scholarly journals Solution equilibrium studies of anticancer ruthenium(II)-η6-p-cymene complexes of pyridinecarboxylic acids

Polyhedron ◽  
2014 ◽  
Vol 67 ◽  
pp. 51-58 ◽  
Author(s):  
Éva Sija ◽  
Christian G. Hartinger ◽  
Bernhard K. Keppler ◽  
Tamás Kiss ◽  
Éva A. Enyedy
Keyword(s):  
Equilibrium Studies ◽  
Solution Equilibrium ◽  
Pyridinecarboxylic Acids

scholarly journals Interaction of Imidazole Containing Hydroxamic Acids with Fe(III): Hydroxamate Versus Imidazole Coordination of the Ligands

2007 ◽  
Vol 2007 ◽  
pp. 1-8 ◽  
Author(s):  
Etelka Farkas ◽  
Dávid Bátka ◽  
Hajnalka Csóka ◽  
Nóra V. Nagy
Keyword(s):  
Metal Ion ◽  
Hydroxamic Acids ◽  
Acetohydroxamic Acid ◽  
Equilibrium Studies ◽  
Solution Equilibrium ◽  
Mononuclear Complexes ◽  
Bonding Interaction ◽  
Uv Visible ◽  
Nmr Methods ◽  
Protonated Molecules

Solution equilibrium studies on Fe(III) complexes formed with imidazole-4-carbohydroxamic acid (Im-4-Cha), N-Me-imidazole-4-carbohydroxamic acid (N-Me-Im-4-Cha), imidazole-4-acetohydroxamic acid (Im-4-Aha), and histidinehydroxamic acid (Hisha) have been performed by using pH-potentiometry, UV-visible spectrophotometry, EPR, ESI-MS, andH-NMR methods. All of the obtained results demonstrate that the imidazole moiety is able to play an important role very often in the interaction with Fe(III), even if this metal ion prefers the hydroxamate chelates very much. If the imidazole moiety is inα-position to the hydroxamic one (Im-4-Cha and N-Me-Im-4-Cha) its coordination to the metal ion is indicated unambiguously by our results. Interestingly, parallel formation of (Nimidazole,Ohydroxamate), and (Ohydroxamate,Ohydroxamate) type chelates seems probable with N-Me-Im-4-Cha. The imidazole is inβ-position to the hydroxamic moiety in Im-4-Aha and an intermolecular noncovalent (mainly H-bonding) interaction seems to organize the intermediate-protonated molecules in this system. Following the formation of mono- and bishydroxamato mononuclear complexes, only EPR silent species exists in the Fe(III)-Hisha system above pH 4, what suggests the rather significant “assembler activity” of the imidazole (perhaps together with the ammonium moiety).

Solution equilibrium studies on anticancer ruthenium(II)–η6-p-cymene complexes of 3-hydroxy-2(1H)-pyridones

2013 ◽  
Vol 734 ◽  
pp. 38-44 ◽  
Author(s):  
Éva A. Enyedy ◽  
Gabriella M. Bognár ◽  
Tamás Kiss ◽  
Muhammad Hanif ◽  
Christian G. Hartinger
Keyword(s):  
Equilibrium Studies ◽  
Solution Equilibrium

scholarly journals Comparative solution equilibrium studies of antitumor ruthenium(η6-p-cymene) and rhodium(η5-C5Me5) complexes of 8-hydroxyquinolines

2017 ◽  
Vol 46 (13) ◽  
pp. 4382-4396 ◽  
Author(s):  
Orsolya Dömötör ◽  
Veronika F. S. Pape ◽  
Nóra V. May ◽  
Gergely Szakács ◽  
Éva A. Enyedy
Keyword(s):  
Multidrug Resistance ◽  
Chloride Ion ◽  
Solution Stability ◽  
Equilibrium Studies ◽  
Solution Equilibrium ◽  
Half Sandwich

Solution stability, chloride ion affinity and multidrug resistance selectivity of half-sandwich Rh(η5-C5Me5) and Ru(η6-p-cymene) complexes of 8-hydroxyquinolines.

Preparation of 2- and 4-substituted 3-hydroxy-5-methylfurans and the aluminum and gallium complexes of 3-hydroxy-5-methyl-2-(N-methylformamido)furan

1994 ◽  
Vol 72 (5) ◽  
pp. 1362-1369 ◽  
Author(s):  
T.G. Lutz ◽  
D.J. Clevette ◽  
H.R. Hoveyda ◽  
V. Karunaratne ◽  
A. Nordin ◽  
...  
Keyword(s):  
Solid State ◽  
Formation Constants ◽  
Mixed Ligand ◽  
Complexing Agent ◽  
Equilibrium Studies ◽  
Solution Equilibrium ◽  
Model Studies ◽  
Solution Studies ◽  
Ligand Species ◽  
Potentiometric Data

In model studies designed to study the synthesis of potentially hexadentate chelates based on the linkage of three furan rings to a triamine via amide linkages, new 2- and 4-substituted 3-hydroxy-5-methylfurans have been prepared. Particularly, 3-hydroxy-5-methyl-(N-methylformamido)furan (Hahm) and its Al and Ga complexes (M(ahm)3) have been prepared and thoroughly characterized by a variety of techniques, in the solid state and in solution. Solution equilibrium studies (μ = 0.6 M NaCl, 25 °C) uncovered a complicated set of equilibria in the Al3+/Hahm system; the solution potentiometric data were best explained by the presence of mixed ligand (HL = Hahm, L− = ahm−) hydroxo species [Al3(OH)4L3]2+ and [Al(OH)2L2]−, in addition to the expected [AlLn](3−n)+ (n = 1, 2, 3) species. Further solution studies at HL:M ratios of 3:1 (μ = 0.15 M NaCl, 25 °C) showed that Hahm is a relatively weak complexing agent for both Al and Ga, forming tris-ligand species with overall formation constants of 1019.5 and 1020.6, respectively.

scholarly journals Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands

2012 ◽  
Vol 117 ◽  
pp. 189-197 ◽  
Author(s):  
Éva A. Enyedy ◽  
Orsolya Dömötör ◽  
Erika Varga ◽  
Tamás Kiss ◽  
Robert Trondl ◽  
...  
Keyword(s):  
Equilibrium Studies ◽  
Solution Equilibrium

Bifunctional 3-hydroxy-4-pyridinones as effective aluminium chelators: synthesis, solution equilibrium studies and in vivo evaluation

2018 ◽  
Vol 186 ◽  
pp. 116-129 ◽  
Author(s):  
Anna Irto ◽  
Paola Cardiano ◽  
Karam Chand ◽  
Rosalia Maria Cigala ◽  
Francesco Crea ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Equilibrium Studies ◽  
Solution Equilibrium ◽  
Synthesis Solution
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