  
S. Sowmya ◽  
K. Divith ◽  
...  
Keyword(s):  
3D Printing ◽  
Medical Devices ◽  
Three Dimensional ◽  
Pharmaceutical Sciences ◽  
Three Dimensional Printing ◽  
Custom Made ◽  
High Degree ◽  
The Impact ◽  
Dimensional Printing ◽  
Shed Light

Three-dimensional (3D) printing is a unique technique that allows for a high degree of customisation in pharmacy, dentistry and in designing of medical devices. 3D printing satiates the increasing exigency for consumer personalisation in these fields as custom-made medicines catering to the patients’ requirements are novel advancements in drug therapy. Current research in 3D printing indicates towards reproducing an organ in the form of a chip; paving the way for more studies and opportunities to perfecting the existing technique. In addition, we will also attempt to shed light on the impact of 3D printing in the COVID-19 pandemic.

scholarly journals Multiscale three-dimensional surface reconstruction and surface roughness of porcine left anterior descending coronary arteries

2019 ◽  
Vol 6 (9) ◽  
pp. 190915 ◽  
Author(s):  
Hanna E. Burton ◽  
Rachael Cullinan ◽  
Kyle Jiang ◽  
Daniel M. Espino
Keyword(s):  
Surface Roughness ◽  
Coronary Arteries ◽  
Medical Devices ◽  
Ex Vivo ◽  
Three Dimensional ◽  
Force Microscopy ◽  
Optical Scanning ◽  
Atomic Force ◽  
Reconstructed Surface ◽  
Dimensional Surface

The aim of this study was to investigate the multiscale surface roughness characteristics of coronary arteries, to aid in the development of novel biomaterials and bioinspired medical devices. Porcine left anterior descending coronary arteries were dissected ex vivo , and specimens were chemically fixed and dehydrated for testing. Surface roughness was calculated from three-dimensional reconstructed surface images obtained by optical, scanning electron and atomic force microscopy, ranging in magnification from 10× to 5500×. Circumferential surface roughness decreased with magnification, and microscopy type was found to influence surface roughness values. Longitudinal surface roughness was not affected by magnification or microscopy types within the parameters of this study. This study found that coronary arteries exhibit multiscale characteristics. It also highlights the importance of ensuring consistent microscopy parameters to provide comparable surface roughness values.

Methodology for Hemodynamic Assessment of a Three-Dimensional Printed Patient-Specific Vascular Test Device

2019 ◽  
Vol 13 (3) ◽  
Author(s):  
Gavin A. D'Souza ◽  
Michael D. Taylor ◽  
Rupak K. Banerjee
Keyword(s):  
Pressure Drop ◽  
3D Printing ◽  
Medical Devices ◽  
Velocity Ratio ◽  
Three Dimensional ◽  
Patient Specific ◽  
Test Device ◽  
Dimensionless Pressure ◽  
Hemodynamic Assessment ◽  
Stenosis Severity

Assessing hemodynamics in vasculature is important for the development of cardiovascular diagnostic parameters and evaluation of medical devices. Benchtop experiments are a safe and comprehensive preclinical method for testing new diagnostic endpoints and devices within a controlled environment. Recent advances in three-dimensional (3D) printing have enhanced benchtop tests by allowing generation of patient-specific and pathophysiologic conditions. We used 3D printing, coupled with image processing and computer-aided design (CAD), to develop a patient-specific vascular test device from clinical data. The proximal pulmonary artery (PA) tree including the main, left, and right pulmonary arteries, with a stenosis within the left PA was selected as a representative anatomy for developing the vascular test device. Three test devices representing clinically relevant stenosis severities, 90%, 80%, and 70% area stenosis, were evaluated at different cardiac outputs (COs). A mock circulatory loop (MCL) generating pathophysiologic pulmonary pressure and flow was used to evaluate the hemodynamics within the devices. The dimensionless pressure drop–velocity ratio characteristic curves for the three stenosis severities were obtained. At a fixed CO, the dimensionless pressure drop increased nonlinearly with an increase in (a) the velocity ratio for a fixed stenosis severity and (b) the stenosis severity at a specific velocity ratio. The dimensionless pressure drop observed in vivo was similar (within 1%) to that measured in moderate area stenosis of 70% because both flows were viscous dominated. The hemodynamics of the 3D printed test device can be used for evaluating diagnostic endpoints and medical devices in a preclinical setting under realistic conditions.

Near-Field Inductive-Coupling Link to Power a Three-Dimensional Millimeter-Size Antenna for Brain Implantable Medical Devices

2018 ◽  
Vol 65 (1) ◽  
pp. 4-14 ◽  
Author(s):  
Mohamed Manoufali ◽  
Konstanty Bialkowski ◽  
Beadaa Jasem Mohammed ◽  
Paul C. Mills ◽  
Amin Abbosh
Keyword(s):  
Medical Devices ◽  
Near Field ◽  
Three Dimensional ◽  
Inductive Coupling ◽  
Implantable Medical Devices

scholarly journals Finite Element Modeling of Surgical Scalpel with Piezoelectric Actuator

2019 ◽  
pp. 15-23
Author(s):  
A. S. Skaliukh ◽  
P. A. Oganesyan ◽  
A. A. Solovieva ◽  
T. E. Gerasimenko
Keyword(s):  
Finite Element ◽  
Finite Element Modeling ◽  
Medical Devices ◽  
Numerical Experiments ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Theory Of Elasticity ◽  
Element Modeling ◽  
Oscillatory Systems ◽  
Viscosity Coefficients

The main goal of the present work is mathematical and finite element modeling of component dynamic oscillatory systems, including piezoceramic elements, elastic elements and external influences from soft tissues that describe the operation of ultrasonic medical devices, as applied to instruments and medical devices for finding the most effective forms and modes of operation. Elastic and piezoceramic solids are modeled within the linear theory of elasticity and electroelasticity, and soft tissues are acoustically medium with certain viscosity coefficients. As a research tool used CAE package ACELAN, which builds three-dimensional and axisymmetric models of the device. In numerical experiments, a modal and harmonic analysis is performed, on the basis of which the most effective operating frequencies are identified.

scholarly journals A Project Course Sequence in Innovation and Commercialization of Medical Devices

2017 ◽  
Vol 139 (7) ◽  
Author(s):  
Alan W. Eberhardt ◽  
Shea Tillman ◽  
Brandon Kirkland ◽  
Brandon Sherrod
Keyword(s):  
Medical Devices ◽  
Printed Circuit Boards ◽  
Local Community ◽  
Three Dimensional ◽  
Lessons Learned ◽  
University Hospital ◽  
First Semester ◽  
Design Concepts ◽  
Course Sequence ◽  
Assessment Results

There exists a need for educational processes in which students gain experience with design and commercialization of medical devices. This manuscript describes the implementation of, and assessment results from, the first year offering of a project course sequence in Master of Engineering (MEng) in Design and Commercialization at our institution. The three-semester course sequence focused on developing and applying hands-on skills that contribute to product development to address medical device needs found within our university hospital and local community. The first semester integrated computer-aided drawing (CAD) as preparation for manufacturing of device-related components (hand machining, computer numeric control (CNC), three-dimensional (3D) printing, and plastics molding), followed by an introduction to microcontrollers (MCUs) and printed circuit boards (PCBs) for associated electronics and control systems. In the second semester, the students applied these skills on a unified project, working together to construct and test multiple weighing scales for wheelchair users. In the final semester, the students applied industrial design concepts to four distinct device designs, including user and context reassessment, human factors (functional and aesthetic) design refinement, and advanced visualization for commercialization. The assessment results are described, along with lessons learned and plans for enhancement of the course sequence.

Regulating 3D-printed medical products

2018 ◽  
Vol 10 (461) ◽  
pp. eaan6521 ◽  
Author(s):  
Laura M. Ricles ◽  
James C. Coburn ◽  
Matthew Di Prima ◽  
Steven S. Oh
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Medical Devices ◽  
Three Dimensional ◽  
Emerging Technology ◽  
3D Object ◽  
Medical Products ◽  
3D Printed ◽  
Regulatory Landscape ◽  
The U.S

Additive manufacturing [also known as three-dimensional (3D) printing] is the layer-wise deposition of material to produce a 3D object. This rapidly emerging technology has the potential to produce new medical products with unprecedented structural and functional designs. Here, we describe the U.S. regulatory landscape of additive manufactured (3D-printed) medical devices and biologics and highlight key challenges and considerations.

Three Dimensional Medical Images

2011 ◽  
pp. 287-293
Author(s):  
Efstratios Poravas ◽  
Nikolaos Giannakakis ◽  
Dimitra Petroudi
Keyword(s):  
Medical Devices ◽  
Medical Images ◽  
Three Dimensional ◽  
Annual Budget ◽  
Analysis Of The Images ◽  
The Revolution

The revolution of technology has lead to a change; from the analogic to the digital function of medical devices. Some of them were produced in the last years to improve the quality of images. Although the procedure of acquiring and using the devices has been very complicated, the analysis of the images is so dependable that a big amount of the annual budget is spent for their acquisition.

scholarly journals Three-Dimensional Printed PCL-Based Implantable Prototypes of Medical Devices for Controlled Drug Delivery

2016 ◽  
Vol 105 (9) ◽  
pp. 2665-2676 ◽  
Author(s):  
Jenny Holländer ◽  
Natalja Genina ◽  
Harri Jukarainen ◽  
Mohammad Khajeheian ◽  
Ari Rosling ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Medical Devices ◽  
Three Dimensional ◽  
Controlled Drug Delivery

scholarly journals MRI–Compatible Fluid-Powered Medical Devices

2013 ◽  
Vol 135 (06) ◽  
pp. S13-S16 ◽  
Author(s):  
Jun Ueda ◽  
David B. Comber ◽  
Jonathon Slightam ◽  
Melih Turkseven ◽  
Vito Gervasi ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Medical Devices ◽  
Imaging Techniques ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Recent Developments ◽  
Mri Environment ◽  
Magnetic Resonance Imaging Mri ◽  
End Use ◽  
Future Work

This article introduces recent developments and challenges related to magnetic resonance imaging (MRI)-compatible medical devices. Recent advances in fluid-powered medical devices are described, including a needle steering robot for neurosurgery and a haptic device for hemiplegia rehabilitation. Recent three-dimensional printing technologies for fabricating integrated fluid-powered robots are also reported. The use of additive manufacturing conjoined with modern digital imaging techniques allow for the customization of components, a trait that is generally needed in medical implants and devices. Furthermore, the materials that are available in additive processes allow for direct end-use production of customized components and devices. In addition, the polymer-based materials have an inherently low permeability, allowing for use in an MRI environment while not causing imaging interference. Presently, selective laser sintering (SLS), stereolithography, and extrusion processes illustrate and suggest that they offer the greatest promise in MRI compatible end-use components. Future work is aimed at using Additive Manufacturing (AM) to develop inherently safe, compact, MRI compatible medical devices.

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