3D printed polylactic acid nanocomposite scaffolds for tissue engineering applications

2020 ◽  
Vol 81 ◽  
pp. 106203 ◽  
Author(s):  
Fahad Alam ◽  
K.M. Varadarajan ◽  
S. Kumar
Keyword(s):  
Tissue Engineering ◽  
Polylactic Acid ◽  
Engineering Applications ◽  
3D Printed ◽  
Nanocomposite Scaffolds

scholarly journals Development of 3D-printed PLGA/TiO2 nanocomposite scaffolds for bone tissue engineering applications

2019 ◽  
Vol 96 ◽  
pp. 105-113 ◽  
Author(s):  
M. Rasoulianboroujeni ◽  
F. Fahimipour ◽  
P. Shah ◽  
K. Khoshroo ◽  
M. Tahriri ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
3D Printed ◽  
Nanocomposite Scaffolds

scholarly journals Evaluation of synovium-derived mesenchymal stem cells and 3D printed nanocomposite scaffolds for tissue engineering

2015 ◽  
Vol 16 (4) ◽  
pp. 045001 ◽  
Author(s):  
Jian-Feng Pan ◽  
Shuo Li ◽  
Chang-An Guo ◽  
Du-Liang Xu ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
3D Printed ◽  
Nanocomposite Scaffolds

Biomimetic TiO2-chitosan/sodium alginate blended nanocomposite scaffolds for tissue engineering applications

2020 ◽  
Vol 110 ◽  
pp. 110710 ◽  
Author(s):  
Balu Kolathupalayam Shanmugam ◽  
Suriyaprabha Rangaraj ◽  
Karthik Subramani ◽  
Surendhiran Srinivasan ◽  
Wilhelm K. Aicher ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Sodium Alginate ◽  
Engineering Applications ◽  
Nanocomposite Scaffolds

scholarly journals Alginate/Gelatin Hydrogels Reinforced with TiO2 and β-TCP Fabricated by Microextrusion-based Printing for Tissue Regeneration

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 457 ◽  
Author(s):  
Rodrigo Urruela-Barrios ◽  
Erick Ramírez-Cedillo ◽  
A. Díaz de León ◽  
Alejandro Alvarez ◽  
Wendy Ortega-Lara
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Average Pore Size ◽  
Three Dimensional ◽  
Engineering Applications ◽  
Average Pore ◽  
Viscous Deformation ◽  
Freeze Dried ◽  
3D Printed

Three-dimensional (3D) printing technologies have become an attractive manufacturing process to fabricate scaffolds in tissue engineering. Recent research has focused on the fabrication of alginate complex shaped structures that closely mimic biological organs or tissues. Alginates can be effectively manufactured into porous three-dimensional networks for tissue engineering applications. However, the structure, mechanical properties, and shape fidelity of 3D-printed alginate hydrogels used for preparing tissue-engineered scaffolds is difficult to control. In this work, the use of alginate/gelatin hydrogels reinforced with TiO2 and β-tricalcium phosphate was studied to tailor the mechanical properties of 3D-printed hydrogels. The hydrogels reinforced with TiO2 and β-TCP showed enhanced mechanical properties up to 20 MPa of elastic modulus. Furthermore, the pores of the crosslinked printed structures were measured with an average pore size of 200 μm. Additionally, it was found that as more layers of the design were printed, there was an increase of the line width of the bottom layers due to its viscous deformation. Shrinkage of the design when the hydrogel is crosslinked and freeze dried was also measured and found to be up to 27% from the printed design. Overall, the proposed approach enabled fabrication of 3D-printed alginate scaffolds with adequate physical properties for tissue engineering applications.

scholarly journals Fabrication of 3D printed antimicrobial polycaprolactone scaffolds for tissue engineering applications

2021 ◽  
Vol 118 ◽  
pp. 111525 ◽  
Author(s):  
Socrates Radhakrishnan ◽  
Sakthivel Nagarajan ◽  
Habib Belaid ◽  
Cynthia Farha ◽  
Igor Iatsunskyi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Engineering Applications ◽  
3D Printed

scholarly journals Three-dimensional Printed Polylactic Acid and Hydroxyapatite Composite Scaffold with Urine-derived Stem Cells Treatment for Bone Defects

2021 ◽  
Author(s):  
Xiang Zhang ◽  
Jialei Chen ◽  
Hongren Wang ◽  
Xin Duan ◽  
Feng Gao
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Composite Scaffold ◽  
Bone Defects ◽  
Skull Defect ◽  
Defect Area ◽  
3D Printed

Abstract BACKGROUND: Bone defects still pose various challenges in osteology. As one of the treatment options for bone defects, bone tissue engineering requires biomaterials with good biocompatibility and seed cells with good differentiation capacity. This study aimed to fabricate a 3D-printed polylactic acid and hydroxyapatite (PLA/HA) composite scaffold with urine-derived stem cells (USCs) to study its therapeutic effect in a model of skull defect in rats.METHODS: USCs, isolated and extracted from the urine of healthy adult males, were inoculated onto a 3D-printed PLA/HA composite scaffold and a PLA scaffold. Skull defect model rats were randomly divided into three groups (control, PLA, and PLA/HA). Twelve weeks after implanting scaffolds containing USCs into rats with a skull defect, the therapeutic efficacy was evaluated by real-time PCR, micro-CT, histology, and immunohistochemistry.RESULTS: The 3D-printed PLA/HA composite scaffold had good mechanical properties and porosity. The adhesion and proliferation of USCs on scaffolds also demonstrated excellent biocompatibility. PLA and PLA/HA containing USCs promoted bone regeneration in the defect area, supported by the general observation and CT images at 12 weeks after treatment, with coverage of 74.6%±1.9% and 96.7%±1.6%, respectively. Immunohistochemical staining showed a progressive process of new bone formation on PLA/HA scaffolds containing USCs at the defect site compared to that in PLA and control groups.CONCLUSION: The 3D-printed PLA/HA composite scaffold with USCs was successfully applied to the skull defect in rats. Under the linkage of the scaffold, the proliferation, differentiation, and osteogenesis expression of USCs were promoted near the bone defect area. These findings demonstrated broad application prospects of PLA/HA scaffolds with USCs in bone tissue engineering.

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