Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots

2020 ◽  
Vol 174 ◽  
pp. 112337 ◽  
Author(s):  
Dongdong Zhang ◽  
Deqing Ruan ◽  
Jingyi Li ◽  
Zhaoqiang Chen ◽  
Weiliang Zhu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Indole Alkaloids ◽  
Isatis Tinctoria ◽  
Inhibitory Activities ◽  
Sulfur Containing

scholarly journals New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26

2021 ◽  
Vol 12 ◽  
Author(s):  
Guojun Pan ◽  
Yanling Li ◽  
Xinyu Che ◽  
Dan Tian ◽  
Wenjie Han ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Natural Products ◽  
Spectroscopic Data ◽  
Rhizosphere Soil ◽  
New Family ◽  
Inhibitory Activities ◽  
Anti Inflammatory ◽  
Aspergillus Sp ◽  
Sulfur Containing

Two new thio-compounds named aspergerthinol A and B (1 and 2) and two new monoterpenes named aspergerthinacids A and B (3 and 4) were isolated from the fungus Aspergillus sp. CYH26 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds 1 and 2 represented a new family of sulfur containing natural products with a 3-methyl-4H-cyclopenta[b]thiophen-4-one skeleton. Compounds 1–4 showed inhibitory activities against nitric oxide (NO) with IC50 values of 38.0, 19.8, 46.3, and 56.6 μM, respectively.

scholarly journals Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1026 ◽  
Author(s):  
Almir de Carvalho Junior ◽  
Rafaela Oliveira Ferreira ◽  
Michel de Souza Passos ◽  
Samyra da Silva Boeno ◽  
Lorena Glória das Virgens ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Indole Alkaloids ◽  
Antimycobacterial Activity ◽  
No Production ◽  
Nitric Oxide Production ◽  
In Vitro Activity ◽  
Phytochemical Study ◽  
Pomolic Acid ◽  
Inhibitory Activities

A phytochemical study of leaves and twigs of Psychotria nuda resulted in 19 compounds, including five indole alkaloids, N,N,N-trimethyltryptamine, lyaloside, strictosamide, strictosidine, and 5α-carboxystrictosidine; two flavonolignans, cinchonain Ia and cinchonain Ib; an iridoid, roseoside; a sugar, lawsofructose; a coumarin, scopoletin; a diterpene, phytol; three triterpenes, pomolic acid, spinosic acid, and rotungenic acid; and five steroids, sitosterol, stigmasterol, campesterol, β-sitosterol-3-O-β-d-glucoside, and β-stigmasterol-3-O-β-d-glucoside. Some compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis and their ability to inhibit NO production by macrophages stimulated by lipopolysaccharide (LPS). The compounds pomolic acid, spinosic acid, strictosidine, and 5α-carboxystrictosidine displayed antimycobacterial activity with minimum inhibitory concentrations ranging from 7.1 to 19.2 µg/mL. These compounds showed promising inhibitory activity against NO production (IC50 3.22 to 25.5 μg/mL). 5α-carboxystrictosidine did not show cytotoxicity against macrophages RAW264.7 up to a concentration of 100 µg/mL. With the exception of strictosamide, this is the first report of the occurrence of these substances in P. nuda.

Structurally diverse steroids with nitric oxide inhibitory activities from Aglaia lawii leaves

2021 ◽  
Vol 183 ◽  
pp. 112651
Author(s):  
Jin-Feng Li ◽  
Kai-Long Ji ◽  
Peng Sun ◽  
Qiang Cai ◽  
Xiao-Ling Zheng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inhibitory Activities

scholarly journals Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production

2011 ◽  
Vol 59 (5) ◽  
pp. 653-656 ◽  
Author(s):  
Shuang Liang ◽  
Jun-Mian Tian ◽  
Yi Feng ◽  
Xiao-Hua Liu ◽  
Zhi Xiong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Inhibitory Activities

scholarly journals Sesquiterpenes from Curcuma wenyujin with their inhibitory activities on nitric oxide production in RAW 264.7 cells

2016 ◽  
Vol 31 (5) ◽  
pp. 548-554 ◽  
Author(s):  
Suyu Gao ◽  
Guiyang Xia ◽  
Liqing Wang ◽  
Li Zhou ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Inhibitory Activities

Eudesmane-Type Sesquiterpenes fromCurcuma phaeocaulisand Their Inhibitory Activities on Nitric Oxide Production in RAW 264.7 Cells

2014 ◽  
Vol 2014 (25) ◽  
pp. 5540-5548 ◽  
Author(s):  
Yue Liu ◽  
Jianghao Ma ◽  
Ying Wang ◽  
Paul Owusu Donkor ◽  
Qin Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Inhibitory Activities

Cytotoxic and nitric oxide inhibitory activities of methanol extracts ofGarciniaspecies

2009 ◽  
Vol 47 (11) ◽  
pp. 1019-1026 ◽  
Author(s):  
Md. Lip Jabit ◽  
Fatma Sri Wahyuni ◽  
Rozida Khalid ◽  
Daud Ahmad Israf ◽  
Khozirah Shaari ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Methanol Extracts ◽  
Inhibitory Activities

ChemInform Abstract: Inhibitory Activities of Kojyl Thioether Derivatives Against Nitric Oxide Production Induced by Lipopolysaccharide.

ChemInform ◽  
2011 ◽  
Vol 42 (12) ◽  
pp. no-no
Author(s):  
Ho Sik Rho ◽  
Dae Sung Yoo ◽  
Soo Mi Ahn ◽  
Myung Kyoo Kim ◽  
Dong Ha Cho ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Inhibitory Activities
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