Acid-labile poly(ortho ester amino alcohols) by ring-opening polymerization for controlled DNA release and improved serum tolerance

Polymer ◽  
2016 ◽  
Vol 96 ◽  
pp. 146-155 ◽  
Author(s):  
Min Yu ◽  
Lei Zhang ◽  
Jun Wang ◽  
Rupei Tang ◽  
Guoqing Yan ◽  
...  
Keyword(s):  
Ring Opening ◽  
Amino Alcohols ◽  
Ring Opening Polymerization ◽  
Ortho Ester ◽  
Dna Release ◽  
Acid Labile

scholarly journals Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery

2018 ◽  
Vol 30 (34) ◽  
pp. 1801151 ◽  
Author(s):  
Piotr S. Kowalski ◽  
Umberto Capasso Palmiero ◽  
Yuxuan Huang ◽  
Arnab Rudra ◽  
Robert Langer ◽  
...  
Keyword(s):  
Ring Opening ◽  
Amino Alcohols ◽  
Ring Opening Polymerization ◽  
Tertiary Amino

A Recommender System for Inverse Design of Polycarbonates and Polyesters

2020 ◽  
Author(s):  
Nathaniel Park ◽  
Dmitry Yu. Zubarev ◽  
James L. Hedrick ◽  
Vivien Kiyek ◽  
Christiaan Corbet ◽  
...  
Keyword(s):  
Ring Opening ◽  
High Performance ◽  
Recommendation System ◽  
Polymeric Materials ◽  
Monomer Conversion ◽  
Design Strategy ◽  
Ring Opening Polymerization ◽  
Inverse Design ◽  
False Negatives ◽  
Accelerate Development

The convergence of artificial intelligence and machine learning with material science holds significant promise to rapidly accelerate development timelines of new high-performance polymeric materials. Within this context, we report an inverse design strategy for polycarbonate and polyester discovery based on a recommendation system that proposes polymerization experiments that are likely to produce materials with targeted properties. Following recommendations of the system driven by the historical ring-opening polymerization results, we carried out experiments targeting specific ranges of monomer conversion and dispersity of the polymers obtained from cyclic lactones and carbonates. The results of the experiments were in close agreement with the recommendation targets with few false negatives or positives obtained for each class.<br>

Bisurea and Bisthiourea H-Bonding Organocatalysts for Ring-Opening Polymerization: Cues for the Catalyst Design

2019 ◽  
Vol 52 (23) ◽  
pp. 9232-9237 ◽  
Author(s):  
Rukshika S. Hewawasam ◽  
U. L. D. Inush Kalana ◽  
Nayanthara U. Dharmaratne ◽  
Thomas J. Wright ◽  
Timothy J. Bannin ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Catalyst Design

scholarly journals Controlled Ring-Opening Polymerization of O-Carboxyanhydrides to Synthesize Functionalized Poly(α-Hydroxy Acids)

2021 ◽  
Vol 03 (01) ◽  
pp. 041-050
Author(s):  
Xiaoqian Wang ◽  
Ai Lin Chin ◽  
Rong Tong
Keyword(s):  
Biomedical Engineering ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Metal Catalyst ◽  
Hydroxy Acids ◽  
Controlled Polymerization ◽  
Biodegradable Polyesters ◽  
Recent Advances

Poly(α-hydroxy acids), as a family of biodegradable polyesters, are valuable materials due to their broad applications in packaging, agriculture, and biomedical engineering. Herein we highlight and explore recent advances of catalysts in controlled ring-opening polymerization of O-carboxyanhydrides towards functionalized poly(α-hydroxy acids), especially metal catalyst-mediated controlled polymerization. Limitations of current polymerization strategies of O-carboxyanhydrides are discussed.

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