A rat model of maternal intermittent fasting during pregnancy impairs fetal growth but does not alter maternofetal folate transport

Placenta ◽  
2017 ◽  
Vol 57 ◽  
pp. 286 ◽  
Author(s):  
Rezwana Hussain ◽  
May Tassabehji ◽  
Nick Ashton ◽  
Jocelyn Glazier
Keyword(s):  
Fetal Growth ◽  
Rat Model ◽  
Intermittent Fasting ◽  
Folate Transport

The effect of copper deficiency on fetal growth and liver anti-oxidant capacity in the Cohen diabetic rat model

2012 ◽  
Vol 265 (2) ◽  
pp. 209-220 ◽  
Author(s):  
Zivanit Ergaz ◽  
Dana Shoshani-Dror ◽  
Claire Guillemin ◽  
Meytal Neeman-azulay ◽  
Liza Fudim ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Rat Model ◽  
Copper Deficiency ◽  
Diabetic Rat ◽  
Anti Oxidant ◽  
Effect Of Copper ◽  
Diabetic Rat Model

scholarly journals Fetal programming effects of pentaerythritol tetranitrate in a rat model of superimposed preeclampsia

2020 ◽  
Vol 98 (9) ◽  
pp. 1287-1299
Author(s):  
Andy W. C. Man ◽  
Min Chen ◽  
Yawen Zhou ◽  
Zhixiong Wu ◽  
Gisela Reifenberg ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Tolerance ◽  
Fetal Growth ◽  
Rat Model ◽  
High Salt ◽  
Pentaerythritol Tetranitrate ◽  
High Salt Diet ◽  
Blood Pressure Elevation ◽  
Salt Diet ◽  
Normal Chow

Abstract Preeclampsia is a common medical condition during pregnancy and a major cause of maternal and prenatal mortality. The present study was conducted to investigate the effects of maternal treatment with pentaerythritol tetranitrate (PETN) in Dahl salt-sensitive rats (DSSR), a model of superimposed preeclampsia. F0 parental DSSR were treated with PETN (50 mg/kg) from the time point of mating to the end of lactation. Maternal PETN treatment improved fetal growth and had no effect on blood pressure in DSSR offspring fed with normal chow or high-salt diet. Upon high-fat diet (HFD) feeding, offspring from PETN-treated mother showed improved glucose tolerance despite similar weight gain. Unexpectedly, maternal PETN treatment significantly potentiated the HFD-induced blood pressure elevation in male DSSR offspring. Endothelium-derived hyperpolarization factor (EDHF)-mediated vasodilation was similar between NCD-fed and HFD-fed control offspring but was markedly reduced in HFD-fed PETN offspring. EDHF genes were downregulated in the vasculature of HFD-fed PETN offspring, which was associated with epigenetic changes in histone modifications. In conclusion, maternal PETN treatment in DSSR shows both beneficial and unfavorable effects. It improves fetal growth and ameliorates glucose tolerance in the offspring. Although maternal PETN treatment has no effect on blood pressure in offspring fed with normal chow or high-salt diet, the offspring is at higher risk to develop HFD-induced hypertension. PETN may potentiate the blood pressure response to HFD by epigenetic modifications of EDHF genes. Key messages The core findings of this article suggest that maternal PETN treatment of DSSR, a rat model of a spontaneous superimposed preeclampsia, leads to • Improvement of fetal growth; • No changes of maternal blood pressure or markers of preeclampsia; • Amelioration of HFD-induced glucose intolerance in adult offspring; • No changes in blood pressure development of the offspring on normal chow or high salt-diet; • Potentiation of blood pressure elevation of the offspring on HFD.

657: Serelaxin reduces mean arterial pressure (MAP) and improves fetal growth in the RUPP rat model of preeclampsia

2015 ◽  
Vol 212 (1) ◽  
pp. S324
Author(s):  
Jose Santiago-Font ◽  
Lorena Amaral ◽  
Ellen Gillis ◽  
Janae Moseley ◽  
Babbette LaMarca ◽  
...  
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Fetal Growth ◽  
Rat Model

Inflammation-induced fetal growth restriction and pre-eclampsia are linked to alterations in placental morphometrics in a rat model

Placenta ◽  
2013 ◽  
Vol 34 (9) ◽  
pp. A22-A23
Author(s):  
Tiziana Cotechini ◽  
Shannyn K. Macdonald-Goodfellow ◽  
Charles H. Graham
Keyword(s):  
Fetal Growth ◽  
Rat Model ◽  
Fetal Growth Restriction ◽  
Growth Restriction

Maternal intermittent fasting during pregnancy: a translational research challenge for an important clinical scenario

2021 ◽  
Vol 135 (17) ◽  
pp. 2099-2102
Author(s):  
Dominique Darmaun
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Fetal Growth ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Intermittent Fasting ◽  
Pregnant Rats ◽  
Ramadan Fasting ◽  
Clear Cut ◽  
Research Challenge

Abstract In volume 135, issue 11 of Clinical Science, Alkhalefah et al. report that, in pregnant rats, repeated, cyclic fasting, mimicking the fasting experienced by observant Muslim pregnant women during Ramadan, alters placental amino acid transport and increases the incidence of low birth weight. Though Muslim women are exempt, many observe Ramadan: >500 million fetuses worldwide may be exposed to Ramadan fasting in each generation, and low birth weight increases the risk of developing chronic disease in the future adult. Several mechanisms, including altered circadian rhythm, maternal stress, undernutrition or compensatory overeating at the breaking of fast, could, in theory, impact fetal growth during Ramadan. Limitations of the experimental model obviously prevent direct extrapolation to humans. Whether Ramadan fasting indeed affect fetal growth therefore remains unclear, as there is no clear-cut evidence from epidemiological studies. The paper illustrates the need to design further case-controlled studies in large cohorts of women who fasted at various stages of pregnancy, compared to appropriately matched women who did not fast, as well as more experimental studies focused on this issue of public health relevance.

Metolazone ameliorates the hypertension and fetal growth restriction in a rat model of preeclampsia

2003 ◽  
Vol 189 (6) ◽  
pp. S90
Author(s):  
Gabriella Pridjian ◽  
Monica Ianosi-Irimie ◽  
Hop Vu ◽  
Candice Pridjian ◽  
Janelle Durst ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Rat Model ◽  
Fetal Growth Restriction ◽  
Growth Restriction

scholarly journals Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mark W. Cunningham ◽  
Lorena M. Amaral ◽  
Nathan E. Campbell ◽  
Denise C. Cornelius ◽  
Tarek Ibrahim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nk Cells ◽  
Fetal Growth ◽  
Rat Model ◽  
Fetal Growth Restriction ◽  
Nk Cell ◽  
Interleukin 2 ◽  
Growth Restriction ◽  
High Dose ◽  
Fetal Survival

AbstractTwo important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) preclinical rat model of PE exhibits both of these features. Moreover, RUPP and PE women have elevated vasoconstrictor peptide endothelin-1 (ET-1) and inflammation. Interleukin-2 (IL-2) is a cytokine that regulates NK cell activity and is elevated in miscarriage, PE, and RUPP rats. The objective of this study was to examine a role for IL-2 in NK cell activation, fetal growth restriction, and hypertension during pregnancy by either infusion of IL-2 or blockade of IL-2 (basiliximab) in normal pregnant (NP) and RUPP rats. On gestational day 14, NP and RUPP rats received low (LD), middle (MD), or high dose (HD) IL-2 (0.05, 0.10, or 0.20 ng/ml) IP or basiliximab (0.07 mg per rat) by IV infusion. On day 19, blood pressure (MAP), pup weights, and blood were collected. Basiliximab had no effect on blood pressure, however, significantly lowered NK cells and may have worsened overall fetal survival in RUPP rats. However, IL-2 LD (102 ± 4 mmHg) and IL-2 HD (105 ± 6 mmHg) significantly lowered blood pressure, ET-1, and activated NK cells compared to control RUPPs (124 ± 3 mmHg, p < 0.05). Importantly, IL-2 in RUPP rats significantly reduced fetal weight and survival. These data indicate that although maternal benefits may have occurred with low dose IL-2 infusion, negative effects were seen in the fetus. Moreover, inhibition of IL-2 signaling did not have favorable outcome for the mother or fetus.

scholarly journals Spinal fusion with demineralized calf fetal growth plate as novel biomaterial in rat model: a preliminary study

10.14444/1005 ◽  
2014 ◽  
Vol 8 ◽  
pp. 5 ◽  
Author(s):  
Amin Bigham-Sadegh ◽  
Iraj Karimi ◽  
Ahmad Oryan ◽  
Elena Mahmoudi ◽  
Zahra Shafiei-Sarvestani
Keyword(s):  
Spinal Fusion ◽  
Growth Plate ◽  
Fetal Growth ◽  
Rat Model ◽  
Preliminary Study
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