Exogenous central angiotensin fails to stimulate a sodium appetite in diabetes insipidus Brattleboro rats

2021 ◽  
Vol 230 ◽  
pp. 113308
Author(s):  
Omouessi ST ◽  
Boussera B ◽  
Ongali B ◽  
Fernette B ◽  
G.J. Lemamy ◽  
...  
Keyword(s):  
Diabetes Insipidus ◽  
Brattleboro Rats ◽  
Sodium Appetite

Antidiuretic antagonism and agonism of 1-deamino-pentamethylene-2-d-phenylalanine-4-isoleucine-arginine vasopressin in rats with diabetes insipidus

1987 ◽  
Vol 112 (3) ◽  
pp. 439-442 ◽  
Author(s):  
H. Vilhardt ◽  
S. Lundin
Keyword(s):  
Diabetes Insipidus ◽  
Arginine Vasopressin ◽  
Test Model ◽  
Brattleboro Rats ◽  
Experimental Conditions ◽  
Vasopressin Antagonist ◽  
Agonist Action

ABSTRACT Using implanted minipumps it was shown over a period of 7 days that the vasopressin antagonist, 1-deamino-pentamethylene-2-d-Phe-4-Ile-arginine vasopressin, caused increased diuresis in normal rats and reversed vasopressin- or oxytocin-induced antidiuresis in Brattleboro rats. When the antagonist was infused alone in Brattleboro rats it induced a marked antidiuretic response, indicating that the analogue also possessed agonistic properties. The agonist action could not be demonstrated in anaesthetized, hydrated normal rats. In these animals the analogue behaved as a pure antagonist. It is concluded that analogues which behave as antagonists in one test model may display agonistic properties under different experimental conditions. J. Endocr. (1987) 112, 439–442

NaCl and Ca delivery at the bend of rat deep nephrons decreases during antidiuresis

1987 ◽  
Vol 252 (6) ◽  
pp. F1055-F1064 ◽  
Author(s):  
J. M. Elalouf ◽  
D. Chabane Sari ◽  
N. Roinel ◽  
C. de Rouffignac
Keyword(s):  
Parathyroid Hormone ◽  
Diabetes Insipidus ◽  
Arginine Vasopressin ◽  
Distal Tubule ◽  
Water Removal ◽  
Loop Of Henle ◽  
Brattleboro Rats ◽  
Previous Hypothesis

The effects of 1-desamino-8-D-arginine vasopressin (dDAVP) on superficial and juxtamedullary nephrons were investigated by micropuncture in diabetes insipidus (DI) Brattleboro rats chronically treated with the peptide. The rats, acutely deprived of endogenous calcitonin, parathyroid hormone (PTH), and glucagon [hormone-deprived (HD) rats], were examined either 4 days after cessation of dDAVP treatment (HDT, control diuretic rats) or when the treatment was continued until the micropuncture experiment, during which dDAVP was also given intravenously (HDT + dDAVP, experimental nondiuretic rats). In the presence of dDAVP, the reabsorption of Cl, Na, Mg, and Ca by the superficial loop of Henle was significantly increased, as previously observed in HD-untreated rats during acute infusion of dDAVP. The effects on the superficial distal tubule were also similar. The effects on K, however, were different both in the loop and in the distal tubule. At the bend of the juxtamedullary nephrons, the treatment alone (HDT rats) increased fractional delivery (FD%) of Na and Cl, whereas FD% of Mg, Ca, K, and P was unaltered. In HDT + dDAVP rats, FD% of H2O, Cl, Na, and Ca was significantly lower than in HDT rats, and FD% of K, Mg, and P did not differ significantly. In conclusion, in the presence of dDAVP, the FD% of H2O, Na, and Cl at the bend of the long-loop nephrons decreases, in accordance with our previous hypothesis that water removal along the rat descending limb increases outward NaCl diffusion along this segment.

High, vasopressin-reversible, immunoreactive somatostatin in specific hypothalamic nuclei of rats with diabetes insipidus (Brattleboro rats)

1983 ◽  
Vol 277 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Juan M. Saavedra ◽  
Catherine Rougeot ◽  
Claude Chevillard ◽  
Fernand Dray
Keyword(s):  
Diabetes Insipidus ◽  
Brattleboro Rats ◽  
Hypothalamic Nuclei

Atrial Natriuretic Peptides in Brain Nuclei of Rats with Inherited Diabetes insipidus (Brattleboro Rats)

1990 ◽  
Vol 51 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Udo Bahner ◽  
Helmut Geiger ◽  
Miklos Palkovits ◽  
Detlev Ganten ◽  
Joachim Michel ◽  
...  
Keyword(s):  
Diabetes Insipidus ◽  
Natriuretic Peptides ◽  
Brattleboro Rats ◽  
Atrial Natriuretic Peptides ◽  
Brain Nuclei ◽  
Inherited Diabetes ◽  
Atrial Natriuretic

Enhanced noradrenergic activity in kidney of Brattleboro rats with diabetes insipidus

1986 ◽  
Vol 250 (4) ◽  
pp. R567-R572
Author(s):  
R. L. Kline ◽  
K. P. Patel ◽  
P. F. Mercer
Keyword(s):  
Skeletal Muscle ◽  
Diabetes Insipidus ◽  
Adrenal Glands ◽  
Brattleboro Rats ◽  
Sympathetic Nervous System Activity ◽  
Peripheral Organs ◽  
Nervous System Activity ◽  
Sympathetic Nervous ◽  
Long Evans ◽  
Selective Increase

The possibility that sympathetic nervous system activity may be altered in Brattleboro rats with diabetes insipidus (DI) was studied using the norepinephrine (NE) turnover technique. Female DI and Long-Evans rats were used. NE turnover in peripheral organs was calculated by measuring the decline in tissue [NE] after inhibition of tyrosine hydroxylase with alpha-methyltyrosine. NE turnover was increased significantly in the kidney of DI rats but was not significantly altered in other peripheral organs examined (heart, duodenum, skeletal muscle). Both NE and epinephrine concentrations in the adrenal gland were significantly higher in the DI rats. Treatment of DI rats for 7 days with vasopressin tannate (Pitressin, 100 mU/100 g) or 1-deamino-[8-D-arginine] vasopressin (DDAVP, 250 ng X kg-1 X day-1) reversed the changes in renal NE turnover and also decreased the turnover in other tissues. The results of these studies suggest that, compared with Long-Evans rats, DI rats have a selective increase in NE turnover in the kidney and the potential to release more catecholamines from the adrenal glands. The apparently nonspecific effect of antidiuretic therapy on NE turnover in DI rats is probably mediated by the epithelial receptor for vasopressin, because both Pitressin and DDAVP produced similar results.

Impaired Response to Vasopressin of Adenylate Cyclase of the Thick Ascending Limb of Henle’s Loop in Brattleboro Rats with Diabetes insipidus

1978 ◽  
Vol 1 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Martine Imbert-Teboul ◽  
Danielle Chabardès ◽  
Madeleine Montégut ◽  
André Clique ◽  
François Morel
Keyword(s):  
Adenylate Cyclase ◽  
Diabetes Insipidus ◽  
Thick Ascending Limb ◽  
Brattleboro Rats
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