Cooperative behavior of molecular motors: Cargo transport and traffic phenomena

2010 ◽  
Vol 42 (3) ◽  
pp. 649-661 ◽  
Author(s):  
Reinhard Lipowsky ◽  
Janina Beeg ◽  
Rumiana Dimova ◽  
Stefan Klumpp ◽  
Melanie J.I. Müller
Keyword(s):  
Molecular Motors ◽  
Cooperative Behavior ◽  
Cargo Transport

scholarly journals Stochastic Modeling of Cargo Transport by Teams of Molecular Motors

2014 ◽  
pp. 609-617
Author(s):  
Sarah Klein ◽  
Cécile Appert-Rolland ◽  
Ludger Santen
Keyword(s):  
Stochastic Modeling ◽  
Molecular Motors ◽  
Cargo Transport

scholarly journals An automated in vitro motility assay for high-throughput studies of molecular motors

Lab on a Chip ◽  
2018 ◽  
Vol 18 (20) ◽  
pp. 3196-3206 ◽  
Author(s):  
Till Korten ◽  
Elena Tavkin ◽  
Lara Scharrel ◽  
Vandana Singh Kushwaha ◽  
Stefan Diez
Keyword(s):  
High Throughput ◽  
Molecular Motors ◽  
Lab On A Chip ◽  
Force Generation ◽  
Motility Assay ◽  
In Vitro Motility Assay ◽  
In Vitro Motility ◽  
Cargo Transport

Molecular motors, essential to force-generation and cargo transport within cells, are invaluable tools for powering nanobiotechnological lab-on-a-chip devices.

External forces influence the elastic coupling effects during cargo transport by molecular motors

2015 ◽  
Vol 91 (2) ◽  
Author(s):  
Florian Berger ◽  
Corina Keller ◽  
Stefan Klumpp ◽  
Reinhard Lipowsky
Keyword(s):  
Molecular Motors ◽  
Elastic Coupling ◽  
Coupling Effects ◽  
Cargo Transport ◽  
External Forces

scholarly journals COOPERATIVE TRANSPORT BY SMALL TEAMS OF MOLECULAR MOTORS

2006 ◽  
Vol 01 (04) ◽  
pp. 353-361 ◽  
Author(s):  
STEFAN KLUMPP ◽  
MELANIE J. I. MÜLLER ◽  
REINHARD LIPOWSKY
Keyword(s):  
Molecular Motors ◽  
Single Motor ◽  
Directed Transport ◽  
Cargo Transport ◽  
Cooperative Transport

Molecular motors power directed transport of cargoes within cells. Even if a single motor is sufficient to transport a cargo, motors often cooperate in small teams. We discuss the cooperative cargo transport by several motors theoretically and explore some of its properties. In particular we emphasize how motor teams can drag cargoes through a viscous environment.

scholarly journals Cargo transport: molecular motors navigate a complex cytoskeleton

2008 ◽  
Vol 20 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Jennifer L Ross ◽  
M Yusuf Ali ◽  
David M Warshaw
Keyword(s):  
Molecular Motors ◽  
Cargo Transport

scholarly journals Cargo crowding, stationary clusters and dynamical reservoirs in axonal transport

2021 ◽  
Author(s):  
Vinod Kumar ◽  
Amruta Vasudevan ◽  
Keertana Venkatesh ◽  
Reshma Maiya ◽  
Parul Sood ◽  
...  
Keyword(s):  
Axonal Transport ◽  
Molecular Motors ◽  
Experimental System ◽  
C Elegans ◽  
On Demand ◽  
Motion State ◽  
State Switching ◽  
Cargo Transport ◽  
Functional Relevance

AbstractMolecular motors drive the directed transport of presynaptic vesicles along the narrow axons of nerve cells. Stationary clusters of such vesicles are a prominent feature of axonal transport, but little is known about their physiological and functional relevance. Here, we develop a simulation model describing key features of axonal cargo transport with a view to addressing this question, benchmarking the model against our experiments in the touch neurons of C. elegans. Our simulations provide for multiple microtubule tracks and varied cargo motion states while also incorporating cargo-cargo interactions. Our model also incorporates obstacles to vesicle transport in the form of microtubule ends, stalled vesicles, and stationary mitochondria. We devise computational methodologies to simulate both axonal bleaching and axotomy, showing that our results reproduce the properties of both moving as well as stationary cargo in vivo. Increasing vesicle numbers leads to larger and more long-lived stationary clusters of vesicular cargo. Vesicle clusters are dynamically stable, explaining why they are ubiquitously seen. Modulating the rates of cargo motion-state switching allows cluster lifetimes and flux to be tuned both in simulations and experiments. We demonstrate, both in simulations and in an experimental system, that suppressing reversals leads to larger stationary vesicle clusters being formed while also reducing flux. Our simulation results support the view that the physiological significance of clusters is located in their role as dynamic reservoirs of cargo vesicles, capable of being released or sequestered on demand.

scholarly journals Cooperative cargo transport by several molecular motors

2005 ◽  
Vol 102 (48) ◽  
pp. 17284-17289 ◽  
Author(s):  
S. Klumpp ◽  
R. Lipowsky
Keyword(s):  
Molecular Motors ◽  
Cargo Transport

scholarly journals Stochastic simulations of cargo transport by processive molecular motors

2009 ◽  
Vol 131 (24) ◽  
pp. 245107 ◽  
Author(s):  
Christian B. Korn ◽  
Stefan Klumpp ◽  
Reinhard Lipowsky ◽  
Ulrich S. Schwarz
Keyword(s):  
Molecular Motors ◽  
Stochastic Simulations ◽  
Cargo Transport

scholarly journals An exact approach for studying cargo transport by an ensemble of molecular motors

2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Donatello Materassi ◽  
Subhrajit Roychowdhury ◽  
Thomas Hays ◽  
Murti Salapaka
Keyword(s):  
Molecular Motors ◽  
Exact Approach ◽  
Cargo Transport
Sign in / Sign up

Export Citation Format

Share Document