Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines

2013 ◽  
Vol 86 ◽  
pp. 208-217 ◽  
Author(s):  
Milka Jadranin ◽  
Milica Pešić ◽  
Ivana S. Aljančić ◽  
Slobodan M. Milosavljević ◽  
Nina M. Todorović ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
P Glycoprotein

scholarly journals Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2161 ◽  
Author(s):  
Yu Zhao ◽  
Tian-En Wang ◽  
Alberto Mills ◽  
Federico Gago ◽  
Wei-Shuo Fang
Keyword(s):  
Molecular Modeling ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
Conformationally Constrained ◽  
Loop Region ◽  
P Glycoprotein

A series of novel 7,9-O-linked macrocyclic taxoids together with modification at the C2 position were synthesized, and their cytotoxicities against drug-sensitive and P-glycoprotein and βIII-tubulin overexpressed drug-resistant cancer cell lines were evaluated. It is demonstrated that C-seco taxoids conformationally constrained via carbonate containing-linked macrocyclization display increased cytotoxicity on drug-resistant tumors overexpressing both βIII and P-gp, among which compound 22b, bearing a 2-m-methoxybenzoyl group together with a five-atom linker, was identified as the most potent. Molecular modeling suggested the improved cytotoxicity of 22b results from enhanced favorable interactions with the T7 loop region of βIII.

1008 Characterization of Newly Established P-glycoprotein Over-expressing Multi-drug Resistant Human Cancer Cell Lines

2012 ◽  
Vol 48 ◽  
pp. S243-S244
Author(s):  
A. Podolski-Renic ◽  
M. Pesic ◽  
M. Chiourea ◽  
J. Bankovic ◽  
T. Andjelkovic ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
P Glycoprotein

scholarly journals CD40 is Positively Correlated with the Expression of Nucleophosmin in Cisplatin-Resistant Bladder Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Chenshuo Luo ◽  
Ting Lei ◽  
Man Zhao ◽  
Qian Meng ◽  
Man Zhang
Keyword(s):  
Bladder Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gene Knockout ◽  
Cancer Cell Lines ◽  
Fold Change ◽  
Bladder Cancer Cell ◽  
Drug Resistant ◽  
Go Analysis ◽  
Differential Proteins

Objective. To verify and evaluate the value of CD40 as a noninvasive biomarker of cisplatin-resistant bladder cancer, we studied the expression of CD40 and the correlation between nucleophosmin (NPM1) and CD40 in cisplatin-resistant bladder cancer. Methods. Three cisplatin-resistant bladder cancer cell lines (T24/0.8DDP, BIU87/0.3DDP, and PUMC-91/0.6DDP) were studied, and lentivirus was used to silence NPM1 expression. The expression of CD40 and NPM1 in three NPM1 silencing bladder cancer cell lines were detected by fluorescence microscopy and Western Blot. The effects and proteomic bioinformatics of NPM1 gene knockout on cisplatin-resistant bladder cancer cells were analyzed by liquid chromatography-mass spectrometry (LC-MS) and gene ontology analysis (GO analysis). Results. The NPM1 gene was successfully silenced in three drug-resistant bladder cancer cell lines by lentivirus infection. The knockdown efficiency was 70%. After NPM1 gene knockout, 492 differential proteins were detected by LC-MS, whose fold change was more than 1.5 p<0.05. A total of 57022 peptides, 54347 unique peptides, and 6686 protein groups were identified in all proteins of the tested cells (FDR < 0.01). Hierarchical clustering and principal component analysis showed that 264 functional proteins were downregulated and 228 functional proteins were upregulated in the gene silencing group compared with those of the negative controls. By GO analysis, the proteins affected by NPM1 cover a large number of proteins with biological functions, which may play an important role in the development of tumor in 492 differential proteins. The CD40 was the most significantly downregulated protein after NPM1 silencing, with a difference of 2.6-fold change in abundance. Conclusions. There is a positive correlation between CD40 protein and NPM1 protein in drug-resistant bladder cancer. Because NPM1 can reflect the characteristics of bladder cancer, CD40 may be a more sensitive marker for monitoring the prognosis of bladder cancer.

Enhanced Efficacy of Gefitinib in Drug‐Sensitive and Drug‐Resistant Cancer Cell Lines after Arming with a Singlet Oxygen Releasing Moiety

ChemMedChem ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. 794-798
Author(s):  
Kunshan Huang ◽  
Beibei Huo ◽  
Dongyao Li ◽  
Jinping Xue ◽  
Juanjuan Chen
Keyword(s):  
Singlet Oxygen ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant

scholarly journals Drug-Resistant Urothelial Cancer Cell Lines Display Diverse Sensitivity Profiles to Potential Second-Line Therapeutics

2015 ◽  
Vol 8 (3) ◽  
pp. 210-216 ◽  
Author(s):  
Stefan Vallo ◽  
Martin Michaelis ◽  
Florian Rothweiler ◽  
Georg Bartsch ◽  
Kilian M. Gust ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Urothelial Cancer ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
Second Line ◽  
Urothelial Cancer Cell

Comprehensive Study of Sansalvamide A Derivatives and their Structure–Activity Relationships against Drug-Resistant Colon Cancer Cell Lines

2008 ◽  
Vol 51 (3) ◽  
pp. 530-544 ◽  
Author(s):  
Katerina Otrubova ◽  
Gerald Lushington ◽  
David Vander Velde ◽  
Kathleen L. McGuire ◽  
Shelli R. McAlpine
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Drug Resistant ◽  
Structure Activity ◽  
Colon Cancer Cell Lines ◽  
Sansalvamide A ◽  
Comprehensive Study

scholarly journals Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Radosław Januchowski ◽  
Karolina Sterzyńska ◽  
Katarzyna Zaorska ◽  
Patrycja Sosińska ◽  
Andrzej Klejewski ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Cross Resistance ◽  
Drug Resistant ◽  
Ovarian Cancer Cell Lines ◽  
Genes Expression ◽  
Mdr Genes

scholarly journals Expression of microRNA-30a-5p in drug-resistant and drug-sensitive ovarian cancer cell lines

2016 ◽  
Vol 12 (3) ◽  
pp. 2065-2070 ◽  
Author(s):  
Jin Liu ◽  
Xiaohua Wu ◽  
Hongmei Liu ◽  
Yijuan Liang ◽  
Xinping Gao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
Ovarian Cancer Cell Lines

Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines

2013 ◽  
Vol 67 (3) ◽  
pp. 240-245 ◽  
Author(s):  
Radosław Januchowski ◽  
Piotr Zawierucha ◽  
Małgorzata Andrzejewska ◽  
Marcin Ruciński ◽  
Maciej Zabel
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Expression Analysis ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
Slc Transporters ◽  
Ovarian Cancer Cell Lines
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