Dispersion polymerization of vinyl monomers in supercritical carbon dioxide in the presence of drug molecules: A one-pot route for the preparation of controlled delivery systems

2008 ◽  
Vol 46 (22) ◽  
pp. 7429-7446 ◽  
Author(s):  
Alessandro Galia ◽  
Onofrio Scialdone ◽  
Gianpiero Ferraro ◽  
Giuseppe Filardo
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Dispersion Polymerization ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Vinyl Monomers ◽  
One Pot ◽  
Drug Molecules ◽  
Supercritical Carbon

scholarly journals Dispersion Polymerization of Vinyl Monomers in Supercritical Carbon Dioxide

2002 ◽  
Vol 75 (8) ◽  
pp. 371-377 ◽  
Author(s):  
Masanori KOBAYASHI ◽  
Katsunobu MIZUGUCHI ◽  
Hideki SAKAI ◽  
Masahiko ABE ◽  
Katsuto OTAKE
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Dispersion Polymerization ◽  
Vinyl Monomers ◽  
Supercritical Carbon

scholarly journals Impregnation of poly(L-lactide-ran-δ-valerolactone) with essential bark oil using supercritical carbon dioxide

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chikara Tsutsumi ◽  
Souta Manabe ◽  
Susumu Nakayama ◽  
Yuushou Nakayama ◽  
Takeshi Shiono
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Azeotropic Distillation ◽  
Proteinase K ◽  
High Yield ◽  
Feed Ratio ◽  
One Pot ◽  
Molecular Weights ◽  
Hydrolysis Process ◽  
Supercritical Carbon

Abstract This work studied the incorporation of essential bark oil from Thujopsis dolabrata var. hondae, which is known to repel various insects, in poly(L-lactide-ran-δ-valerolactone) [poly(L-LA-ran-VL)] using supercritical carbon dioxide (scCO2). The poly(L-LA-ran-VL) was synthesized by first purifying the monomers by azeotropic distillation with benzene, followed by polymerization with Sn(oct)2 using the same equipment, representing an efficient one-pot process. The copolymerization of L-LA with VL using this technique at a feed ratio of 90/10 mol/mol gave poly(L-LA-ran-VL) (91/9) with a molecular weight of 6.48 × 104 g/mol and a high yield of 74.9%. Products with molecular weights over 5.0 × 104 g/mol were obtained at L-LA feed proportions of 70 to 90%. Impregnation trials were conducted between 40 and 120 °C at 14 MPa for 3 h. The oil content of a 73/27 specimen was found to increase significantly during processing at 100 or 120 °C. During enzymatic degradation with proteinase K, the 91/9 specimen showed the fastest degradation rate. Although the 71/29 sample was slowly hydrolyzed in a phosphate buffer at pH 7.0, the release of oil vapor from this material was slightly higher than that from the 91/9 specimen, and the vapor release rate continuously increased throughout the hydrolysis process.

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