Heterogeneity of DNA-damage in ovarian cancer cell lines A2780-WT and multiple drug resistant (mdr) A2780-Dox-5 treated with adriamycin(ADM)

1995 ◽  
Vol 121 (S1) ◽  
pp. A54-A54
Author(s):  
C. Schöber ◽  
J. Gibbs ◽  
M. B. Yin ◽  
C. Frank ◽  
C. Wroszek ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Dna Damage ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Ovarian Cancer Cell Lines ◽  
Multiple Drug Resistant

scholarly journals Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Radosław Januchowski ◽  
Karolina Sterzyńska ◽  
Katarzyna Zaorska ◽  
Patrycja Sosińska ◽  
Andrzej Klejewski ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Cross Resistance ◽  
Drug Resistant ◽  
Ovarian Cancer Cell Lines ◽  
Genes Expression ◽  
Mdr Genes

scholarly journals Expression of microRNA-30a-5p in drug-resistant and drug-sensitive ovarian cancer cell lines

2016 ◽  
Vol 12 (3) ◽  
pp. 2065-2070 ◽  
Author(s):  
Jin Liu ◽  
Xiaohua Wu ◽  
Hongmei Liu ◽  
Yijuan Liang ◽  
Xinping Gao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
Ovarian Cancer Cell Lines

Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines

2013 ◽  
Vol 67 (3) ◽  
pp. 240-245 ◽  
Author(s):  
Radosław Januchowski ◽  
Piotr Zawierucha ◽  
Małgorzata Andrzejewska ◽  
Marcin Ruciński ◽  
Maciej Zabel
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Expression Analysis ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
Slc Transporters ◽  
Ovarian Cancer Cell Lines

scholarly journals A Novel Salt Inducible Kinase 2 Inhibitor, ARN-3261, Sensitizes Ovarian Cancer Cell Lines and Xenografts to Carboplatin

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 446
Author(s):  
Dengxuan Fan ◽  
Hailing Yang ◽  
Weiqun Mao ◽  
Philip J. Rask ◽  
Lan Pang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Dna Damage ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Ovarian Cancer Cells ◽  
Enhanced Sensitivity ◽  
Ovarian Cancer Cell Lines ◽  
Xenograft Models

Salt-induced kinase 2 (SIK2) is a serine-threonine kinase that regulates centrosome splitting, activation of PI3 kinase and phosphorylation of class IIa HDACs, affecting gene expression. Previously, we found that inhibition of SIK2 enhanced sensitivity of ovarian cancer cells to paclitaxel. Carboplatin and paclitaxel constitute first-line therapy for most patients with ovarian carcinoma, producing a 70% clinical response rate, but curing <20% of patients with advanced disease. We have asked whether inhibition of SIK2 with ARN-3261 enhances sensitivity to carboplatin in ovarian cancer cell lines and xenograft models. ARN-3261-induced DNA damage and apoptosis were measured with γ-H2AX accumulation, comet assays, and annexin V. ARN-3261 inhibited growth of eight ovarian cancer cell lines at an IC50 of 0.8 to 3.5 µM. ARN-3261 significantly enhanced sensitivity to carboplatin in seven of eight ovarian cancer cell lines and a carboplatin-resistant cell line tested. Furthermore, ARN-3261 in combination with carboplatin produced greater inhibition of tumor growth than carboplatin alone in SKOv3 and OVCAR8 ovarian cancer xenograft models. ARN-3261 enhanced DNA damage and apoptosis by downregulating expression of survivin. Thus, a SIK2 kinase inhibitor enhanced carboplatin-induced therapy in preclinical models of ovarian cancer and deserves further evaluation in clinical trials.

scholarly journals Reduced accumulation of platinum drugs is not observed in drug-resistant ovarian cancer cell lines derived from cisplatin-treated patients

2015 ◽  
Vol 149 ◽  
pp. 45-48 ◽  
Author(s):  
Marina Stukova ◽  
Matthew D. Hall ◽  
Samantha D. Tsotsoros ◽  
James P. Madigan ◽  
Nicholas P. Farrell ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Platinum Drugs ◽  
Drug Resistant ◽  
Ovarian Cancer Cell Lines
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