Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying

2017 ◽  
Vol 305 ◽  
pp. 63-70 ◽  
Author(s):  
Tiantian Ye ◽  
Jiaqi Yu ◽  
Qiuhua Luo ◽  
Shujun Wang ◽  
Hak-Kim Chan
Keyword(s):  
Freeze Drying ◽  
Dry Powders ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

scholarly journals Evaluation of Process Conditions for Ultrasonic Spray-Freeze Drying of Transglutaminase

2020 ◽  
Vol 58 (1) ◽  
pp. 38-48
Author(s):  
Hilal Isleroglu ◽  
Izzet Turker
Keyword(s):  
Enzyme Activity ◽  
Flow Rate ◽  
Freeze Drying ◽  
Desirability Function ◽  
Spherical Particles ◽  
Optimum Process ◽  
Process Conditions ◽  
Plate Temperature ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

In this study, a commercial transglutaminase enzyme was dried using an ultrasonic spray freeze drying method and the effects of the process conditions were optimized to maximize the final transglutaminase activity. Accordingly, process parameters affecting enzyme activity were selected, such as nozzle frequency (48 and 120 kHz), flow rate (2, 5 and 8 mL/min) and plate temperature for secondary drying (25, 35 and 45 °C). Moreover, the effects of different pH values (pH=2.0 and 9.0) and high temperature (80 °C) on enzyme activity, physical properties and particle morphology of transglutaminase were discussed. According to the results, transglutaminase preserved its activity despite ultrasonic spray freeze drying. Sonication enhanced the enzyme activity. Using the desirability function method, the optimum process conditions were determined to be flow rate 3.10 mL/min, plate temperature 45 °C and nozzle frequency 120 kHz. The predicted activity ratio was 1.17, and experimentally obtained ratio was 1.14±0.02. Furthermore, enzyme produced by ultrasonic spray freeze drying had low moisture values (2.92-4.36 %) at 8 h of drying. When the morphological structure of the transglutaminase particles produced by ultrasonic spray freeze drying under the optimum conditions was examined, spherical particles with pores on their surfaces were observed. In addition, flow properties of the transglutaminase powders were considered as fair under most conditions according to the Carr index.

Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying

2013 ◽  
Vol 30 (11) ◽  
pp. 2891-2901 ◽  
Author(s):  
Suzanne M. D’Addio ◽  
John Gar Yan Chan ◽  
Philip Chi Lip Kwok ◽  
Bryan R. Benson ◽  
Robert K. Prud’homme ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Aerosol Delivery ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

scholarly journals The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process

2016 ◽  
Vol 66 (2) ◽  
pp. 207-218 ◽  
Author(s):  
Narges Poursina ◽  
Alireza Vatanara ◽  
Mohammad Reza Rouini ◽  
Kambiz Gilani ◽  
Abdolhossein Rouholamini Najafabadi
Keyword(s):  
Salmon Calcitonin ◽  
Freeze Drying ◽  
Tween 80 ◽  
Drying Process ◽  
Dry Powders ◽  
Aerosol Performance ◽  
Inhalation Delivery ◽  
Spray Freeze Drying ◽  
The Stability ◽  
Structurally Stable

Abstract Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on the aerosol performance of the particles were investigated. The results indicated that hydroxyl propyl-β-cyclodextrin had the most important effect on the chemical stability of the powder and strongly increased its stability by increasing its concentration in the formulation. Chemically stable formulations (over 90 % recovery) were selected for further examinations. Fluorescence spectroscopy and circular dichroism suggested that the formulations were structurally stable. Aerosol performance showed that the Tween-free powders produced higher fine particle fraction values than the formulations containing Tween (53.7 vs. 41.92 % for trehalose content and 52.85 vs. 43.06 % for maltose content).

Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition

2019 ◽  
Vol 560 ◽  
pp. 144-154 ◽  
Author(s):  
Qiuying Liao ◽  
Long Yip ◽  
Michael Y.T. Chow ◽  
Shing Fung Chow ◽  
Hak-Kim Chan ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Pulmonary Delivery ◽  
Lung Deposition ◽  
Dry Powders ◽  
Spray Freeze Drying

Microstructure of spray freezing dried powders affected by the presence of inert particles

2020 ◽  
Vol 16 (7) ◽  
Author(s):  
Fan Zhang ◽  
Linsong Wang ◽  
Xiaoyu Ma ◽  
Qing Xu ◽  
Wei Tian ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Great Influence ◽  
Freezing Process ◽  
Drying Time ◽  
Dry Powders ◽  
Spray Freezing ◽  
Spray Freeze Drying ◽  
The Difference ◽  
Droplet Morphology ◽  
Drying Chamber

AbstractSpray freeze-drying is a process to directly produce high quality powders with short drying time. The difference of microstructures has a great influence on the physical properties of powders. However, during the spray freeze-drying process, the freezing degree of droplets in the drying chamber will change the product structure and affect the powder quality. In this study, the surface structure and morphology of dry powders were observed using scanning electron microscopy. The formation mechanism of droplet morphology during spray freeze-drying was analyzed. The results show that the rapid freezing process can produce finer microstructures.

Sinterability of Yttria-Stabilized Zirconia Powder Prepared by Ultrasonic Spray Freeze-Drying Technique

1994 ◽  
Vol 9 (4) ◽  
pp. 666-679 ◽  
Author(s):  
Shinji Iwaida ◽  
Kiyoshi Itatani ◽  
F. Scott Howell ◽  
Akira Kishioka ◽  
Makio Kinoshita
Keyword(s):  
Freeze Drying ◽  
Yttria Stabilized Zirconia ◽  
Stabilized Zirconia ◽  
Zirconia Powder ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

Microencapsulation of Microbial Transglutaminase by Ultrasonic Spray-Freeze Drying

2019 ◽  
Vol 12 (12) ◽  
pp. 2004-2017 ◽  
Author(s):  
Hilal Isleroglu ◽  
Izzet Turker ◽  
Banu Koc ◽  
Mehmet Tokatli
Keyword(s):  
Freeze Drying ◽  
Microbial Transglutaminase ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying
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