scholarly journals Maternal plasma phosphatidylcholine polyunsaturated fatty acids during pregnancy and offspring growth and adiposity

2017 ◽  
Vol 121 ◽  
pp. 21-29 ◽  
Author(s):  
Jonathan Y. Bernard ◽  
Mya-Thway Tint ◽  
Izzuddin M. Aris ◽  
Ling-Wei Chen ◽  
Phaik Ling Quah ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Maternal Plasma ◽  
Offspring Growth

Fetal and maternal plasma lipids in chronically catheterized mares in late gestation: effects of different nutritional states

1995 ◽  
Vol 7 (5) ◽  
pp. 1275 ◽  
Author(s):  
JP Stammers ◽  
D Hull ◽  
M Silver ◽  
AL Fowden
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Essential Fatty Acids ◽  
Plasma Lipid ◽  
Maternal Plasma ◽  
Late Gestation ◽  
Feeding Patterns ◽  
Normal Feeding ◽  
Group Ii

The effects of different nutritional states on plasma lipid concentrations have been examined in pregnant mares and their fetuses. Maternal and fetal arterial catheters were inserted into 12 pony mares between 244-303 days' gestation (term 320-360 days) and observations made from 5 days following the insertion of catheters. After recovery from surgery maternal and fetal arterial samples were withdrawn from 7 mares with normal feeding patterns (Group IA), from four of these mares at the end of a 30 h fast and 3 h later following refeeding (Group IB) and six mares who failed to re-establish normal feeding patterns (Group II). The fatty acid concentrations and composition of the plasma free fatty acid (FFA), triacylglycerol and phospholipid fractions were analysed. Maternal FFA, triacylglycerol and phospholipid concentrations were significantly raised in the fasted (Group IB) and under-fed (Group II) mares. Fetal concentrations of FFA and phospholipid increased significantly in the group of under-fed (Group II) mares but not in the fasted (Group IB) mares. In the fetal plasma the proportions of polyunsaturated fatty acids derived from essential fatty acids in the FFA and phospholipid fractions were much higher than those in the mare. In the fasted (IB) and under-fed (II) groups the relative amounts of the polyunsaturated fatty acids in each fraction remained unchanged (P > 0.05). These results show a short fast or prolonged undernutrition result in raised maternal plasma lipid concentrations which in turn can effect the total amount of lipid in the fetal circulation. However any increases in polyunsaturated fatty acids in the fetus (e.g. in Group II) are unlikely to come from the maternal circulation; likely sources of these fatty acids are the placenta or fetal tissues.

Polyunsaturated fatty acids in maternal plasma and in breast milk

2002 ◽  
Vol 66 (5-6) ◽  
pp. 535-540 ◽  
Author(s):  
F. Marangoni ◽  
C. Agostoni ◽  
A.M. Lammardo ◽  
M. Bonvissuto ◽  
M. Giovannini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Breast Milk ◽  
Polyunsaturated Fatty Acids ◽  
Maternal Plasma

Maternal plasma n-3 and n-6 polyunsaturated fatty acids during pregnancy and features of fetal health: Fetal growth velocity, birth weight and duration of pregnancy

2018 ◽  
Vol 37 (4) ◽  
pp. 1367-1374 ◽  
Author(s):  
Nina H. Grootendorst-van Mil ◽  
Henning Tiemeier ◽  
Jolien Steenweg-de Graaff ◽  
Berthold Koletzko ◽  
Hans Demmelmair ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Birth Weight ◽  
Polyunsaturated Fatty Acids ◽  
Fetal Growth ◽  
Growth Velocity ◽  
Maternal Plasma ◽  
Fetal Health ◽  
Duration Of Pregnancy

A randomized, double-blind, placebo-controlled study of polyunsaturated fatty acids efficacy in adolescents with anorexia nervosa

2020 ◽  
Vol 36 (2) ◽  
pp. 95-106
Author(s):  
Agnieszka M. Piróg-Balcerzak ◽  
Anna K. Bażyńska ◽  
Katarzyna Biernacka ◽  
Joanna Brągoszewska ◽  
Lidia Popek ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Anorexia Nervosa ◽  
Polyunsaturated Fatty Acids ◽  
Small Sample Size ◽  
Small Sample ◽  
Female Adolescent ◽  
Eating Attitude ◽  
Controlled Study ◽  
Omega 3 ◽  
Eat 26

Objective. Omega–3 polyunsaturated fatty acids (PUFAs) were tested in adolescent depression and in several neurodevelopmental disorders with partial success. Anorexia nervosa (AN) is characterised by deficiencies in fatty food intake and frequent comorbidity, including depressive and cognitive symptoms. Thus supplementation with PUFAs may be beneficial in this group of patients. The aim of the study was to assess whether PUFAs as an add-on treatment is associated with better improvement of body mass index (BMI) and psychopathological symptoms than placebo in patients with AN. Method. 61 female adolescent inpatients with AN were randomly allocated to omega–3 PUFAs supplementation or placebo for 10 weeks. Patients also participated in the behavioural programme and eclectic psychotherapy (treatment as usual, TAU). At baseline and follow-up visits, patients’ BMI and psychopathology were assessed with Clinical Global Impression Scale (CGI), Patient Global Impression Scale (PGI), and Eating Attitude Test (EAT-26). Results. After 10 weeks, both groups showed improvement in all parameters. Improvement in CGI scores was observed greater in placebo vs. PUFA-s group (p = 0.015) while other differences were not statistically significant. Omega–3 PUFAs supplementation appears not to be effective as an add-on treatment in inpatient adolescent girls with anorexia nervosa. Conclusions. The results should be analysed with caution due to small sample size and heterogeneity in TAU. As the TAU turned out to be highly effective, additional therapeutic effect of PUFA might not be visible. Nevertheless, that does not explain the tendency for better improvement in the placebo group.

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