Novel Cyclic Hexapeptides from Marine-Derived Fungus, Aspergillus sclerotiorum PT06-1

2009 ◽  
Vol 11 (22) ◽  
pp. 5262-5265 ◽  
Author(s):  
Jinkai Zheng ◽  
Huajie Zhu ◽  
Kui Hong ◽  
Yi Wang ◽  
Peipei Liu ◽  
...  
Keyword(s):  
Cyclic Hexapeptides ◽  
Aspergillus Sclerotiorum

scholarly journals Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031

Marine Drugs ◽  
2021 ◽  
Vol 19 (12) ◽  
pp. 701
Author(s):  
Jieyi Long ◽  
Yaqi Chen ◽  
Weihao Chen ◽  
Junfeng Wang ◽  
Xuefeng Zhou ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Soft Coral ◽  
2D Nmr ◽  
X Ray Diffraction ◽  
X Ray ◽  
Cyclic Hexapeptide ◽  
Ic50 Value ◽  
Ic50 Values ◽  
Cyclic Hexapeptides ◽  
Aspergillus Sclerotiorum

Three novel cyclic hexapeptides, sclerotides C–E (1–3), and a new lipodepsipeptide, scopularide I (4), together with a known cyclic hexapeptide sclerotide A (5), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey’s method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I (4) exhibited acetylcholinesterase inhibitory activity with an IC50 value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC50 values of 10.1 μM.

scholarly journals Anabaenopeptins: What We Know So Far

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 522
Author(s):  
Patrick Romano Monteiro ◽  
Samuel Cavalcante do Amaral ◽  
Andrei Santos Siqueira ◽  
Luciana Pereira Xavier ◽  
Agenor Valadares Santos
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Inhibitory Activity ◽  
Important Class ◽  
Biotechnological Applications ◽  
Peptide Synthetases ◽  
Ecological Roles ◽  
Cyclic Hexapeptides ◽  
Key Features

Cyanobacteria are microorganisms with photosynthetic mechanisms capable of colonizing several distinct environments worldwide. They can produce a vast spectrum of bioactive compounds with different properties, resulting in an improved adaptative capacity. Their richness in secondary metabolites is related to their unique and diverse metabolic apparatus, such as Non-Ribosomal Peptide Synthetases (NRPSs). One important class of peptides produced by the non-ribosomal pathway is anabaenopeptins. These cyclic hexapeptides demonstrated inhibitory activity towards phosphatases and proteases, which could be related to their toxicity and adaptiveness against zooplankters and crustaceans. Thus, this review aims to identify key features related to anabaenopeptins, including the diversity of their structure, occurrence, the biosynthetic steps for their production, ecological roles, and biotechnological applications.

scholarly journals Solid-phase synthesis of cyclic hexapeptides wollamides A, B and desotamide B

2017 ◽  
Vol 58 (27) ◽  
pp. 2675-2680 ◽  
Author(s):  
Lissa S. Tsutsumi ◽  
Ghee T. Tan ◽  
Dianqing Sun
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Cyclic Hexapeptides

ChemInform Abstract: The First Total Synthesis of Deoxybouvardin and RA-VII, Novel Antitumor Cyclic Hexapeptides.

ChemInform ◽  
1988 ◽  
Vol 19 (1) ◽  
Author(s):  
T. INABA ◽  
I. UMEZAWA ◽  
M. YUASA ◽  
T. INOUE ◽  
S. MIHASHI ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cyclic Hexapeptides

Circular dichroism of cyclic hexapeptides with one and two side chains

Biochemistry ◽  
1971 ◽  
Vol 10 (8) ◽  
pp. 1330-1335 ◽  
Author(s):  
C. Allen Bush ◽  
Stanley M. Ziegler
Keyword(s):  
Circular Dichroism ◽  
Side Chains ◽  
Cyclic Hexapeptides ◽  
Circular Dichroïsm

Ferintoic Acids A and B, New Cyclic Hexapeptides from the Freshwater CyanobacteriumMicrocystisaeruginosa

1996 ◽  
Vol 59 (6) ◽  
pp. 570-575 ◽  
Author(s):  
David E. Williams ◽  
Marcia Craig ◽  
Charles F. B. Holmes ◽  
Raymond J. Andersen
Keyword(s):  
Cyclic Hexapeptides

scholarly journals Ensaio laboratorial e clínico com Hycanthone, nôvo agente esquistossomicida

1967 ◽  
Vol 1 (4) ◽  
pp. 219-230 ◽  
Author(s):  
Naftale Katz ◽  
J. Pellegrino
Keyword(s):  
Schistosoma Mansoni ◽  
Aspergillus Sclerotiorum

A partir do Miracil D, um derivado hidroximetílico (Hycanthone) pode ser obtido através da atividade biológica do Aspergillus sclerotiorum. Êste derivado mostrou-se muito ativo quando administrado a camundongos, hamsters e macacos Cebus experimentalmente infectados com Schistosoma mansoni. Ensaios clínicos com o Hycanthone foram feitos em 52 pacientes com esquistossomose mansoni ativa. A droga foi administrada, nas doses de 2 e 3 mg/kg/ dia, junto com um anti-ácido, duas vêzes ao dia, durante 5 dias consecutivos. Com exceção de 2 casos, todos os pacientes completaram o tratamento. Náusea e/ou vômito, anorexia, tonturas e cefaléia foram os efeitos colaterais mais comuns. Atividade terapêutica foi avaliada através de repetidos exames de fezes (4 a 6) e uma biópsia retal realizada a partir do 4.° mês após o tratamento. As percentagens de cura foram de 83,3 e 80,0% com o esquema de 2 e 3 mg/kg, respectivamente. Os dados laboratoriais e clínicos sôbre a atividade esquistossomicida do Hycanthone até agora obtidos mostram a necessidade de novos ensaios com êste promissor medicamento.

ChemInform Abstract: CONFORMATION OF CYCLIC PEPTIDES PART 7, CYCLIC HEXAPEPTIDES CONTAINING THE D-PHE-L-PRO SEQUENCE

1973 ◽  
Vol 4 (45) ◽  
pp. no-no
Author(s):  
KENNETH D. KOPPLE ◽  
ANITA GO ◽  
THOMAS J. SCHAMPER ◽  
CRAIG S. WILCOX
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Hexapeptides
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