Synthesis of amphiphilic macrocyclic graft copolymer consisting of a poly(ethylene oxide) ring and multi-poly(ɛ-caprolactone) lateral chains

Polymer ◽  
2008 ◽  
Vol 49 (4) ◽  
pp. 893-900 ◽  
Author(s):  
Xinchang Pang ◽  
Rongkuan Jing ◽  
Junlian Huang
Keyword(s):  
Ethylene Oxide ◽  
Graft Copolymer ◽  
Oxide Ring ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

scholarly journals Ultra-large sheet formation by 1D to 2D hierarchical self-assembly of a “rod–coil” graft copolymer with a polyphenylene backbone

2016 ◽  
Vol 7 (6) ◽  
pp. 1234-1238 ◽  
Author(s):  
Yinjuan Huang ◽  
Rui Yuan ◽  
Fugui Xu ◽  
Yiyong Mai ◽  
Xinliang Feng ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Graft Copolymer ◽  
Self Assembly ◽  
Side Chains ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Large Sheet

This study presents a unique ultra-large sheet formation through 1D to 2D hierarchical self-assembly of a rod–coil graft copolymer containing a rigid polyphenylene backbone tethered with flexible poly(ethylene oxide) side chains.

Emulsion Polymerisation of St/BuA Stabilised with a PEG-containing Graft Copolymer

2008 ◽  
Vol 16 (9) ◽  
pp. 635-639 ◽  
Author(s):  
Linlin Guo ◽  
Ge Gao ◽  
Xiaoli Liu ◽  
Fengqi Liu
Keyword(s):  
Ethylene Oxide ◽  
Graft Copolymer ◽  
Polystyrene Microspheres ◽  
Amphiphilic Graft Copolymer ◽  
In Situ Reaction ◽  
Emulsion Polymerisation ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

An amphiphilic graft copolymer comprising poly(ethylene oxide) (PEG) grafts was synthesised and characterised. It was used to stabilise the emulsion polymerisation of St or BuA. The effectiveness of this PEG-containing graft copolymer in stabilising St/BuA emulsion polymerisation was studied. Finally, stable dispersions of polystyrene microspheres were used as templates, and polystyrene microspheres were coated with Fe3O4 by in situ reaction of Fe3+ and Fe2+ in the presence of OH−. No additional treatments were needed in the process.

A comparison of covalent and noncovalent strategies for paclitaxel release using poly(ester amide) graft copolymer micelles

2015 ◽  
Vol 93 (4) ◽  
pp. 399-405 ◽  
Author(s):  
Abdolrasoul Soleimani ◽  
Mahmoud M. Abd Rabo Moustafa ◽  
Aneta Borecki ◽  
Elizabeth R. Gillies
Keyword(s):  
Ethylene Oxide ◽  
Graft Copolymer ◽  
Drug Carriers ◽  
Prolonged Release ◽  
Amphiphilic Copolymers ◽  
Release Rates ◽  
Drug Molecules ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Micelles formed from amphiphilic copolymers are promising for the delivery of drug molecules, potentially leading to enhanced properties and efficacies. Critical aspects of these systems include the use of biocompatible, biodegradable polymer backbones as well as the ability to control the incorporation of drugs and their release rates. In this work, a poly(ester amide)–poly(ethylene oxide) graft copolymer with paclitaxel conjugated via ester linkages was prepared and assembled into micelles. For comparison, micelles with physically encapsulated paclitaxel were also prepared. The release rates of these two systems were studied, and the micelles with covalently conjugated paclitaxel exhibited a prolonged release of the drug in comparison to the noncovalent system, which rapidly released the payload. In vitro studies suggested that the poly(ester amide)–poly(ethylene oxide) copolymers were nontoxic, whereas the toxicities of the drug-loaded micelles were dependent on their release rates. Overall, these systems are promising for further development as anticancer drug carriers.

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