Polymers' ultrafine particles for drug delivery systems precipitated by supercritical carbon dioxide + organic solvent mixtures

2016 ◽  
Vol 292 ◽  
pp. 140-148 ◽  
Author(s):  
Valentina Prosapio ◽  
Ernesto Reverchon ◽  
Iolanda De Marco
Keyword(s):  
Carbon Dioxide ◽  
Drug Delivery ◽  
Supercritical Carbon Dioxide ◽  
Organic Solvent ◽  
Ultrafine Particles ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Solvent Mixtures ◽  
Supercritical Carbon

Characterization of drug delivery particles produced by supercritical carbon dioxide technologies

2017 ◽  
Vol 128 ◽  
pp. 244-262 ◽  
Author(s):  
Onanong Nuchuchua ◽  
M. Reza Nejadnik ◽  
Sebastiaan C. Goulooze ◽  
Nataša Jovanović Lješković ◽  
Hayley A. Every ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Drug Delivery ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Carbon

Putting the fizz into chemistry: applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers

2007 ◽  
Vol 35 (3) ◽  
pp. 516-521 ◽  
Author(s):  
H. Tai ◽  
V.K. Popov ◽  
K.M. Shakesheff ◽  
S.M. Howdle
Keyword(s):  
Carbon Dioxide ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Block Copolymers ◽  
Supercritical Carbon Dioxide ◽  
Drug Carriers ◽  
Controlled Polymerization ◽  
Polymeric Scaffolds ◽  
Potential Use ◽  
Supercritical Carbon

This paper describes the recent progress at Nottingham towards the exploitation of the unique properties of scCO2 (supercritical carbon dioxide) for the preparation of polymeric scaffolds for tissue engineering applications and new devices for controlled drug delivery, as well as the synthesis of novel block copolymers by the combination of eROP (enzymatic ring opening polymerization) and controlled polymerization methods for the potential use as drug carriers.

scholarly journals Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1928
Author(s):  
Heejun Park ◽  
Jeong-Soo Kim ◽  
Sebin Kim ◽  
Eun-Sol Ha ◽  
Min-Soo Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Organic Solvent ◽  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Drug Delivery Systems ◽  
Active Material ◽  
Delivery Systems ◽  
Water Soluble ◽  
Fluid Extraction ◽  
Pharmaceutical Applications

Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the various micro-/nanoparticle production technologies, emulsion-based particle formation is the most widely used because of its unique advantages such as uniform generation of spherical small particles and higher encapsulation efficiency (EE). For this emulsion-based micro-/nanoparticle technology, one of the most important factors is the extraction efficiency associated with the fast removal of the organic solvent. In consideration of this, a technology called supercritical fluid extraction of emulsions (SFEE) that uses the unique mass transfer mechanism and solvent power of a supercritical fluid (SCF) has been proposed to overcome the shortcomings of several conventional technologies such as solvent evaporation, extraction, and spray drying. This review article presents the main aspects of SFEE technology for the preparation of micro-/nanoparticles by focusing on its pharmaceutical applications, which have been organized and classified according to several types of drug delivery systems and active pharmaceutical ingredients. It was definitely confirmed that SFEE can be applied in a variety of drugs from water-soluble to poorly water-soluble. In addition, it has advantages such as low organic solvent residual, high EE, desirable release control, better particle size control, and agglomeration prevention through efficient and fast solvent removal compared to conventional micro-/nanoparticle technologies. Therefore, this review will be a good resource for determining the applicability of SFEE to obtain better pharmaceutical quality when researchers in related fields want to select a suitable manufacturing process for preparing desired micro-/nanoparticle drug delivery systems containing their active material.

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