γ -Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178

2017 ◽  
Vol 137 ◽  
pp. 165-173 ◽  
Author(s):  
Patima Phainuphong ◽  
Vatcharin Rukachaisirikul ◽  
Kwanruthai Tadpetch ◽  
Yaowapa Sukpondma ◽  
Saowanit Saithong ◽  
...  
Keyword(s):  
Aspergillus Sclerotiorum

scholarly journals Ensaio laboratorial e clínico com Hycanthone, nôvo agente esquistossomicida

1967 ◽  
Vol 1 (4) ◽  
pp. 219-230 ◽  
Author(s):  
Naftale Katz ◽  
J. Pellegrino
Keyword(s):  
Schistosoma Mansoni ◽  
Aspergillus Sclerotiorum

A partir do Miracil D, um derivado hidroximetílico (Hycanthone) pode ser obtido através da atividade biológica do Aspergillus sclerotiorum. Êste derivado mostrou-se muito ativo quando administrado a camundongos, hamsters e macacos Cebus experimentalmente infectados com Schistosoma mansoni. Ensaios clínicos com o Hycanthone foram feitos em 52 pacientes com esquistossomose mansoni ativa. A droga foi administrada, nas doses de 2 e 3 mg/kg/ dia, junto com um anti-ácido, duas vêzes ao dia, durante 5 dias consecutivos. Com exceção de 2 casos, todos os pacientes completaram o tratamento. Náusea e/ou vômito, anorexia, tonturas e cefaléia foram os efeitos colaterais mais comuns. Atividade terapêutica foi avaliada através de repetidos exames de fezes (4 a 6) e uma biópsia retal realizada a partir do 4.° mês após o tratamento. As percentagens de cura foram de 83,3 e 80,0% com o esquema de 2 e 3 mg/kg, respectivamente. Os dados laboratoriais e clínicos sôbre a atividade esquistossomicida do Hycanthone até agora obtidos mostram a necessidade de novos ensaios com êste promissor medicamento.

Microbial Transformation of Phenazines by Aspergillus Sclerotiorum

Mycologia ◽  
1969 ◽  
Vol 61 (3) ◽  
pp. 452-467 ◽  
Author(s):  
James C. Hill ◽  
George T. Johnson
Keyword(s):  
Microbial Transformation ◽  
Aspergillus Sclerotiorum

Novel Cyclic Hexapeptides from Marine-Derived Fungus, Aspergillus sclerotiorum PT06-1

2009 ◽  
Vol 11 (22) ◽  
pp. 5262-5265 ◽  
Author(s):  
Jinkai Zheng ◽  
Huajie Zhu ◽  
Kui Hong ◽  
Yi Wang ◽  
Peipei Liu ◽  
...  
Keyword(s):  
Cyclic Hexapeptides ◽  
Aspergillus Sclerotiorum

ChemInform Abstract: A New Cytotoxic Indole-3-ethenamide from the Halotolerant Fungus Aspergillus sclerotiorum PT06-1.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Hui Wang ◽  
Jin-Kai Zheng ◽  
Hai-Jun Qu ◽  
Pei-Pei Liu ◽  
Yi Wang ◽  
...  
Keyword(s):  
Halotolerant Fungus ◽  
Aspergillus Sclerotiorum

scholarly journals Antispasmodic Effect of Asperidine B, a Pyrrolidine Derivative, through Inhibition of L-Type Ca2+ Channel in Rat Ileal Smooth Muscle

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5492
Author(s):  
Acharaporn Duangjai ◽  
Vatcharin Rukachaisirikul ◽  
Yaowapa Sukpondma ◽  
Chutima Srimaroeng ◽  
Chatchai Muanprasat
Keyword(s):  
Methylene Blue ◽  
Inhibitory Effect ◽  
Organ Bath ◽  
Terrestrial Plants ◽  
Tetraethylammonium Chloride ◽  
Rat Ileum ◽  
K Channels ◽  
Antispasmodic Effect ◽  
Set Up ◽  
Aspergillus Sclerotiorum

Antispasmodic agents are used for modulating gastrointestinal motility. Several compounds isolated from terrestrial plants have antispasmodic properties. This study aimed to explore the inhibitory effect of the pyrrolidine derivative, asperidine B, isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178, on spasmodic activity. Isolated rat ileum was set up in an organ bath. The contractile responses of asperidine B (0.3 to 30 µM) on potassium chloride and acetylcholine-induced contractions were recorded. To investigate its antispasmodic mechanism, CaCl2, acetylcholine, Nω-nitro-l-arginine methyl ester (l-NAME), nifedipine, methylene blue and tetraethylammonium chloride (TEA) were tested in the absence or in the presence of asperidine B. Cumulative concentrations of asperidine B reduced the ileal contraction by ~37%. The calcium chloride and acetylcholine-induced ileal contraction was suppressed by asperidine B. The effects of asperidine B combined with nifedipine, atropine or TEA were similar to those treated with nifedipine, atropine or TEA, respectively. In contrast, in the presence of l-NAME and methylene blue, the antispasmodic effect of asperidine B was unaltered. These results suggest that the antispasmodic property of asperidine B is probably due to the blockage of the L-type Ca2+ channel and is associated with K+ channels and muscarinic receptor, possibly by affecting non-selective cation channels and/or releasing intracellular calcium.

scholarly journals Optimization of the Production of Lovastatin from Aspergillus sclerotiorum PSU- RSPG178 under Static Liquid Culture using Response Surface Methodology

2019 ◽  
Vol 48 (1) ◽  
pp. 93-102
Author(s):  
Sudarat Suwannarat ◽  
Jutarut Iewkittayakorn ◽  
Yaowapa Sukpondma ◽  
Vatcharin Rukachaisirikul ◽  
Souwalak Phongpaichit ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Liquid Culture ◽  
Aspergillus Sclerotiorum

scholarly journals Evaluation of Metal Tolerance of Fungal Strains Isolated from Contaminated Mining Soil of Nanjing, China

Biology ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 469
Author(s):  
Fiza Liaquat ◽  
Muhammad Farooq Hussain Munis ◽  
Urooj Haroon ◽  
Samiah Arif ◽  
Saddam Saqib ◽  
...  
Keyword(s):  
Contaminated Soils ◽  
Metal Tolerance ◽  
Morphological Changes ◽  
Tolerance Index ◽  
Metal Analysis ◽  
Aspergillus Aculeatus ◽  
Yeast Strains ◽  
High Concentrations ◽  
Induced Tolerance ◽  
Aspergillus Sclerotiorum

Rapidly increasing industry has resulted in greater discharge of hazardous chemicals in the soil. In the current study, soil samples were collected from Nanjing mine (32°09′19.29″ N 118°56′57.04″ E) and subjected to heavy metal analysis and microbe isolation. A total of 460 fungi were isolated, and five of these were yeast strains. Most of the strains exhibited tolerance to one metal. Five multimetal tolerant strains were selected and identified as Aspergillus sclerotiorum, Aspergillus aculeatus, Komagataella phaffii, Trichoderma harzianum, and Aspergillus niger. Isolated strains were grown in high concentrations of cadmium (Cd), chromium (Cr) and lead (Pb), for induced-tolerance training. The tolerance index (TI) revealed the highest Cd tolerance of novel K. phaffii strain at 5500 ppm (TI: 0.2). K. phaffii also displayed resistance at 4000 ppm against Cr (TI: 0.32) and Pb (TI: 0.32). In contrast, tolerance training for A. niger was not that successful. K. phaffii also displayed the highest bioaccumulation capacity for Cd (25.23 mg/g), Cu (21.63 mg/g), and Pb (20.63 mg/g) at 200 ppm. Scanning electron microscopy (SEM) explored the morphological changes in the mycelia of stressed fungi. Results of this study describe this delicate approach to be species and metal dependent and suggest a potential utilization of this fungal strain for the bioremediation of contaminated soils.

scholarly journals A new cytotoxic indole-3-ethenamide from the halotolerant fungus Aspergillus sclerotiorum PT06-1

2011 ◽  
Vol 64 (10) ◽  
pp. 679-681 ◽  
Author(s):  
Hui Wang ◽  
Jin-Kai Zheng ◽  
Hai-Jun Qu ◽  
Pei-Pei Liu ◽  
Yi Wang ◽  
...  
Keyword(s):  
Halotolerant Fungus ◽  
Aspergillus Sclerotiorum

Asperidines A–C, pyrrolidine and piperidine derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178

2018 ◽  
Vol 26 (15) ◽  
pp. 4502-4508 ◽  
Author(s):  
Patima Phainuphong ◽  
Vatcharin Rukachaisirikul ◽  
Saowanit Saithong ◽  
Souwalak Phongpaichit ◽  
Jariya Sakayaroj ◽  
...  
Keyword(s):  
Aspergillus Sclerotiorum

Aspergillus sclerotiorum  : à propos d’un cas d’onychomycose en Tunisie

2010 ◽  
Vol 20 (2) ◽  
pp. 128-132 ◽  
Author(s):  
M. Amri ◽  
M. Gorcii ◽  
N. Essabbah ◽  
H. Belhajali ◽  
V. Letscher-Bru ◽  
...  
Keyword(s):  
Aspergillus Sclerotiorum
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